PAK1 and MYO6

Number of citations of the paper that reports this interaction (PubMedID 9852149)
71

Data Source:
BioGRID (enzymatic study)

		PAK1	MYO6
Description		p21 (RAC1) activated kinase 1	myosin VI
Image
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Intercalated Disc Membrane Z Disc Lamellipodium Axon Dendrite Nuclear Membrane Ruffle Membrane Protein-containing Complex Cell Projection Anchoring Junction	Ruffle Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Endosome Autophagosome Golgi Apparatus Cytosol Actin Filament Plasma Membrane Microvillus Clathrin-coated Pit Cell Cortex Actin Cytoskeleton Membrane Myosin Complex Unconventional Myosin Complex Clathrin-coated Vesicle Endocytic Vesicle Filopodium Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Filamentous Actin Nuclear Membrane Ruffle Membrane Protein-containing Complex Cell Projection Apical Part Of Cell Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Collagen Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Small GTPase Binding Identical Protein Binding Gamma-tubulin Binding Protein Serine Kinase Activity	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding ADP Binding Actin Filament Binding Minus-end Directed Microfilament Motor Activity
	Biological Process	MAPK Cascade Response To Hypoxia Stimulatory C-type Lectin Receptor Signaling Pathway Chromatin Remodeling Exocytosis Apoptotic Process DNA Damage Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Fibroblast Migration Cell Migration Cerebellum Development Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Microtubule Polymerization Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Wound Healing Regulation Of MAPK Cascade Positive Regulation Of Axon Extension Positive Regulation Of Insulin Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Microtubule Nucleation Positive Regulation Of Protein Targeting To Membrane Regulation Of Actin Filament Organization Protein Localization To Cytoplasmic Stress Granule Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	Intracellular Protein Transport Endocytosis Actin Filament Organization Sensory Perception Of Sound Intracellular Protein Localization Response To Xenobiotic Stimulus Protein Transport Actin Filament-based Movement DNA Damage Response, Signal Transduction By P53 Class Mediator Inner Ear Morphogenesis Inner Ear Auditory Receptor Cell Differentiation Regulation Of Secretion
Pathways		Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation FCERI mediated MAPK activation FCERI mediated MAPK activation CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 Signal transduction by L1 Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PKNs RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	Gap junction degradation Trafficking of AMPA receptors RHOBTB2 GTPase cycle RHOU GTPase cycle RHOBTB1 GTPase cycle
Drugs		Fostamatinib
Diseases			Deafness, autosomal recessive Deafness, autosomal dominant
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245) Tourette syndrome ( 30818990)	Hip circumference adjusted for BMI ( 34021172) Prostate cancer ( 25217961) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		89 interacting genes: ABI3 ACTA1 ACVR1 AKT1 APP ARHGEF2 ARHGEF6 ARHGEF7 ARPC1B BAD BAIAP2 BCL6 BMPR1B BMX BRSK1 BTG3 CASP1 CDC42 CDK11B CDK5 CDK5R1 CHORDC1 COL1A1 CPLANE1 CSNK2A1 CSNK2A2 DSCAM DSCR9 DYNLL1 DYNLL2 DYRK1B EGFR ELF3 ERBB2 ESR1 FLNA FOXL2 FOXO1 FRS2 GIT2 GRB2 H3C1 H4C1 HACE1 HGS HSP90AA1 KEAP1 LIMK1 MAP2K1 MAP3K1 MAPK1 MBP MYLK MYNN MYO6 NCK1 NCK2 NF2 OXSR1 PAK1IP1 PDPK1 PLCG1 PPM1A PPM1F PPP1CA PPP2CA PRKCD PXN RAC1 RAF1 RHOJ RHOU SHC1 SMAD1 SMAD2 SMAD4 SMURF1 SORBS2 SYN1 TGFBR1 TGFBR2 TGM2 YWHAG YWHAZ ZBTB18 ZC3H7A ZNF418 ZNF823 ZNF83	24 interacting genes: ACTA1 APC CALCOCO2 CALM2 CDC42 CDH1 CLTB DAB1 DAB2 DLG1 GIPC1 LRCH3 OPTN PAK1 PAK3 PRMT2 RNF11 RNF26 SEPTIN9 SNCA TAX1BP1 TOM1L2 UBC WBP2
Entrez ID		5058	4646
HPRD ID		03995	02985
Ensembl ID		ENSG00000149269	ENSG00000196586
Uniprot IDs		B3KNX7 E9PM17 Q13153	A0A0A0MRM8 A0A1Y0BRN3 A0A590UJ40 Q9UM54
PDB IDs		1F3M 1YHV 1YHW 1ZSG 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC 4O0R 4O0T 4P90 4ZJI 4ZJJ 4ZLO 4ZY4 4ZY5 4ZY6 5DEW 5DEY 5DFP 5IME 5KBQ 5KBR 6B16 7VTO 8X5Z	2N0Z 2N10 2N11 2N12 2N13 6E5N 6J56 8W41
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Protein Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Signal Transduction Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of Developmental Process Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Multicellular Organismal Process Response To Growth Factor Regulation Of Signal Transduction Anatomical Structure Morphogenesis Regulation Of Supramolecular Fiber Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Protein Phosphorylation ERBB Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Locomotion Focal Adhesion Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Lamellipodium Phosphorylation Regulation Of Anatomical Structure Morphogenesis Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Motility Protein Kinase Binding Regulation Of Locomotion Cytosol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cellular Component Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Cell Migration Developmental Process Regulation Of Cytoskeleton Organization Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Protein Localization	Perinuclear Region Of Cytoplasm Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Cytoplasm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Intracellular Protein Localization Regulation Of Supramolecular Fiber Organization Cytosol Regulation Of Organelle Organization Septin Cytoskeleton Organization Protein Kinase Binding Cell Junction Organization Presynaptic Endocytosis Negative Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Cell Cycle Process Regulation Of Axonogenesis Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Cadherin Binding Regulation Of Cytoskeleton Organization Leading Edge Membrane Cell-cell Junction Organization Positive Regulation Of Cellular Component Organization Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Glutamatergic Synapse Regulation Of Defense Response Lateral Plasma Membrane Negative Regulation Of Cell Cycle G1/S Phase Transition Gamma-catenin Binding Lamellipodium Positive Regulation Of Pseudopodium Assembly Regulation Of Protein Catabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Cell Migration Golgi Localization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Mitotic Cell Cycle Autophagosome Regulation Of Cytokinesis Regulation Of Protein-containing Complex Assembly Vesicle-mediated Transport In Synapse Dendritic Spine Morphogenesis Regulation Of Neuron Projection Development Endocytosis Regulation Of Microtubule Polymerization Or Depolymerization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?