PAK1 and HACE1

Number of citations of the paper that reports this interaction (PubMedID 29362425)
56

Data Source:
BioGRID (enzymatic study)

		PAK1	HACE1
Description		p21 (RAC1) activated kinase 1	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Intercalated Disc Membrane Z Disc Lamellipodium Axon Dendrite Nuclear Membrane Ruffle Membrane Protein-containing Complex Cell Projection Anchoring Junction	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Membrane Nuclear Body Golgi Cisterna Membrane
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Collagen Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Small GTPase Binding Identical Protein Binding Gamma-tubulin Binding Protein Serine Kinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Small GTPase Binding Ubiquitin Protein Ligase Activity
	Biological Process	MAPK Cascade Response To Hypoxia Stimulatory C-type Lectin Receptor Signaling Pathway Chromatin Remodeling Exocytosis Apoptotic Process DNA Damage Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Fibroblast Migration Cell Migration Cerebellum Development Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Microtubule Polymerization Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Wound Healing Regulation Of MAPK Cascade Positive Regulation Of Axon Extension Positive Regulation Of Insulin Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Microtubule Nucleation Positive Regulation Of Protein Targeting To Membrane Regulation Of Actin Filament Organization Protein Localization To Cytoplasmic Stress Granule Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	Ubiquitin-dependent Protein Catabolic Process Golgi Organization Protein Ubiquitination Rac Protein Signal Transduction Regulation Of Cell Migration Membrane Fusion Protein K48-linked Ubiquitination
Pathways		Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation FCERI mediated MAPK activation FCERI mediated MAPK activation CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 Signal transduction by L1 Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PKNs RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Fostamatinib
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245) Tourette syndrome ( 30818990)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Age at voice drop ( 27182965) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Feeling guilty ( 29500382) Height ( 18391951) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29617998) Major depressive disorder ( 27479909) Menarche (age at onset) ( 27182965 19448622) Multiple sclerosis ( 23412934) Neuroblastoma ( 22941191) Obsessive-compulsive disorder ( 22889921) Resistant hypertension ( 31545351) Schizophrenia ( 28991256) Sporadic neuroblastoma ( 28545128) Thyroid stimulating hormone levels ( 17903292) Type 2 diabetes ( 31049640) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		89 interacting genes: ABI3 ACTA1 ACVR1 AKT1 APP ARHGEF2 ARHGEF6 ARHGEF7 ARPC1B BAD BAIAP2 BCL6 BMPR1B BMX BRSK1 BTG3 CASP1 CDC42 CDK11B CDK5 CDK5R1 CHORDC1 COL1A1 CPLANE1 CSNK2A1 CSNK2A2 DSCAM DSCR9 DYNLL1 DYNLL2 DYRK1B EGFR ELF3 ERBB2 ESR1 FLNA FOXL2 FOXO1 FRS2 GIT2 GRB2 H3C1 H4C1 HACE1 HGS HSP90AA1 KEAP1 LIMK1 MAP2K1 MAP3K1 MAPK1 MBP MYLK MYNN MYO6 NCK1 NCK2 NF2 OXSR1 PAK1IP1 PDPK1 PLCG1 PPM1A PPM1F PPP1CA PPP2CA PRKCD PXN RAC1 RAF1 RHOJ RHOU SHC1 SMAD1 SMAD2 SMAD4 SMURF1 SORBS2 SYN1 TGFBR1 TGFBR2 TGM2 YWHAG YWHAZ ZBTB18 ZC3H7A ZNF418 ZNF823 ZNF83	10 interacting genes: CCNC MTDH OPTN PAK1 PLXNA2 RAB4A RAC1 SNTG2 UBE2D2 UBE2L3
Entrez ID		5058	57531
HPRD ID		03995	17086
Ensembl ID		ENSG00000149269	ENSG00000085382
Uniprot IDs		B3KNX7 E9PM17 Q13153	Q8IYU2
PDB IDs		1F3M 1YHV 1YHW 1ZSG 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC 4O0R 4O0T 4P90 4ZJI 4ZJJ 4ZLO 4ZY4 4ZY5 4ZY6 5DEW 5DEY 5DFP 5IME 5KBQ 5KBR 6B16 7VTO 8X5Z	8H8X 8HAE 8PWL 8Q0N
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Protein Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Signal Transduction Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of Developmental Process Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Multicellular Organismal Process Response To Growth Factor Regulation Of Signal Transduction Anatomical Structure Morphogenesis Regulation Of Supramolecular Fiber Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Protein Phosphorylation ERBB Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Locomotion Focal Adhesion Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Lamellipodium Phosphorylation Regulation Of Anatomical Structure Morphogenesis Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Motility Protein Kinase Binding Regulation Of Locomotion Cytosol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cellular Component Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Cell Migration Developmental Process Regulation Of Cytoskeleton Organization Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Protein Localization	Hepatocyte Growth Factor Receptor Signaling Pathway Recycling Endosome Membrane Regulation Of Fibroblast Migration Positive Regulation Of Microtubule Polymerization Semaphorin-plexin Signaling Pathway Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Protein Polymerization Regulation Of Microtubule Polymerization Positive Regulation Of Stress Fiber Assembly Actin Filament Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Actin Filament Bundle Assembly Cerebellar Granule Cell Precursor Tangential Migration G Protein Activity Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Nucleotide Binding Regulation Of Microtubule Polymerization Or Depolymerization Ruffle Membrane Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Regulation Of Stress Fiber Assembly Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis
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