PAK1 and MBP

Number of citations of the paper that reports this interaction (PubMedID 14579272)
0

Data Source:
HPRD (in vitro)

		PAK1	MBP
Description		p21 (RAC1) activated kinase 1	myelin basic protein
Image
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Intercalated Disc Membrane Z Disc Lamellipodium Axon Dendrite Nuclear Membrane Ruffle Membrane Protein-containing Complex Cell Projection Anchoring Junction	Nucleus Cytosol Plasma Membrane Cell Surface Membrane Protein-containing Complex Internode Region Of Axon Cell Projection Neuronal Cell Body Myelin Sheath Compact Myelin Synapse Cell Periphery
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Collagen Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Small GTPase Binding Identical Protein Binding Gamma-tubulin Binding Protein Serine Kinase Activity	Protease Binding Protein Binding Calmodulin Binding Lipid Binding Structural Constituent Of Myelin Sheath
	Biological Process	MAPK Cascade Response To Hypoxia Stimulatory C-type Lectin Receptor Signaling Pathway Chromatin Remodeling Exocytosis Apoptotic Process DNA Damage Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Fibroblast Migration Cell Migration Cerebellum Development Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Microtubule Polymerization Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Wound Healing Regulation Of MAPK Cascade Positive Regulation Of Axon Extension Positive Regulation Of Insulin Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Microtubule Nucleation Positive Regulation Of Protein Targeting To Membrane Regulation Of Actin Filament Organization Protein Localization To Cytoplasmic Stress Granule Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	MAPK Cascade Immune Response Chemical Synaptic Transmission Central Nervous System Development Sensory Perception Of Sound Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Positive Regulation Of Interleukin-6 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Maintenance Of Blood-brain Barrier Myelination Membrane Organization Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation FCERI mediated MAPK activation FCERI mediated MAPK activation CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 Signal transduction by L1 Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PKNs RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		Fostamatinib
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245) Tourette syndrome ( 30818990)	Age-related macular degeneration (geographic atrophy) ( 22705344) Blood osmolality (transformed sodium) ( 28360221) Depression in smokers ( 30219690) Erythrocyte cadmium concentration in never smokers ( 27005419) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Verbal declarative memory ( 25648963)
Interacting Genes		89 interacting genes: ABI3 ACTA1 ACVR1 AKT1 APP ARHGEF2 ARHGEF6 ARHGEF7 ARPC1B BAD BAIAP2 BCL6 BMPR1B BMX BRSK1 BTG3 CASP1 CDC42 CDK11B CDK5 CDK5R1 CHORDC1 COL1A1 CPLANE1 CSNK2A1 CSNK2A2 DSCAM DSCR9 DYNLL1 DYNLL2 DYRK1B EGFR ELF3 ERBB2 ESR1 FLNA FOXL2 FOXO1 FRS2 GIT2 GRB2 H3C1 H4C1 HACE1 HGS HSP90AA1 KEAP1 LIMK1 MAP2K1 MAP3K1 MAPK1 MBP MYLK MYNN MYO6 NCK1 NCK2 NF2 OXSR1 PAK1IP1 PDPK1 PLCG1 PPM1A PPM1F PPP1CA PPP2CA PRKCD PXN RAC1 RAF1 RHOJ RHOU SHC1 SMAD1 SMAD2 SMAD4 SMURF1 SORBS2 SYN1 TGFBR1 TGFBR2 TGM2 YWHAG YWHAZ ZBTB18 ZC3H7A ZNF418 ZNF823 ZNF83	83 interacting genes: ABL1 ADRB2 APTX ATN1 ATXN1 AURKA BMP2K CCR1 CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 CTDSPL DYRK1B HIPK2 HLA-DRA IKBKE ILK IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP2K1 MAP3K1 MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPK8 MAPKAPK5 MELK MICU2 MKNK1 MMP7 NEIL3 NEK9 PAK1 PDGFRL PKN1 PLEKHF2 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 PTAFR PTPRA RAF1 RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSC1 TSSK6 ULK1
Entrez ID		5058	4155
HPRD ID		03995	01158
Ensembl ID		ENSG00000149269	ENSG00000197971
Uniprot IDs		B3KNX7 E9PM17 Q13153	P02686
PDB IDs		1F3M 1YHV 1YHW 1ZSG 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC 4O0R 4O0T 4P90 4ZJI 4ZJJ 4ZLO 4ZY4 4ZY5 4ZY6 5DEW 5DEY 5DFP 5IME 5KBQ 5KBR 6B16 7VTO 8X5Z	1BX2 1FV1 1HQR 1K2D 1YMM 1ZGL
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Protein Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Signal Transduction Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of Developmental Process Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Multicellular Organismal Process Response To Growth Factor Regulation Of Signal Transduction Anatomical Structure Morphogenesis Regulation Of Supramolecular Fiber Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Protein Phosphorylation ERBB Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Locomotion Focal Adhesion Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Lamellipodium Phosphorylation Regulation Of Anatomical Structure Morphogenesis Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Motility Protein Kinase Binding Regulation Of Locomotion Cytosol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cellular Component Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Cell Migration Developmental Process Regulation Of Cytoskeleton Organization Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Protein Localization	Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Kinase Activity Kinase Activity Protein Phosphorylation ATP Binding Phosphorylation Transferase Activity Nucleotide Binding Intracellular Signal Transduction Protein Modification Process Phosphate-containing Compound Metabolic Process MAPK Cascade Protein Metabolic Process Response To Stress Intracellular Signaling Cassette Cellular Response To Stress Peptidyl-serine Phosphorylation Macromolecule Metabolic Process Protein Autophosphorylation Signal Transduction MAP Kinase Activity Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Positive Regulation Of Biosynthetic Process Regulation Of Developmental Process Regulation Of MAPK Cascade Nucleus Positive Regulation Of Developmental Process Magnesium Ion Binding Positive Regulation Of Intracellular Signal Transduction DNA Damage Response RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Development Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Peptidyl-threonine Phosphorylation Nucleoplasm Stress-activated MAPK Cascade Regulation Of Gene Expression Stress-activated Protein Kinase Signaling Cascade Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Cell Surface Receptor Signaling Pathway
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