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PAK1 and CDK11B
Number of citations of the paper that reports this interaction (PMID
12624090
)
6
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
PAK1
CDK11B
Gene Name
p21 protein (Cdc42/Rac)-activated kinase 1
cyclin-dependent kinase 11B
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Ruffle
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Intercalated Disc
Z Disc
Axon
Dendrite
Growth Cone
Filamentous Actin
Nuclear Membrane
Ruffle Membrane
Protein Complex
Nucleus
Cytoplasm
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Receptor Signaling Protein Serine/threonine Kinase Activity
Protein Binding
Collagen Binding
ATP Binding
Protein Kinase Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Poly(A) RNA Binding
Biological Process
MAPK Cascade
Mitotic Cell Cycle
Response To Hypoxia
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Exocytosis
Apoptotic Process
Axon Guidance
Neuromuscular Junction Development
Dendrite Development
Signal Transduction By Phosphorylation
T Cell Costimulation
Actin Cytoskeleton Reorganization
Cellular Response To Insulin Stimulus
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Wound Healing
Receptor Clustering
Positive Regulation Of JUN Kinase Activity
Innate Immune Response
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Branching Morphogenesis Of An Epithelial Tube
Neuron Projection Morphogenesis
T Cell Receptor Signaling Pathway
Positive Regulation Of Stress Fiber Assembly
Negative Regulation Of Cell Proliferation Involved In Contact Inhibition
Regulation Of Cell Growth
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Apoptotic Process
Mitotic Nuclear Division
Cell Proliferation
Regulation Of MRNA Processing
Regulation Of Cell Cycle
Pathways
Axon guidance
Costimulation by the CD28 family
FCERI mediated MAPK activation
L1CAM interactions
VEGFA-VEGFR2 Pathway
EPHB-mediated forward signaling
Ephrin signaling
Activation of Rac
VEGFR2 mediated vascular permeability
EPH-Ephrin signaling
Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation
Innate Immune System
Generation of second messenger molecules
Signal transduction by L1
Semaphorin interactions
CD28 co-stimulation
CD28 dependent Vav1 pathway
TCR signaling
DSCAM interactions
Signaling by VEGF
Sema3A PAK dependent Axon repulsion
Fc epsilon receptor (FCERI) signaling
Signaling by Robo receptor
Adaptive Immune System
G2/M Transition
Centrosome maturation
Mitotic G2-G2/M phases
Cell Cycle, Mitotic
Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS
Protein-Protein Interactions
83 interactors:
ABI3
ACTA1
ACVR1
AKT1
APP
ARHGEF2
ARHGEF6
ARHGEF7
ARPC1B
BAD
BAIAP2
BMPR1B
BMX
BRSK1
C5orf42
CASP1
CDC42
CDK11B
CDK5
CDK5R1
CHORDC1
COL1A1
CRIPAK
CSNK2A1
CSNK2A2
DSCAM
DYNLL1
DYNLL2
DYRK1B
EGFR
ELF3
ERBB2
ESR1
FLNA
FOXL2
FOXO1
FRS2
GIT2
GRB2
HGS
HIST1H3A
HIST1H4A
HSP90AA1
LIMK1
MAP2K1
MAP3K1
MAPK1
MBP
MYLK
MYNN
MYO6
NCK1
NCK2
NF2
OXSR1
PAK1IP1
PDPK1
PLCG1
PPM1F
PRKCD
PXN
RAC1
RAF1
RHOJ
RHOU
SHC1
SMAD1
SMAD2
SMAD4
SMURF1
SORBS2
SORBS3
SYN1
TGFBR1
TGFBR2
TGM2
YWHAG
YWHAZ
ZBTB18
ZC3H7A
ZNF418
ZNF823
ZNF83
22 interactors:
AP2M1
CASP1
CASP3
CASP8
CCND3
CCNL2
EIF3F
KAT7
MSN
PAK1
PIN1
RANBP9
RPS27A
TCEA2
TH
TPPP
URM1
YWHAB
YWHAE
YWHAG
YWHAQ
YWHAZ
Entrez ID
5058
984
HPRD ID
03995
08909
Ensembl ID
ENSG00000149269
ENSG00000248333
Uniprot IDs
B3KNX7
Q13153
P21127
PDB IDs
1F3M
1YHV
1YHW
1ZSG
2HY8
2QME
3DVP
3FXZ
3FY0
3Q4Z
3Q52
3Q53
4DAW
4EQC
Enriched GO Terms of Interacting Partners
?
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Signaling
Regulation Of Signal Transduction
Anatomical Structure Morphogenesis
Regulation Of Cellular Component Organization
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of Phosphorylation
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Cell Differentiation
Cell Development
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Fc Receptor Signaling Pathway
Cell Morphogenesis Involved In Differentiation
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Signal Transduction
Anatomical Structure Development
System Development
Regulation Of Kinase Activity
Intracellular Signal Transduction
Developmental Process
Regulation Of Protein Phosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Cellular Process
Regulation Of Organelle Organization
Neurotrophin Signaling Pathway
Regulation Of Protein Kinase Activity
Multicellular Organismal Development
Neurogenesis
Axon Guidance
Regulation Of Protein Metabolic Process
Cell Morphogenesis Involved In Neuron Differentiation
Generation Of Neurons
Axonogenesis
Cell Communication
Cell Projection Organization
Tissue Development
Cell Morphogenesis
Positive Regulation Of Cellular Metabolic Process
Regulation Of Intracellular Signal Transduction
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Signaling
Neuron Projection Morphogenesis
Axon Development
Regulation Of Metabolic Process
Positive Regulation Of Protein Metabolic Process
Defense Response
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrion Organization
Regulation Of Mitochondrion Organization
Intrinsic Apoptotic Signaling Pathway
Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Organelle Organization
Protein Targeting
Positive Regulation Of Intracellular Transport
Regulation Of Protein Metabolic Process
Cellular Response To Organic Substance
Regulation Of Cellular Component Organization
Regulation Of Protein Localization
Membrane Organization
Intracellular Protein Transport
Positive Regulation Of Signal Transduction
Regulation Of Organelle Organization
Immune System Process
Neurotrophin TRK Receptor Signaling Pathway
Cellular Protein Localization
Neurotrophin Signaling Pathway
Regulation Of Establishment Of Protein Localization
Regulation Of Intracellular Transport
Regulation Of Cellular Localization
Regulation Of Catalytic Activity
Hippo Signaling
Regulation Of Apoptotic Process
Regulation Of Protein Phosphorylation
Regulation Of Protein Kinase Activity
Positive Regulation Of Transport
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Establishment Of Localization In Cell
Response To Organic Substance
Regulation Of Cell Death
Regulation Of Kinase Activity
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Regulation Of Signal Transduction
Cellular Response To Growth Factor Stimulus
Tagcloud
?
advance
belonging
cdc2
cdc42
coordinate
coordinates
coordinating
cot1
delays
dystrophy
encodes
fission
genetically
interphase
maintain
maintains
mitosis
mitotic
morphogenesis
myotonic
orb2
orb6
p34
polarity
polarized
ras1
shape
shk1
threonine
Tagcloud (Difference)
?
advance
belonging
cdc2
cdc42
coordinate
coordinates
coordinating
cot1
delays
dystrophy
encodes
fission
genetically
interphase
maintain
maintains
mitosis
mitotic
morphogenesis
myotonic
orb2
orb6
p34
polarity
polarized
ras1
shape
shk1
threonine
Tagcloud (Intersection)
?