PLCG1 and LCK

Number of citations of the paper that reports this interaction (PubMedID 1500851)
30

Data Source:
HPRD (in vivo)

		PLCG1	LCK
Description		phospholipase C gamma 1	LCK proto-oncogene, Src family tyrosine kinase
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane COP9 Signalosome Lamellipodium Ruffle Membrane Cell Projection	Pericentriolar Material Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Guanyl-nucleotide Exchange Factor Activity Neurotrophin TRKA Receptor Binding Calcium Ion Binding Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Protein Kinase Binding Metal Ion Binding Calcium-dependent Phospholipase C Activity Phosphatidylinositol Phospholipase C Activity	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Serine/threonine Phosphatase Activity Signaling Receptor Binding Protein Binding ATP Binding Phospholipase Activator Activity Kinase Activity Transferase Activity Protein Kinase Binding Protein Phosphatase Binding SH2 Domain Binding T Cell Receptor Binding CD4 Receptor Binding CD8 Receptor Binding Identical Protein Binding Phospholipase Binding Phosphatidylinositol 3-kinase Binding ATPase Binding Protein Antigen Binding
	Biological Process	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Phospholipid Catabolic Process Positive Regulation Of Epithelial Cell Migration Lipid Catabolic Process Cell Migration Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Sequestering Of Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process	Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Phosphorylation Intracellular Zinc Ion Homeostasis Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Hemopoiesis Platelet Activation T Cell Differentiation T Cell Costimulation Positive Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway T Cell Activation Gamma-delta T Cell Differentiation Positive Regulation Of MAPK Cascade Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of Regulatory T Cell Differentiation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Leukocyte Migration Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Multicellular Organismal Process Regulation Of Lymphocyte Activation CD27 Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		ISG15 antiviral mechanism Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PLCG1 events in ERBB2 signaling DAG and IP3 signaling PLC-gamma1 signalling Synthesis of IP3 and IP4 in the cytosol Downstream signal transduction Signaling by ALK Generation of second messenger molecules Role of phospholipids in phagocytosis Role of phospholipids in phagocytosis PECAM1 interactions EGFR interacts with phospholipase C-gamma DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Role of second messengers in netrin-1 signaling VEGFR2 mediated cell proliferation VEGFR2 mediated cell proliferation Constitutive Signaling by EGFRvIII Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RET signaling Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Erythropoietin activates Phospholipase C gamma (PLCG) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 FCGR3A-mediated IL10 synthesis Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by ALK fusions and activated point mutants	GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Nef and signal transduction Nef Mediated CD4 Down-regulation Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PECAM1 interactions Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling DAP12 signaling Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway Co-inhibition by CTLA4 Co-inhibition by PD-1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOH GTPase cycle Interleukin-2 signaling Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants FLT3 signaling through SRC family kinases
Drugs			Dasatinib AP-22408 Staurosporine 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine {4-[(2S)-2-Acetamido-3-({(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl}amino)-3-oxopropyl]-2-phosphonophenoxy}acetic acid Phosphoaminophosphonic Acid-Adenylate Ester 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine Ponatinib Nintedanib Fostamatinib Zanubrutinib Zotiraciclib
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Apolipoprotein B levels ( 32203549) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) LDL cholesterol levels ( 32203549) Major depressive disorder ( 27479909) Male-pattern baldness ( 28196072) Refractive error ( 32231278) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Multiple sclerosis ( 31604244)
Interacting Genes		112 interacting genes: ABL1 AGAP2 AGTR1 AKT1 ALK AR ARHGAP32 ARHGEF5 AXL BAG3 BCR BLNK BTK CBL CD22 CD28 CTSS DAB1 DAPP1 DDR1 DGKZ DNM1 DOK1 EEF1A1 EGFR EPHB2 EPOR ERBB2 ERBB3 ERBB4 FGFR1 FGFR2 FGFR4 FLT1 FYN GAB1 GAB2 GHR GIT1 GRAP GRB2 GRIN1 GRIN2A GRIN2B GSN GTF2H1 HCK INPP5D INSR IRS2 ITK KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LIFR LYN MAPT MET MST1R NCAM1 NCK1 NPM1 NTRK1 NTRK2 NTRK3 PAK1 PDGFRA PDGFRB PECAM1 PICALM PITPNA PKN2 PLD2 PRKD1 PRMT8 PTK2 PTPN11 PTPRJ RACK1 RBM11 RET RHOA RHOU SELE SH2D2A SH3BP2 SHB SHC1 SNAP91 SOCS7 SOS1 SOS2 SRC SYK SYN1 SYNCRIP TEC TNK1 TRIM14 TRPC3 TRPM7 TUB USO1 VAV1 VAV3 VIL1 WAS ZAP70	142 interacting genes: ACP1 ADAM15 AJUBA AR ARHGAP17 ASB9 AXL BCAR1 BRCA1 C1QTNF2 CBL CCR5 CD2 CD247 CD28 CD38 CD3E CD4 CD44 CD48 CD5 CD55 CD79A CD79B CD8A CDC25C CDC42 CDC45 CDKAL1 CIMIP2B CSF2RB CSF3R CSK CSNK2B CTDSP1 CTLA4 CTNND2 DAPP1 DEF6 DLG1 DOK1 DOK2 DOK3 EGFR ERBB2 ERBB3 ERBB4 ESR1 ESR2 EZR FAM174A FAS FASLG FCGR3A FYN G3BP1 GAB2 GATA3 GRAP HSP90AA1 IFNAR1 IKBKG IL2RB ITK JAK3 KHDRBS1 KIR2DL3 KIT LAT LAX1 LCP2 LIME1 LZTS2 MAPK1 MAPK3 MAPT MED28 MET MS4A1 MUC1 NEDD9 NFKBIA NFKBID NOTCH1 NR3C1 PAG1 PAK2 PECAM1 PI4KA PIK3CA PIK3R1 PLCG1 PLCG2 PLD2 PRKACA PRKCA PRKCD PRKCQ PTK2 PTK2B PTPN11 PTPN22 PTPN6 PTPRC PTPRF PTPRH PXN RAF1 RASA1 RIN3 RORB SH2B3 SH2D1A SH2D2A SH3BP2 SHC1 SIT1 SKAP1 SKAP2 SMAD2 SMAD3 SMURF1 SOCS1 SOS1 SQSTM1 STAT1 STAT3 STAT5A SYK THY1 TRAT1 TRIM35 TRPV4 TUB UBAP2 UBE3A UHRF2 UNC119 VAV1 WAS WASL ZAP70
Entrez ID		5335	3932
HPRD ID		01398	01080
Ensembl ID		ENSG00000124181	ENSG00000182866
Uniprot IDs		P19174	A0A0S2Z3Y8 E9PJ92 E9PKQ8 P06239 Q573B4
PDB IDs		1HSQ 2HSP 4EY0 4FBN 7NXE	1BHF 1BHH 1CWD 1CWE 1FBZ 1H92 1IJR 1KIK 1LCJ 1LCK 1LKK 1LKL 1Q68 1Q69 1QPC 1QPD 1QPE 1QPJ 1X27 2IIM 2OF2 2OF4 2OFU 2OFV 2OG8 2PL0 2ZM1 2ZM4 2ZYB 3AC1 3AC2 3AC3 3AC4 3AC5 3AC8 3ACJ 3ACK 3AD4 3AD5 3AD6 3B2W 3BRH 3BYM 3BYO 3BYS 3BYU 3KMM 3KXZ 3LCK 3MPM 4C3F 4D8K 5MTM 5MTN 6H6A 6PDJ 8X2P
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Plasma Membrane Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Phosphorylation Phosphorylation Regulation Of Signal Transduction Protein Autophosphorylation Positive Regulation Of Signal Transduction Cell Migration Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Immune Response-activating Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Receptor Complex Antigen Receptor-mediated Signaling Pathway Cell Motility Activation Of Immune Response Immune System Process Intracellular Signaling Cassette Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Population Proliferation Fc Receptor Signaling Pathway ATP Binding Cell Activation Positive Regulation Of Cellular Component Organization Regulation Of Cell Population Proliferation Response To Growth Factor Developmental Process Nucleotide Binding Leukocyte Activation Regulation Of Immune Response Positive Regulation Of Immune System Process	Signal Transduction Cell Surface Receptor Signaling Pathway Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Immune Response-activating Signaling Pathway Activation Of Immune Response Plasma Membrane Intracellular Signal Transduction T Cell Receptor Signaling Pathway Lymphocyte Activation Positive Regulation Of Immune Response Leukocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Adhesion Immune Response Adaptive Immune Response Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Intracellular Signaling Cassette Regulation Of Cell Activation Protein Kinase Binding Regulation Of T Cell Activation T Cell Activation Cytokine-mediated Signaling Pathway Regulation Of MAPK Cascade Regulation Of Leukocyte Cell-cell Adhesion B Cell Receptor Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Phosphotyrosine Residue Binding Regulation Of Cellular Component Organization Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction ERBB Signaling Pathway
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