PLCG1 and SOS2

Number of citations of the paper that reports this interaction (PMID 10940929)
1

Data Source:
HPRD (two hybrid, in vivo)

		PLCG1	SOS2
Gene Name		phospholipase C, gamma 1	son of sevenless homolog 2 (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane Cell-cell Junction COP9 Signalosome Lamellipodium Cell Projection	Cytosol
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Receptor Signaling Protein Activity Neurotrophin TRKA Receptor Binding Calcium Ion Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Glutamate Receptor Binding	DNA Binding Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Activation Of MAPKK Activity In Utero Embryonic Development Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Axon Guidance Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Phospholipid Catabolic Process Positive Regulation Of Epithelial Cell Migration Viral Process Cell Migration Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Blood Vessel Endothelial Cell Migration Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway T Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Epidermal Growth Factor Stimulus	Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAP12 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Synthesis of IP3 and IP4 in the cytosol Signaling by FGFR1 mutants Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Inositol phosphate metabolism Antiviral mechanism by IFN-stimulated genes EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR TCR signaling Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Signaling by FGFR mutants Frs2-mediated activation Adaptive Immune System Signalling to ERKs Prolonged ERK activation events Axon guidance DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Netrin-1 signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF Generation of second messenger molecules ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PECAM1 interactions Cell surface interactions at the vascular wall Role of second messengers in netrin-1 signaling PLC-gamma1 signalling FCERI mediated Ca+2 mobilization Constitutive Signaling by EGFRvIII Signaling by FGFR1 fusion mutants	Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling Activation of Rac NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Signaling by Robo receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		106 interactors: ABL1 AGAP2 AGTR1 AKT1 ALK ARHGAP32 ARHGEF5 AXL BAG3 BCR BLNK BTK CBL CD22 CD28 CTSS DAB1 DAPP1 DDR1 DGKZ DNM1 DOK1 EEF1A1 EGFR EPHB2 EPOR ERBB2 ERBB3 FGFR1 FGFR2 FGFR4 FLT1 FYN GAB1 GAB2 GHR GIT1 GNB2L1 GRAP GRB2 GRIN1 GRIN2A GRIN2B GSN GTF2H1 HCK INPP5D INSR IRS2 ITK KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LIFR LYN MET MST1R NCAM1 NCK1 NPM1 NTRK1 NTRK2 NTRK3 PAK1 PDGFRA PDGFRB PECAM1 PICALM PITPNA PKN2 PLD2 PRKD1 PTK2 PTPN11 PTPRJ RET RHOA RHOU SELE SH2D2A SH3BP2 SHB SHC1 SNAP91 SOCS7 SOS1 SOS2 SRC SYK SYN1 SYNCRIP TEC TNK1 TRPC3 TRPM7 TUB USO1 VAV1 VAV3 VIL1 WAS ZAP70	16 interactors: ABI1 ABL1 BIN1 CD2AP CRKL EGFR GRAP2 GRB2 HRAS ITSN2 PACSIN3 PLCG1 SH3D19 SHC1 SNX18 SNX9
Entrez ID		5335	6655
HPRD ID		01398	03149
Ensembl ID		ENSG00000124181	ENSG00000100485
Uniprot IDs		P19174 Q4LE43 Q9UFY1	B7ZKT6 Q07890
PDB IDs		1HSQ 2HSP 4EY0 4FBN
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Signaling Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Locomotion Protein Autophosphorylation Fc Receptor Signaling Pathway Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Immune Response-regulating Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Innate Immune Response Regulation Of Signal Transduction Response To Stimulus Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cell Migration Cell Motility Response To Organic Substance Defense Response Regulation Of Immune Response Immune Response Chemotaxis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin Signaling Pathway Peptidyl-amino Acid Modification Cellular Response To Growth Factor Stimulus Immune System Process Response To Wounding Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Regulation Of Immune System Process Cellular Response To Organic Substance Developmental Process Response To External Stimulus Wound Healing Protein Phosphorylation Regulation Of Catalytic Activity Phosphatidylinositol-mediated Signaling Cell Differentiation Regulation Of Cell Proliferation Peptidyl-tyrosine Autophosphorylation	Endocytosis Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Positive Regulation Of Metabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Innate Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Catalytic Activity Regulation Of Immune Response Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Activation Of MAPKK Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Hydrolase Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Ras Protein Signal Transduction Positive Regulation Of MAPK Cascade Lipid Tube Assembly Cell Migration Immune Response Regulation Of Immune System Process Activation Of Protein Kinase Activity Defense Response Immune Response-activating Cell Surface Receptor Signaling Pathway
Tagcloud ?		13b adjusting associations card11 clear consortium correcting determinants endometrioid eoc highlight histologies histology immunity inherited member modulating mucinous note phospholipase rs11696662 rs17250239 rs41324349 rs7501462 serous superfamily threshold tnfrsf13b traf2	arnt bio biogrid bmpr1b crebl dijkstra ecm etc greedy hsc hscs integrative iterative kegg map2k1 nf1 pik3r3 ppp2r1a prkca searching smad2 stellate targetome tfs tranfac transcriptome transcriptomic uncovered underlie
Tagcloud (Difference) ?		13b adjusting associations card11 clear consortium correcting determinants endometrioid eoc highlight histologies histology immunity inherited member modulating mucinous note phospholipase rs11696662 rs17250239 rs41324349 rs7501462 serous superfamily threshold tnfrsf13b traf2	arnt bio biogrid bmpr1b crebl dijkstra ecm etc greedy hsc hscs integrative iterative kegg map2k1 nf1 pik3r3 ppp2r1a prkca searching smad2 stellate targetome tfs tranfac transcriptome transcriptomic uncovered underlie
Tagcloud (Intersection) ?