PAK1 and MYO6

Number of citations of the paper that reports this interaction (PMID 9852149)
47

Data Source:
BioGRID (enzymatic study)

		PAK1	MYO6
Gene Name		p21 protein (Cdc42/Rac)-activated kinase 1	myosin VI
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Intercalated Disc Z Disc Axon Dendrite Growth Cone Filamentous Actin Nuclear Membrane Ruffle Membrane Protein Complex	Ruffle Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Microvillus Coated Pit Cell Cortex Membrane Cytoplasmic Membrane-bounded Vesicle Unconventional Myosin Complex DNA-directed RNA Polymerase II, Holoenzyme Endocytic Vesicle Axon Clathrin-coated Vesicle Membrane Filamentous Actin Nuclear Membrane Ruffle Membrane Neuronal Cell Body Apical Part Of Cell Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Kinase Binding	Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ADP Binding Actin Filament Binding Minus-end Directed Microfilament Motor Activity
	Biological Process	MAPK Cascade Mitotic Cell Cycle Response To Hypoxia Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Exocytosis Apoptotic Process Axon Guidance Neuromuscular Junction Development Dendrite Development Signal Transduction By Phosphorylation T Cell Costimulation Actin Cytoskeleton Reorganization Cellular Response To Insulin Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Wound Healing Receptor Clustering Positive Regulation Of JUN Kinase Activity Innate Immune Response Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis T Cell Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Cell Proliferation Involved In Contact Inhibition	Protein Targeting Intracellular Protein Transport Endocytosis Synaptic Transmission Synapse Assembly Sensory Perception Of Sound Locomotory Behavior Metabolic Process Glutamate Secretion Dendrite Development Actin Filament-based Movement DNA Damage Response, Signal Transduction By P53 Class Mediator Inner Ear Morphogenesis Auditory Receptor Cell Differentiation Response To Drug Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Synaptic Plasticity Regulation Of Secretion Membrane Organization Cellular Response To Electrical Stimulus
Pathways		Axon guidance Costimulation by the CD28 family FCERI mediated MAPK activation L1CAM interactions VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Ephrin signaling Activation of Rac VEGFR2 mediated vascular permeability EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Generation of second messenger molecules Signal transduction by L1 Semaphorin interactions CD28 co-stimulation CD28 dependent Vav1 pathway TCR signaling DSCAM interactions Signaling by VEGF Sema3A PAK dependent Axon repulsion Fc epsilon receptor (FCERI) signaling Signaling by Robo receptor Adaptive Immune System	Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Hypertension ( 21626137)
Protein-Protein Interactions		83 interactors: ABI3 ACTA1 ACVR1 AKT1 APP ARHGEF2 ARHGEF6 ARHGEF7 ARPC1B BAD BAIAP2 BMPR1B BMX BRSK1 C5orf42 CASP1 CDC42 CDK11B CDK5 CDK5R1 CHORDC1 COL1A1 CRIPAK CSNK2A1 CSNK2A2 DSCAM DYNLL1 DYNLL2 DYRK1B EGFR ELF3 ERBB2 ESR1 FLNA FOXL2 FOXO1 FRS2 GIT2 GRB2 HGS HIST1H3A HIST1H4A HSP90AA1 LIMK1 MAP2K1 MAP3K1 MAPK1 MBP MYLK MYNN MYO6 NCK1 NCK2 NF2 OXSR1 PAK1IP1 PDPK1 PLCG1 PPM1F PRKCD PXN RAC1 RAF1 RHOJ RHOU SHC1 SMAD1 SMAD2 SMAD4 SMURF1 SORBS2 SORBS3 SYN1 TGFBR1 TGFBR2 TGM2 YWHAG YWHAZ ZBTB18 ZC3H7A ZNF418 ZNF823 ZNF83	17 interactors: ACTA1 AP2A1 APC CALCOCO2 CALM2 CDC42 DAB1 DAB2 DLG1 GIPC1 OPTN PAK1 PAK3 RNF11 TAX1BP1 TOM1 TOM1L2
Entrez ID		5058	4646
HPRD ID		03995	02985
Ensembl ID		ENSG00000149269	ENSG00000196586
Uniprot IDs		B3KNX7 Q13153	Q9UM54
PDB IDs		1F3M 1YHV 1YHW 1ZSG 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Anatomical Structure Morphogenesis Regulation Of Cellular Component Organization Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Differentiation Cell Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Anatomical Structure Development System Development Regulation Of Kinase Activity Intracellular Signal Transduction Developmental Process Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Process Regulation Of Organelle Organization Neurotrophin Signaling Pathway Regulation Of Protein Kinase Activity Multicellular Organismal Development Neurogenesis Axon Guidance Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Generation Of Neurons Axonogenesis Cell Communication Cell Projection Organization Tissue Development Cell Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Metabolic Process Signaling Neuron Projection Morphogenesis Axon Development Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Defense Response	Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Cell Adhesion Movement Of Cell Or Subcellular Component Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Cell Morphogenesis Involved In Differentiation Regulation Of Signal Transduction Immune System Process Positive Regulation Of Protein Kinase Activity Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Division Neuron Projection Development Positive Regulation Of Protein Metabolic Process Locomotion Regulation Of Signaling Positive Regulation Of Phosphorylation Cellular Localization Cell Development Axonogenesis Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Cellular Protein Localization Protein Localization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Neuron Projection Morphogenesis Cell Morphogenesis Positive Regulation Of Cell Adhesion Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Axon Guidance Positive Regulation Of Cellular Protein Metabolic Process Neuron Differentiation Response To Stimulus Cell Projection Organization Negative Regulation Of Signaling Regulation Of Cytokinesis Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Response To External Stimulus Cell Projection Morphogenesis Regulation Of Immune System Process Regulation Of Cell Cycle Process
Tagcloud ?		advance belonging cdc2 cdc42 coordinate coordinates coordinating cot1 delays dystrophy encodes fission genetically interphase maintain maintains mitosis mitotic morphogenesis myotonic orb2 orb6 p34 polarity polarized ras1 shape shk1 threonine	109qmhtt 410delta 520delta 81qnmhtt autophagosome autophagosomes colocalize d474n e478g e50k htt huntingtin ibs interfered k63 mhtt myb1 neuro2a optineurin optn polyubiquitin polyubiquitinated puncta r6 tardbpnd251 tom1 ubbd ubbddelta weakened
Tagcloud (Difference) ?		advance belonging cdc2 cdc42 coordinate coordinates coordinating cot1 delays dystrophy encodes fission genetically interphase maintain maintains mitosis mitotic morphogenesis myotonic orb2 orb6 p34 polarity polarized ras1 shape shk1 threonine	109qmhtt 410delta 520delta 81qnmhtt autophagosome autophagosomes colocalize d474n e478g e50k htt huntingtin ibs interfered k63 mhtt myb1 neuro2a optineurin optn polyubiquitin polyubiquitinated puncta r6 tardbpnd251 tom1 ubbd ubbddelta weakened
Tagcloud (Intersection) ?