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PLCG1 and MET
Number of citations of the paper that reports this interaction (PubMedID
24728074
)
77
Data Source:
BioGRID
(pull down)
HPRD
(in vitro)
PLCG1
MET
Description
phospholipase C gamma 1
MET proto-oncogene, receptor tyrosine kinase
Image
GO Annotations
Cellular Component
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
COP9 Signalosome
Lamellipodium
Ruffle Membrane
Cell Projection
Extracellular Region
Plasma Membrane
Basal Plasma Membrane
Cell Surface
Membrane
Receptor Complex
Postsynapse
Molecular Function
Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity
Phospholipase C Activity
Guanyl-nucleotide Exchange Factor Activity
Neurotrophin TRKA Receptor Binding
Calcium Ion Binding
Protein Binding
Phosphoric Diester Hydrolase Activity
Hydrolase Activity
Protein Kinase Binding
Metal Ion Binding
Calcium-dependent Phospholipase C Activity
Phosphatidylinositol Phospholipase C Activity
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Hepatocyte Growth Factor Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Semaphorin Receptor Activity
Protein Phosphatase Binding
Identical Protein Binding
Molecular Function Activator Activity
Biological Process
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Lipid Metabolic Process
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Phospholipid Catabolic Process
Positive Regulation Of Epithelial Cell Migration
Lipid Catabolic Process
Cell Migration
Calcium-mediated Signaling
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Phosphatidylinositol Metabolic Process
Phosphatidylinositol-mediated Signaling
Antigen Receptor-mediated Signaling Pathway
T Cell Receptor Signaling Pathway
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Sequestering Of Calcium Ion
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Apoptotic Process
Endothelial Cell Morphogenesis
Liver Development
Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Gene Expression
Negative Regulation Of Autophagy
Neuron Differentiation
Pancreas Development
Positive Regulation Of Microtubule Polymerization
Negative Regulation Of Rho Protein Signal Transduction
Positive Regulation Of Transcription By RNA Polymerase II
Hepatocyte Growth Factor Receptor Signaling Pathway
Cell Development
Animal Organ Development
Branching Morphogenesis Of An Epithelial Tube
Positive Chemotaxis
Negative Regulation Of Stress Fiber Assembly
Excitatory Postsynaptic Potential
Establishment Of Skin Barrier
Negative Regulation Of Thrombin-activated Receptor Signaling Pathway
Semaphorin-plexin Signaling Pathway
Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity
Positive Regulation Of Endothelial Cell Chemotaxis
Pathways
ISG15 antiviral mechanism
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PLCG1 events in ERBB2 signaling
DAG and IP3 signaling
PLC-gamma1 signalling
Synthesis of IP3 and IP4 in the cytosol
Downstream signal transduction
Signaling by ALK
Generation of second messenger molecules
Role of phospholipids in phagocytosis
Role of phospholipids in phagocytosis
PECAM1 interactions
EGFR interacts with phospholipase C-gamma
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Role of second messengers in netrin-1 signaling
VEGFR2 mediated cell proliferation
VEGFR2 mediated cell proliferation
Constitutive Signaling by EGFRvIII
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
RET signaling
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PLCG1
Erythropoietin activates Phospholipase C gamma (PLCG)
Activated NTRK3 signals through PLCG1
Activated NTRK3 signals through PLCG1
FCGR3A-mediated IL10 synthesis
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by ALK fusions and activated point mutants
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Sema4D mediated inhibition of cell attachment and migration
RAF/MAP kinase cascade
MET Receptor Activation
Negative regulation of MET activity
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates RAS signaling
MET activates PI3K/AKT signaling
MET activates PTPN11
MET activates PTK2 signaling
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
MET interacts with TNS proteins
MET activates RAP1 and RAC1
MET receptor recycling
MET activates STAT3
MECP2 regulates neuronal receptors and channels
Drug-mediated inhibition of MET activation
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs
Sunitinib
K-252a
SGX-523
1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide
N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide
2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide
N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide
3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol
AMG-208
1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE
Crizotinib
Cabozantinib
Capmatinib
Tivozanib
Fostamatinib
Tivantinib
Brigatinib
Amuvatinib
Tepotinib
Amivantamab
Diseases
Cholangiocarcinoma
Gastric cancer
Renal cell carcinoma
GWAS
Apolipoprotein B levels (
32203549
)
Birth weight (
31043758
)
Brain morphology (MOSTest) (
32665545
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
LDL cholesterol levels (
32203549
)
Major depressive disorder (
27479909
)
Male-pattern baldness (
28196072
)
Refractive error (
32231278
)
Triglyceride levels (
32203549
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Age at first sexual intercourse (
34211149
)
Alanine aminotransferase levels (
33547301
)
Blood protein levels (
30072576
)
Gamma glutamyl transferase levels (
29403010
33339817
)
HDL cholesterol levels (
28334899
)
Heel bone mineral density x serum urate levels interaction (
34046847
)
Hematocrit (
28017375
)
Lung function (FEV1/FVC) (
30804560
)
Medication use (beta blocking agents) (
31015401
)
Multiple sclerosis (severity) (
19010793
)
PR segment duration (
24850809
)
Pulse pressure (
30578418
)
Resting heart rate (
27798624
29769521
)
Triglyceride levels (
28334899
)
Triglycerides (
24097068
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
112 interacting genes:
ABL1
AGAP2
AGTR1
AKT1
ALK
AR
ARHGAP32
ARHGEF5
AXL
BAG3
BCR
BLNK
BTK
CBL
CD22
CD28
CTSS
DAB1
DAPP1
DDR1
DGKZ
DNM1
DOK1
EEF1A1
EGFR
EPHB2
EPOR
ERBB2
ERBB3
ERBB4
FGFR1
FGFR2
FGFR4
FLT1
FYN
GAB1
GAB2
GHR
GIT1
GRAP
GRB2
GRIN1
GRIN2A
GRIN2B
GSN
GTF2H1
HCK
INPP5D
INSR
IRS2
ITK
KDR
KHDRBS1
KIT
LAT
LAT2
LCK
LCP2
LIFR
LYN
MAPT
MET
MST1R
NCAM1
NCK1
NPM1
NTRK1
NTRK2
NTRK3
PAK1
PDGFRA
PDGFRB
PECAM1
PICALM
PITPNA
PKN2
PLD2
PRKD1
PRMT8
PTK2
PTPN11
PTPRJ
RACK1
RBM11
RET
RHOA
RHOU
SELE
SH2D2A
SH3BP2
SHB
SHC1
SNAP91
SOCS7
SOS1
SOS2
SRC
SYK
SYN1
SYNCRIP
TEC
TNK1
TRIM14
TRPC3
TRPM7
TUB
USO1
VAV1
VAV3
VIL1
WAS
ZAP70
112 interacting genes:
ABL2
BAG1
BCAR3
BLK
BTK
CASP3
CBL
CCND2
CD44
CDK4
CDK6
CDKN2B
CNR1
CRK
CTNNB1
CTTN
DAPK3
DCN
DNAJA3
EGFR
EPHA2
ERBB2
FAS
FES
FGFR4
FGR
FZR1
GAB1
GLIS2
GLMN
GRB14
GRB2
GRB7
HCK
HGF
HGS
HSH2D
INPP5D
INPPL1
ITGB1
ITGB4
ITK
KDELR2
LATS2
LCK
LYN
MAP2K3
MAP2K5
MATK
MUC20
MYC
NCK1
NCK2
NF2
PCBD2
PIK3R1
PIK3R2
PIK3R3
PLCG1
PLCG2
PLXNB1
PTK6
PTPN11
PTPRB
PTPRJ
RAF1
RANBP10
RANBP9
RASA1
RASSF1
SH2B1
SH2B2
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3C
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SHD
SLA2
SMC1A
SNAPIN
SNX2
SOCS1
SOCS2
SOCS3
SOCS5
SOCS6
SPSB1
SRC
STAP1
STAT3
STK11
SYK
TEC
TERT
TNS1
TNS2
TNS3
TNS4
TP53
TXK
VAV1
VAV2
VAV3
YES1
ZAP70
Entrez ID
5335
4233
HPRD ID
01398
01280
Ensembl ID
ENSG00000124181
ENSG00000105976
Uniprot IDs
P19174
B4DLF5
E6Y365
P08581
PDB IDs
1HSQ
2HSP
4EY0
4FBN
7NXE
1FYR
1R0P
1R1W
1SHY
1SSL
2G15
2RFN
2RFS
2UZX
2UZY
2WD1
2WGJ
2WKM
3A4P
3BUX
3C1X
3CCN
3CD8
3CE3
3CTH
3CTJ
3DKC
3DKF
3DKG
3EFJ
3EFK
3F66
3F82
3I5N
3L8V
3LQ8
3Q6U
3Q6W
3QTI
3R7O
3RHK
3U6H
3U6I
3VW8
3ZBX
3ZC5
3ZCL
3ZXZ
3ZZE
4AOI
4AP7
4DEG
4DEH
4DEI
4EEV
4GG5
4GG7
4IWD
4K3J
4KNB
4MXC
4O3T
4O3U
4R1V
4R1Y
4XMO
4XYF
5DG5
5EOB
5EYC
5EYD
5HLW
5HNI
5HO6
5HOA
5HOR
5HTI
5LSP
5T3Q
5UAB
5UAD
5YA5
6GCU
6I04
6SD9
6SDC
6SDD
6SDE
6UBW
6WVZ
7B3Q
7B3T
7B3V
7B3W
7B3Z
7B40
7B41
7B42
7B43
7B44
7MO7
7MO8
7MO9
7MOA
7MOB
7V3R
7V3S
7Y4T
7Y4U
8AN8
8ANS
8AU3
8AU5
8AW1
8GVJ
8K78
8OUU
8OUV
8OV7
8OVZ
8OW3
8OWG
9C1R
9IVB
Enriched GO Terms of Interacting Partners
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Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Tyrosine Kinase Activity
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Peptidyl-tyrosine Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Kinase Activity
Plasma Membrane
Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Protein Phosphorylation
Phosphorylation
Regulation Of Signal Transduction
Protein Autophosphorylation
Positive Regulation Of Signal Transduction
Cell Migration
Regulation Of Signaling
Regulation Of Cell Communication
Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Immune Response-activating Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of MAPK Cascade
Immune Response-regulating Signaling Pathway
Receptor Complex
Antigen Receptor-mediated Signaling Pathway
Cell Motility
Activation Of Immune Response
Immune System Process
Intracellular Signaling Cassette
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Population Proliferation
Fc Receptor Signaling Pathway
ATP Binding
Cell Activation
Positive Regulation Of Cellular Component Organization
Regulation Of Cell Population Proliferation
Response To Growth Factor
Developmental Process
Nucleotide Binding
Leukocyte Activation
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Phosphotyrosine Residue Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Intracellular Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Cell Adhesion
Cytosol
ERBB Signaling Pathway
Immune Response-activating Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Regulation Of Immune System Process
Receptor Tyrosine Kinase Binding
Epidermal Growth Factor Receptor Signaling Pathway
Cell Activation
Peptidyl-tyrosine Phosphorylation
Leukocyte Activation
Positive Regulation Of Immune System Process
Immune Response-regulating Signaling Pathway
Negative Regulation Of Signal Transduction
Protein Kinase Activity
Lymphocyte Activation
Activation Of Immune Response
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Immune System Process
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Activation
Positive Regulation Of Immune Response
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Immune Response
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Negative Regulation Of Immune System Process
Fc Receptor Signaling Pathway
Regulation Of Lymphocyte Activation
Kinase Activity
Regulation Of Cell Population Proliferation
Regulation Of Multicellular Organismal Process
Regulation Of Cell-cell Adhesion
Regulation Of MAPK Cascade
T Cell Activation
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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