PLCG1 and KIT

Number of citations of the paper that reports this interaction (PMID 7536744)
3

Data Source:
HPRD (in vivo)

		PLCG1	KIT
Gene Name		phospholipase C, gamma 1	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Image
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane Cell-cell Junction COP9 Signalosome Lamellipodium Cell Projection	Acrosomal Vesicle Extracellular Space Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Integral Component Of Membrane Mast Cell Granule
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Receptor Signaling Protein Activity Neurotrophin TRKA Receptor Binding Calcium Ion Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Glutamate Receptor Binding	Protease Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Stem Cell Factor Receptor Activity Protein Binding ATP Binding Cytokine Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Activation Of MAPKK Activity In Utero Embryonic Development Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Axon Guidance Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Phospholipid Catabolic Process Positive Regulation Of Epithelial Cell Migration Viral Process Cell Migration Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Blood Vessel Endothelial Cell Migration Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway T Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Epidermal Growth Factor Stimulus	Activation Of MAPK Activity Ovarian Follicle Development Myeloid Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Immature B Cell Differentiation Dendritic Cell Cytokine Production Mast Cell Chemotaxis Glycosphingolipid Metabolic Process Inflammatory Response Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Spermatogenesis Spermatid Development Positive Regulation Of Cell Proliferation Germ Cell Migration Regulation Of Cell Shape Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Positive Regulation Of Gene Expression Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Stem Cell Maintenance Signal Transduction By Phosphorylation Lamellipodium Assembly Hemopoiesis T Cell Differentiation Erythrocyte Differentiation Melanocyte Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Actin Cytoskeleton Reorganization Mast Cell Cytokine Production Somatic Stem Cell Maintenance Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Megakaryocyte Development Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Programmed Cell Death Mast Cell Degranulation Positive Regulation Of MAPK Cascade Pigmentation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Notch Signaling Pathway Positive Regulation Of JAK-STAT Cascade Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Developmental Pigmentation Somatic Stem Cell Division Positive Regulation Of Long-term Neuronal Synaptic Plasticity Digestive Tract Development Stem Cell Differentiation Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell Chemotaxis Mast Cell Differentiation Mast Cell Proliferation Cellular Response To Thyroid Hormone Stimulus Melanocyte Migration Melanocyte Adhesion
Pathways		Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAP12 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Synthesis of IP3 and IP4 in the cytosol Signaling by FGFR1 mutants Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Inositol phosphate metabolism Antiviral mechanism by IFN-stimulated genes EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR TCR signaling Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Signaling by FGFR mutants Frs2-mediated activation Adaptive Immune System Signalling to ERKs Prolonged ERK activation events Axon guidance DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Netrin-1 signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF Generation of second messenger molecules ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PECAM1 interactions Cell surface interactions at the vascular wall Role of second messengers in netrin-1 signaling PLC-gamma1 signalling FCERI mediated Ca+2 mobilization Constitutive Signaling by EGFRvIII Signaling by FGFR1 fusion mutants	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Regulation of KIT signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs			Sorafenib Imatinib Dasatinib Sunitinib Phosphonotyrosine Adenosine-5\'-Diphosphate Nilotinib Pazopanib Regorafenib Ponatinib
Diseases
GWAS			Bipolar disorder ( 19416921) Mean corpuscular volume ( 20139978 19862010) Red blood cell traits ( 23222517)
Protein-Protein Interactions		106 interactors: ABL1 AGAP2 AGTR1 AKT1 ALK ARHGAP32 ARHGEF5 AXL BAG3 BCR BLNK BTK CBL CD22 CD28 CTSS DAB1 DAPP1 DDR1 DGKZ DNM1 DOK1 EEF1A1 EGFR EPHB2 EPOR ERBB2 ERBB3 FGFR1 FGFR2 FGFR4 FLT1 FYN GAB1 GAB2 GHR GIT1 GNB2L1 GRAP GRB2 GRIN1 GRIN2A GRIN2B GSN GTF2H1 HCK INPP5D INSR IRS2 ITK KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LIFR LYN MET MST1R NCAM1 NCK1 NPM1 NTRK1 NTRK2 NTRK3 PAK1 PDGFRA PDGFRB PECAM1 PICALM PITPNA PKN2 PLD2 PRKD1 PTK2 PTPN11 PTPRJ RET RHOA RHOU SELE SH2D2A SH3BP2 SHB SHC1 SNAP91 SOCS7 SOS1 SOS2 SRC SYK SYN1 SYNCRIP TEC TNK1 TRPC3 TRPM7 TUB USO1 VAV1 VAV3 VIL1 WAS ZAP70	56 interactors: ABL1 BTK CBL CBLB CD81 CD9 CISH CLTC CRK CRKL CSF2RA CSF2RB DOK1 EPOR FYN GRAP GRAP2 GRB10 GRB2 GRB7 HCK IL7R INPP5D JAK2 JAK3 KITLG LCK LYN MATK MPDZ PIK3CG PIK3R1 PIK3R2 PLCE1 PLCG1 PRKCA PRKCB PTPN11 PTPN6 PTPRO PTPRU RASA1 SH2B2 SH2B3 SOCS1 SOCS5 SOCS6 SPRED1 SPRED2 SRC STAP1 STAT1 STAT5A STAT5B TEC YES1
Entrez ID		5335	3815
HPRD ID		01398	01287
Ensembl ID		ENSG00000124181	ENSG00000157404
Uniprot IDs		P19174 Q4LE43 Q9UFY1	P10721
PDB IDs		1HSQ 2HSP 4EY0 4FBN	1PKG 1QZJ 1QZK 1R01 1T45 1T46 2E9W 2EC8 2VIF 3G0E 3G0F 4HVS
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Signaling Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Locomotion Protein Autophosphorylation Fc Receptor Signaling Pathway Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Immune Response-regulating Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Innate Immune Response Regulation Of Signal Transduction Response To Stimulus Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cell Migration Cell Motility Response To Organic Substance Defense Response Regulation Of Immune Response Immune Response Chemotaxis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin Signaling Pathway Peptidyl-amino Acid Modification Cellular Response To Growth Factor Stimulus Immune System Process Response To Wounding Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Regulation Of Immune System Process Cellular Response To Organic Substance Developmental Process Response To External Stimulus Wound Healing Protein Phosphorylation Regulation Of Catalytic Activity Phosphatidylinositol-mediated Signaling Cell Differentiation Regulation Of Cell Proliferation Peptidyl-tyrosine Autophosphorylation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Immune Response Regulation Of Immune System Process Response To Peptide Hormone Positive Regulation Of Immune System Process Signal Transduction Cellular Response To Organonitrogen Compound Intracellular Signal Transduction Cellular Response To Organic Substance Response To Peptide Regulation Of Body Fluid Levels Response To Organic Substance Immune System Process Signaling Regulation Of Cell Activation Cell Communication Cellular Response To Hormone Stimulus Blood Coagulation Hemostasis Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell Activation Positive Regulation Of Signal Transduction Regulation Of Cell-cell Adhesion Wound Healing Regulation Of Signaling Innate Immune Response Regulation Of Cell Adhesion Response To Organonitrogen Compound Regulation Of Lymphocyte Activation Response To Hormone Immune Response-regulating Signaling Pathway Cellular Response To Stimulus Leukocyte Migration Immune Response Response To Wounding Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Positive Regulation Of Immune Response Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of T Cell Activation
Tagcloud ?		13b adjusting associations card11 clear consortium correcting determinants endometrioid eoc highlight histologies histology immunity inherited member modulating mucinous note phospholipase rs11696662 rs17250239 rs41324349 rs7501462 serous superfamily threshold tnfrsf13b traf2	advantage blast blasts cd34 clonal clusters colonies continuously csf cytokines granulocyte immunomagnetic leukemic macrophage microspheres ng physiologic progenitor purified rg rgm ril rm rscf saturating scf subdivided supported undifferentiated
Tagcloud (Difference) ?		13b adjusting associations card11 clear consortium correcting determinants endometrioid eoc highlight histologies histology immunity inherited member modulating mucinous note phospholipase rs11696662 rs17250239 rs41324349 rs7501462 serous superfamily threshold tnfrsf13b traf2	advantage blast blasts cd34 clonal clusters colonies continuously csf cytokines granulocyte immunomagnetic leukemic macrophage microspheres ng physiologic progenitor purified rg rgm ril rm rscf saturating scf subdivided supported undifferentiated
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