PLCG1 and NTRK1

Number of citations of the paper that reports this interaction (PubMedID 35384245)
105

Data Source:
BioGRID (pull down, affinity chromatography technology, proximity labelling technology)
HPRD (in vivo)

		PLCG1	NTRK1
Description		phospholipase C gamma 1	neurotrophic receptor tyrosine kinase 1
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane COP9 Signalosome Lamellipodium Ruffle Membrane Cell Projection	Cytoplasm Mitochondrion Endosome Early Endosome Late Endosome Plasma Membrane Cell Surface Endosome Membrane Membrane Axon Dendrite Early Endosome Membrane Late Endosome Membrane Protein-containing Complex Neuronal Cell Body Receptor Complex Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Guanyl-nucleotide Exchange Factor Activity Neurotrophin TRKA Receptor Binding Calcium Ion Binding Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Protein Kinase Binding Metal Ion Binding Calcium-dependent Phospholipase C Activity Phosphatidylinositol Phospholipase C Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Neurotrophin Receptor Activity Neurotrophin P75 Receptor Binding Protein Binding ATP Binding Nerve Growth Factor Receptor Activity Kinase Activity Transferase Activity Kinase Binding Identical Protein Binding Protein Homodimerization Activity Neurotrophin Binding Nerve Growth Factor Binding
	Biological Process	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Phospholipid Catabolic Process Positive Regulation Of Epithelial Cell Migration Lipid Catabolic Process Cell Migration Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Sequestering Of Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process	Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Spermatogenesis Nervous System Development Axon Guidance Learning Or Memory Circadian Rhythm Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Programmed Cell Death Involved In Cell Development Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Olfactory Nerve Development Cell Differentiation B Cell Differentiation Neuron Projection Development Response To Nutrient Levels Response To Nicotine Peptidyl-tyrosine Autophosphorylation Nerve Growth Factor Signaling Pathway Mechanoreceptor Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Positive Regulation Of Ras Protein Signal Transduction Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Sympathetic Nervous System Development Neuron Development Response To Axon Injury Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of NF-kappaB Transcription Factor Activity Neuron Apoptotic Process Response To Hydrostatic Pressure Response To Electrical Stimulus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Sertoli Cell Development Innervation Axonogenesis Involved In Innervation Behavioral Response To Formalin Induced Pain Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Nicotine Cellular Response To Growth Factor Stimulus Cellular Response To Amyloid-beta Cellular Response To Nerve Growth Factor Stimulus
Pathways		ISG15 antiviral mechanism Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PLCG1 events in ERBB2 signaling DAG and IP3 signaling PLC-gamma1 signalling Synthesis of IP3 and IP4 in the cytosol Downstream signal transduction Signaling by ALK Generation of second messenger molecules Role of phospholipids in phagocytosis Role of phospholipids in phagocytosis PECAM1 interactions EGFR interacts with phospholipase C-gamma DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Role of second messengers in netrin-1 signaling VEGFR2 mediated cell proliferation VEGFR2 mediated cell proliferation Constitutive Signaling by EGFRvIII Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RET signaling Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Erythropoietin activates Phospholipase C gamma (PLCG) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 FCGR3A-mediated IL10 synthesis Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by ALK fusions and activated point mutants	PLC-gamma1 signalling Signalling to RAS ARMS-mediated activation ARMS-mediated activation Retrograde neurotrophin signalling Retrograde neurotrophin signalling NGF-independant TRKA activation TRKA activation by NGF TRKA activation by NGF Signalling to p38 via RIT and RIN PI3K/AKT activation PI3K/AKT activation Signalling to STAT3
Drugs			Amitriptyline Imatinib Regorafenib Entrectinib Fostamatinib Cenegermin Larotrectinib Pralsetinib
Diseases			Neuroblastoma Thyroid cancer
GWAS		Apolipoprotein B levels ( 32203549) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) LDL cholesterol levels ( 32203549) Major depressive disorder ( 27479909) Male-pattern baldness ( 28196072) Refractive error ( 32231278) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Red cell distribution width ( 32888494)
Interacting Genes		112 interacting genes: ABL1 AGAP2 AGTR1 AKT1 ALK AR ARHGAP32 ARHGEF5 AXL BAG3 BCR BLNK BTK CBL CD22 CD28 CTSS DAB1 DAPP1 DDR1 DGKZ DNM1 DOK1 EEF1A1 EGFR EPHB2 EPOR ERBB2 ERBB3 ERBB4 FGFR1 FGFR2 FGFR4 FLT1 FYN GAB1 GAB2 GHR GIT1 GRAP GRB2 GRIN1 GRIN2A GRIN2B GSN GTF2H1 HCK INPP5D INSR IRS2 ITK KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LIFR LYN MAPT MET MST1R NCAM1 NCK1 NPM1 NTRK1 NTRK2 NTRK3 PAK1 PDGFRA PDGFRB PECAM1 PICALM PITPNA PKN2 PLD2 PRKD1 PRMT8 PTK2 PTPN11 PTPRJ RACK1 RBM11 RET RHOA RHOU SELE SH2D2A SH3BP2 SHB SHC1 SNAP91 SOCS7 SOS1 SOS2 SRC SYK SYN1 SYNCRIP TEC TNK1 TRIM14 TRPC3 TRPM7 TUB USO1 VAV1 VAV3 VIL1 WAS ZAP70	41 interacting genes: ABL1 ARHGAP32 CAV1 CRK DNAJA3 DYNLL1 ERBB2 FRS2 FRS3 GIPC1 GRB2 HIPK2 IRS1 IRS2 KIDINS220 MAPK3 MATK NEDD4L NGF NGFR NTF3 PIK3R1 PLCG1 PTPN1 PTPN11 PTPRR RAP1A RASA1 RASGRF1 RUSC1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SORT1 SQSTM1 TPTE TRAF4 TRAF6 UBB
Entrez ID		5335	4914
HPRD ID		01398	01869
Ensembl ID		ENSG00000124181	ENSG00000198400
Uniprot IDs		P19174	P04629 X5DR71
PDB IDs		1HSQ 2HSP 4EY0 4FBN 7NXE	1HE7 1SHC 1WWA 1WWW 2IFG 2N90 4AOJ 4CRP 4F0I 4GT5 4PMM 4PMP 4PMS 4PMT 4YNE 4YPS 5H3Q 5I8A 5JFS 5JFV 5JFW 5JFX 5KMI 5KMJ 5KMK 5KML 5KMM 5KMN 5KMO 5KVT 5WR7 6D1Y 6D1Z 6D20 6D22 6DKB 6DKG 6DKI 6DKW 6IQN 6J5L 6NPT 6NSP 6NSS 6PL1 6PL2 6PL3 6PL4 6PMA 6PMB 6PMC 6PME 7N3T 7VKM 7VKN 7VKO 7XAF 7XBI 8J5W 8J5X 8J61 8J63 8YTD 8YTE
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Plasma Membrane Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Phosphorylation Phosphorylation Regulation Of Signal Transduction Protein Autophosphorylation Positive Regulation Of Signal Transduction Cell Migration Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Immune Response-activating Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Receptor Complex Antigen Receptor-mediated Signaling Pathway Cell Motility Activation Of Immune Response Immune System Process Intracellular Signaling Cassette Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Population Proliferation Fc Receptor Signaling Pathway ATP Binding Cell Activation Positive Regulation Of Cellular Component Organization Regulation Of Cell Population Proliferation Response To Growth Factor Developmental Process Nucleotide Binding Leukocyte Activation Regulation Of Immune Response Positive Regulation Of Immune System Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Phosphotyrosine Residue Binding Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cytosol Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Regulation Of Signal Transduction ERBB Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Neurotrophin TRKA Receptor Binding Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Insulin Receptor Binding Neurotrophin Signaling Pathway Plasma Membrane Regulation Of Apoptotic Process Nerve Growth Factor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Response To Growth Factor Regulation Of Programmed Cell Death Intracellular Signaling Cassette Signaling Adaptor Activity Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Population Proliferation Ephrin Receptor Binding Protein Kinase Binding Positive Regulation Of Cell Population Proliferation Regulation Of Immune Response Positive Regulation Of D-glucose Import Regulation Of Cell Adhesion Enzyme Binding Regulation Of Cellular Localization SH2 Domain Binding Insulin-like Growth Factor Receptor Binding Developmental Process Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Biological Quality Negative Regulation Of Programmed Cell Death
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