PAK1 and RAC1

  • Number of citations of the paper that reports this interaction (PMID 8107774)
  • 323
  • Data Source:
  • BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
  • HPRD (in vitro, in vivo)

PAK1

RAC1

Gene Name p21 protein (Cdc42/Rac)-activated kinase 1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 83 interactors: ABI3 ACTA1 ACVR1 AKT1 APP ARHGEF2 ARHGEF6 ARHGEF7 ARPC1B BAD BAIAP2 BMPR1B BMX BRSK1 C5orf42 CASP1 CDC42 CDK11B CDK5 CDK5R1 CHORDC1 COL1A1 CRIPAK CSNK2A1 CSNK2A2 DSCAM DYNLL1 DYNLL2 DYRK1B EGFR ELF3 ERBB2 ESR1 FLNA FOXL2 FOXO1 FRS2 GIT2 GRB2 HGS HIST1H3A HIST1H4A HSP90AA1 LIMK1 MAP2K1 MAP3K1 MAPK1 MBP MYLK MYNN MYO6 NCK1 NCK2 NF2 OXSR1 PAK1IP1 PDPK1 PLCG1 PPM1F PRKCD PXN RAC1 RAF1 RHOJ RHOU SHC1 SMAD1 SMAD2 SMAD4 SMURF1 SORBS2 SORBS3 SYN1 TGFBR1 TGFBR2 TGM2 YWHAG YWHAZ ZBTB18 ZC3H7A ZNF418 ZNF823 ZNF83 144 interactors: ACTA1 ACTB AKT1 ARFIP2 ARHGAP1 ARHGAP15 ARHGAP17 ARHGAP27 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP44 ARHGDIA ARHGDIB ARHGDIG ARHGEF2 ARHGEF25 ARHGEF4 ARHGEF7 ARL2BP BAG6 BAIAP2 BCR BIRC2 BRINP1 CASP3 CASP7 CAV1 CDC23 CDC42 CDC42BPG CDC42SE1 CDC42SE2 CFAP36 CHN1 CHN2 CIT CNTNAP1 COG5 COX3 CSN2 CYBA CYBB CYFIP1 DEF6 DIAPH1 DIAPH3 DMPK DOCK1 DOCK2 DOCK8 DVL1 DVL2 EIF2AK2 FHOD1 FLNA FMNL1 GRN HACD3 HPS4 ICMT IFNGR1 IL1RAP IQGAP1 IQGAP2 KALRN KPNA4 KPNA6 KRT40 KTN1 LATS1 LTBP3 LTBP4 LZTS2 MAGI1 MAP3K10 MAP3K11 MAP3K4 MCF2L MCM3AP METAP2 MTNR1A MYD88 MYH9 NCF2 NCK1 NCKAP1 NEDD4 NME1 NOS2 NOXA1 OCRL OPHN1 PAK1 PAK2 PAK3 PAK7 PARD6A PARD6B PARD6G PARK2 PIAS3 PIK3R1 PIP4K2A PLD1 PLEKHG2 PLXNB1 PPP2R2B PRKCA PRKCD PRKCI PRMT6 PTK2 RALBP1 RAP1GDS1 RASGRF1 RCC2 RGL2 RPS6KB1 SET SFPQ SH3BP1 SH3RF1 SH3RF3 STAT1 STAT3 STAU1 SUMO2 SYNJ2 TBC1D3F TIAM1 TLR2 TNFRSF12A TRIO TUBA4A UNKL USH1C USP6 VAV1 VAV2 VAV3 VWF WAS WASF1
Entrez ID 5058 5879
HPRD ID 03995 03627
Ensembl ID ENSG00000149269 ENSG00000136238
Uniprot IDs B3KNX7 Q13153 A4D2P0 A4D2P1 P63000
PDB IDs 1F3M 1YHV 1YHW 1ZSG 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC 1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2RMK 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD 3SBE 3SU8 3SUA 3TH5 4GZL 4GZM
Enriched GO Terms of Interacting Partners?
Tagcloud ?
advance  belonging  cdc2  cdc42  coordinate  coordinates  coordinating  cot1  delays  dystrophy  encodes  fission  genetically  interphase  maintain  maintains  mitosis  mitotic  morphogenesis  myotonic  orb2  orb6  p34  polarity  polarized  ras1  shape  shk1  threonine 
3t3  activate  bind  chimeric  cytoskeletal  dispensable  effector  effectors  interrelationship  jnk  jun  lamellipodia  lamellipodium  mediate  nh2  nih  p65  pak  ras  rho  rhoa  ruffling  srf  stimulate  surprisingly  threonine  transformation  transforming  tumorigenic 
Tagcloud (Difference) ?
advance  belonging  cdc2  cdc42  coordinate  coordinates  coordinating  cot1  delays  dystrophy  encodes  fission  genetically  interphase  maintain  maintains  mitosis  mitotic  morphogenesis  myotonic  orb2  orb6  p34  polarity  polarized  ras1  shape  shk1 
3t3  activate  bind  chimeric  cytoskeletal  dispensable  effector  effectors  interrelationship  jnk  jun  lamellipodia  lamellipodium  mediate  nh2  nih  p65  pak  ras  rho  rhoa  ruffling  srf  stimulate  surprisingly  transformation  transforming  tumorigenic 
Tagcloud (Intersection) ?
threonine