PAK1 and FOXL2

Number of citations of the paper that reports this interaction (PMID 12560069)
21

Data Source:
HPRD (in vitro, in vivo)

		PAK1	FOXL2
Gene Name		p21 protein (Cdc42/Rac)-activated kinase 1	forkhead box L2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Intercalated Disc Z Disc Axon Dendrite Growth Cone Filamentous Actin Nuclear Membrane Ruffle Membrane Protein Complex	Nucleus
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Kinase Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Estrogen Receptor Binding Ubiquitin Conjugating Enzyme Binding Cysteine-type Endopeptidase Regulator Activity Involved In Apoptotic Process Sequence-specific DNA Binding
	Biological Process	MAPK Cascade Mitotic Cell Cycle Response To Hypoxia Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Exocytosis Apoptotic Process Axon Guidance Neuromuscular Junction Development Dendrite Development Signal Transduction By Phosphorylation T Cell Costimulation Actin Cytoskeleton Reorganization Cellular Response To Insulin Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Wound Healing Receptor Clustering Positive Regulation Of JUN Kinase Activity Innate Immune Response Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis T Cell Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Cell Proliferation Involved In Contact Inhibition	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ovarian Follicle Development Extraocular Skeletal Muscle Development Apoptotic DNA Fragmentation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Female Somatic Sex Determination Cell Differentiation Menstruation Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Eye Morphogenesis Granulosa Cell Differentiation
Pathways		Axon guidance Costimulation by the CD28 family FCERI mediated MAPK activation L1CAM interactions VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Ephrin signaling Activation of Rac VEGFR2 mediated vascular permeability EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Generation of second messenger molecules Signal transduction by L1 Semaphorin interactions CD28 co-stimulation CD28 dependent Vav1 pathway TCR signaling DSCAM interactions Signaling by VEGF Sema3A PAK dependent Axon repulsion Fc epsilon receptor (FCERI) signaling Signaling by Robo receptor Adaptive Immune System
Drugs
Diseases
GWAS			Keloid ( 20711176)
Protein-Protein Interactions		83 interactors: ABI3 ACTA1 ACVR1 AKT1 APP ARHGEF2 ARHGEF6 ARHGEF7 ARPC1B BAD BAIAP2 BMPR1B BMX BRSK1 C5orf42 CASP1 CDC42 CDK11B CDK5 CDK5R1 CHORDC1 COL1A1 CRIPAK CSNK2A1 CSNK2A2 DSCAM DYNLL1 DYNLL2 DYRK1B EGFR ELF3 ERBB2 ESR1 FLNA FOXL2 FOXO1 FRS2 GIT2 GRB2 HGS HIST1H3A HIST1H4A HSP90AA1 LIMK1 MAP2K1 MAP3K1 MAPK1 MBP MYLK MYNN MYO6 NCK1 NCK2 NF2 OXSR1 PAK1IP1 PDPK1 PLCG1 PPM1F PRKCD PXN RAC1 RAF1 RHOJ RHOU SHC1 SMAD1 SMAD2 SMAD4 SMURF1 SORBS2 SORBS3 SYN1 TGFBR1 TGFBR2 TGM2 YWHAG YWHAZ ZBTB18 ZC3H7A ZNF418 ZNF823 ZNF83	3 interactors: LATS1 PAK1 SUMO1
Entrez ID		5058	668
HPRD ID		03995	05723
Ensembl ID		ENSG00000149269	ENSG00000183770
Uniprot IDs		B3KNX7 Q13153	P58012 Q53ZD3
PDB IDs		1F3M 1YHV 1YHW 1ZSG 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Anatomical Structure Morphogenesis Regulation Of Cellular Component Organization Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Differentiation Cell Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Anatomical Structure Development System Development Regulation Of Kinase Activity Intracellular Signal Transduction Developmental Process Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Process Regulation Of Organelle Organization Neurotrophin Signaling Pathway Regulation Of Protein Kinase Activity Multicellular Organismal Development Neurogenesis Axon Guidance Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Generation Of Neurons Axonogenesis Cell Communication Cell Projection Organization Tissue Development Cell Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Metabolic Process Signaling Neuron Projection Morphogenesis Axon Development Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Defense Response	Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Protein Localization PML Body Organization Cellular Response To Organic Substance Positive Regulation Of Cellular Component Biogenesis Protein Localization Regulation Of Cellular Component Organization Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Regulation Of Protein Complex Assembly Regulation Of Cellular Protein Metabolic Process Regulation Of Actin Cytoskeleton Organization Protein Localization To Nuclear Pore Protein Localization To Membrane Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Protein Localization To Nuclear Envelope Histone H3-T11 Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Actin Filament-based Process Cellular Localization Response To Organic Substance Regulation Of Cellular Ketone Metabolic Process Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Metabolic Process Contact Inhibition Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Signal Transduction Cellular Response To Hormone Stimulus Regulation Of Signaling Organelle Organization Cellular Protein Modification Process Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Response To Interferon-gamma Regulation Of Protein Kinase Activity Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hyperosmotic Response Positive Regulation Of Metabolic Process Cytoplasmic Sequestering Of Protein Protein Sumoylation Regulation Of Kinase Activity Regulation Of Protein Localization Hippo Signaling Innate Immune Response Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Membrane Organization Positive Regulation Of Phosphorylation
Tagcloud ?		advance belonging cdc2 cdc42 coordinate coordinates coordinating cot1 delays dystrophy encodes fission genetically interphase maintain maintains mitosis mitotic morphogenesis myotonic orb2 orb6 p34 polarity polarized ras1 shape shk1 threonine	4x180k benthic bioassays caeruleum customized cyp11a cyp19a1 darter disruptions dmrt1 effluent effluents esrb etheostoma gonad grand hatching intersex mwwes oogenesis outfalls ovulation pollutant polluted rainbow rbd spermatid suite vtg
Tagcloud (Difference) ?		advance belonging cdc2 cdc42 coordinate coordinates coordinating cot1 delays dystrophy encodes fission genetically interphase maintain maintains mitosis mitotic morphogenesis myotonic orb2 orb6 p34 polarity polarized ras1 shape shk1 threonine	4x180k benthic bioassays caeruleum customized cyp11a cyp19a1 darter disruptions dmrt1 effluent effluents esrb etheostoma gonad grand hatching intersex mwwes oogenesis outfalls ovulation pollutant polluted rainbow rbd spermatid suite vtg
Tagcloud (Intersection) ?