PLCG1 and IRS2

Number of citations of the paper that reports this interaction (PMID 9535722)
4

Data Source:
HPRD (in vivo)

		PLCG1	IRS2
Gene Name		phospholipase C, gamma 1	insulin receptor substrate 2
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Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane Cell-cell Junction COP9 Signalosome Lamellipodium Cell Projection	Cytosol Plasma Membrane
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Receptor Signaling Protein Activity Neurotrophin TRKA Receptor Binding Calcium Ion Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Glutamate Receptor Binding	Signal Transducer Activity Insulin Receptor Binding Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Phosphatidylinositol 3-kinase Binding 14-3-3 Protein Binding
	Biological Process	Activation Of MAPKK Activity In Utero Embryonic Development Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Axon Guidance Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Phospholipid Catabolic Process Positive Regulation Of Epithelial Cell Migration Viral Process Cell Migration Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Blood Vessel Endothelial Cell Migration Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway T Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Epidermal Growth Factor Stimulus	Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of B Cell Apoptotic Process Glucose Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Brain Development Cell Proliferation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Glucose Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Positive Regulation Of Glucose Metabolic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Cell Migration Mammary Gland Development Positive Regulation Of B Cell Proliferation Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Negative Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Lipid Homeostasis JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Glucose Stimulus
Pathways		Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAP12 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Synthesis of IP3 and IP4 in the cytosol Signaling by FGFR1 mutants Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Inositol phosphate metabolism Antiviral mechanism by IFN-stimulated genes EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR TCR signaling Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Signaling by FGFR mutants Frs2-mediated activation Adaptive Immune System Signalling to ERKs Prolonged ERK activation events Axon guidance DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Netrin-1 signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF Generation of second messenger molecules ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PECAM1 interactions Cell surface interactions at the vascular wall Role of second messengers in netrin-1 signaling PLC-gamma1 signalling FCERI mediated Ca+2 mobilization Constitutive Signaling by EGFRvIII Signaling by FGFR1 fusion mutants	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade SOS-mediated signalling PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Signaling by Leptin Growth hormone receptor signaling Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS activation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs
Diseases
GWAS
Protein-Protein Interactions		106 interactors: ABL1 AGAP2 AGTR1 AKT1 ALK ARHGAP32 ARHGEF5 AXL BAG3 BCR BLNK BTK CBL CD22 CD28 CTSS DAB1 DAPP1 DDR1 DGKZ DNM1 DOK1 EEF1A1 EGFR EPHB2 EPOR ERBB2 ERBB3 FGFR1 FGFR2 FGFR4 FLT1 FYN GAB1 GAB2 GHR GIT1 GNB2L1 GRAP GRB2 GRIN1 GRIN2A GRIN2B GSN GTF2H1 HCK INPP5D INSR IRS2 ITK KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LIFR LYN MET MST1R NCAM1 NCK1 NPM1 NTRK1 NTRK2 NTRK3 PAK1 PDGFRA PDGFRB PECAM1 PICALM PITPNA PKN2 PLD2 PRKD1 PTK2 PTPN11 PTPRJ RET RHOA RHOU SELE SH2D2A SH3BP2 SHB SHC1 SNAP91 SOCS7 SOS1 SOS2 SRC SYK SYN1 SYNCRIP TEC TNK1 TRPC3 TRPM7 TUB USO1 VAV1 VAV3 VIL1 WAS ZAP70	38 interactors: ATP2A1 ATP2A2 BCL2L1 CRK EPOR FES GRB2 IGF1R IL4R INSR JAK1 JAK2 JAK3 MPL NTRK1 PIK3CA PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 PTPN6 PTPRF RPTOR SHC1 SIRT1 SOCS1 SOCS3 SOCS6 SOCS7 TYK2 UBTF YWHAB YWHAE YWHAG YWHAQ YWHAZ
Entrez ID		5335	8660
HPRD ID		01398	02878
Ensembl ID		ENSG00000124181	ENSG00000185950
Uniprot IDs		P19174 Q4LE43 Q9UFY1	Q9P084 Q9Y4H2
PDB IDs		1HSQ 2HSP 4EY0 4FBN	3FQW 3FQX
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Signaling Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Locomotion Protein Autophosphorylation Fc Receptor Signaling Pathway Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Immune Response-regulating Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Innate Immune Response Regulation Of Signal Transduction Response To Stimulus Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cell Migration Cell Motility Response To Organic Substance Defense Response Regulation Of Immune Response Immune Response Chemotaxis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin Signaling Pathway Peptidyl-amino Acid Modification Cellular Response To Growth Factor Stimulus Immune System Process Response To Wounding Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Regulation Of Immune System Process Cellular Response To Organic Substance Developmental Process Response To External Stimulus Wound Healing Protein Phosphorylation Regulation Of Catalytic Activity Phosphatidylinositol-mediated Signaling Cell Differentiation Regulation Of Cell Proliferation Peptidyl-tyrosine Autophosphorylation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Cellular Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Cellular Response To Organic Substance Cellular Response To Peptide Response To Peptide Hormone Response To Peptide Response To Organonitrogen Compound Response To Organic Substance Signal Transduction Cellular Response To Hormone Stimulus Signaling Cell Communication Insulin Receptor Signaling Pathway Regulation Of Kinase Activity Response To Hormone Cellular Response To Insulin Stimulus Cell Surface Receptor Signaling Pathway Response To Insulin Cellular Response To Stimulus Regulation Of Immune Response Regulation Of Phosphorus Metabolic Process Immune Response Regulation Of Phosphorylation Innate Immune Response Defense Response Regulation Of Protein Kinase Activity Response To Stress Regulation Of Signal Transduction Regulation Of Immune System Process Response To Stimulus Regulation Of Signaling Positive Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Blood Coagulation Hemostasis Cytokine-mediated Signaling Pathway Response To Cytokine Immune System Process Cellular Response To Cytokine Stimulus Regulation Of Protein Phosphorylation Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Response To Wounding Regulation Of Intracellular Transport ERBB Signaling Pathway Locomotion
Tagcloud ?		13b adjusting associations card11 clear consortium correcting determinants endometrioid eoc highlight histologies histology immunity inherited member modulating mucinous note phospholipase rs11696662 rs17250239 rs41324349 rs7501462 serous superfamily threshold tnfrsf13b traf2	aacr adaptive adaptor compensatory conversely cotargeting dampen dasatinib ddr2 driven emerged gab1 harboring igf1r implicating library met option overlaying panel phosphoproteomics py rationale res rescued rtk scc synergistic weakly
Tagcloud (Difference) ?		13b adjusting associations card11 clear consortium correcting determinants endometrioid eoc highlight histologies histology immunity inherited member modulating mucinous note phospholipase rs11696662 rs17250239 rs41324349 rs7501462 serous superfamily threshold tnfrsf13b traf2	aacr adaptive adaptor compensatory conversely cotargeting dampen dasatinib ddr2 driven emerged gab1 harboring igf1r implicating library met option overlaying panel phosphoproteomics py rationale res rescued rtk scc synergistic weakly
Tagcloud (Intersection) ?