PAK1 and DSCAM

Number of citations of the paper that reports this interaction (PubMedID 15169762)
0

Data Source:
HPRD (in vivo, in vitro)

		PAK1	DSCAM
Description		p21 (RAC1) activated kinase 1	DS cell adhesion molecule
Image
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Intercalated Disc Membrane Z Disc Lamellipodium Axon Dendrite Nuclear Membrane Ruffle Membrane Protein-containing Complex Cell Projection Anchoring Junction	Extracellular Region Plasma Membrane Membrane Axon Dendrite Growth Cone Cell Projection Neuronal Cell Body Synapse
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Collagen Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Small GTPase Binding Identical Protein Binding Gamma-tubulin Binding Protein Serine Kinase Activity	Protein Binding Cell-cell Adhesion Mediator Activity Protein Tyrosine Kinase Binding Netrin Receptor Binding
	Biological Process	MAPK Cascade Response To Hypoxia Stimulatory C-type Lectin Receptor Signaling Pathway Chromatin Remodeling Exocytosis Apoptotic Process DNA Damage Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Fibroblast Migration Cell Migration Cerebellum Development Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Microtubule Polymerization Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Wound Healing Regulation Of MAPK Cascade Positive Regulation Of Axon Extension Positive Regulation Of Insulin Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Microtubule Nucleation Positive Regulation Of Protein Targeting To Membrane Regulation Of Actin Filament Organization Protein Localization To Cytoplasmic Stress Granule Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Nervous System Development Axon Guidance Synapse Assembly Central Nervous System Development Locomotory Behavior Retina Layer Formation Social Behavior Synaptic Transmission, Glutamatergic Netrin-activated Signaling Pathway Positive Regulation Of Phosphorylation Dendrite Morphogenesis Positive Regulation Of Axon Extension Involved In Axon Guidance Post-embryonic Retina Morphogenesis In Camera-type Eye Camera-type Eye Photoreceptor Cell Differentiation Dendritic Spine Development Dendrite Self-avoidance
Pathways		Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation FCERI mediated MAPK activation FCERI mediated MAPK activation CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 Signal transduction by L1 Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PKNs RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	DSCAM interactions DSCAM interactions
Drugs		Fostamatinib
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245) Tourette syndrome ( 30818990)	Adult body size ( 32376654) Anxiety in major depressive disorder ( 24047446) Blood protein levels ( 30072576) Fasting plasma glucose ( 31170924) Feeling nervous ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota relative abundance (Prevotella) ( 33208821) Hallux valgus ( 32131869) Intracranial aneurysm ( 30823506) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Mild to moderate chronic kidney disease ( 31178898) Neutrophil count ( 21507922) Non-small cell lung cancer (survival) ( 21079520) Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 34099189) Schizophrenia x sex interaction ( 34099189) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systemising ( 31508503) Tuberculosis ( 24057671) Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes		89 interacting genes: ABI3 ACTA1 ACVR1 AKT1 APP ARHGEF2 ARHGEF6 ARHGEF7 ARPC1B BAD BAIAP2 BCL6 BMPR1B BMX BRSK1 BTG3 CASP1 CDC42 CDK11B CDK5 CDK5R1 CHORDC1 COL1A1 CPLANE1 CSNK2A1 CSNK2A2 DSCAM DSCR9 DYNLL1 DYNLL2 DYRK1B EGFR ELF3 ERBB2 ESR1 FLNA FOXL2 FOXO1 FRS2 GIT2 GRB2 H3C1 H4C1 HACE1 HGS HSP90AA1 KEAP1 LIMK1 MAP2K1 MAP3K1 MAPK1 MBP MYLK MYNN MYO6 NCK1 NCK2 NF2 OXSR1 PAK1IP1 PDPK1 PLCG1 PPM1A PPM1F PPP1CA PPP2CA PRKCD PXN RAC1 RAF1 RHOJ RHOU SHC1 SMAD1 SMAD2 SMAD4 SMURF1 SORBS2 SYN1 TGFBR1 TGFBR2 TGM2 YWHAG YWHAZ ZBTB18 ZC3H7A ZNF418 ZNF823 ZNF83	157 interacting genes: ACO1 ACTN1 ACTN4 AFDN AMOTL2 AP2A1 AP2B1 APC2 ARCN1 ARIH2 ASTN1 ATP5F1B ATP6V1B2 ATRX BFSP1 BICD1 BTBD1 CADPS CAMK2A CAP2 CEP63 CFAP91 CIAO2B CIT CLTC CLU COG1 COG4 COPS5 CPNE5 CRTAC1 CSNK2B CUL9 CXXC5 DIP2A DLG1 DLG2 DLG4 DNAJA2 DPYSL2 DST DYNC1H1 DYRK1A EEF2 EIF3C ENC1 EYA3 FLNB GFAP GFPT1 GLUL GNPTAB GPRASP1 GUF1 HLA-A HNRNPF IFT122 IFT88 INTS8 IQGAP1 IST1 KALRN KCNN1 KDM4C KHDRBS1 KIF21A KIF3A KIF5A KIFC3 KLHL4 KPNB1 KRT222 KRT83 LARS1 LDB1 LIMK1 LMO2 LNX1 MACF1 MAGI2 MAGI3 MAP3K11 MAP4K4 MAT2A MERTK METAP1 METAP2 MITD1 MNAT1 MORF4L2 MPRIP MTA3 MTMR10 NAPA NAPB NCK1 NEFL NEFM NF2 NOMO2 NUP43 PAK1 PAX6 PDE4DIP PDLIM5 PIH1D2 PLEC POLDIP2 POLR3B PPP1R16B PRPF8 PSMD2 PTPN13 RAPGEF4 RCBTB1 RILPL1 ROBO1 RTL10 RUFY2 RUFY3 S100A10 SACS SDHA SEMA4D SEPTIN2 SGSM3 SHTN1 SIPA1L1 SKIL SOS2 SPTBN1 STAG1 STAT3 SUPT5H SUPV3L1 SYNE1 SYNGAP1 TARS3 TFIP11 TRIM37 TRIP11 TTC17 TTC7B UBA3 UQCRC1 USP11 VIM VPS54 WARS1 WASHC4 WDR13 WDR59 XRN2 ZBTB43 ZBTB47 ZNF202 ZNF365
Entrez ID		5058	1826
HPRD ID		03995	03953
Ensembl ID		ENSG00000149269	ENSG00000171587
Uniprot IDs		B3KNX7 E9PM17 Q13153	O60469
PDB IDs		1F3M 1YHV 1YHW 1ZSG 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC 4O0R 4O0T 4P90 4ZJI 4ZJJ 4ZLO 4ZY4 4ZY5 4ZY6 5DEW 5DEY 5DFP 5IME 5KBQ 5KBR 6B16 7VTO 8X5Z	6ZR7
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Protein Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Signal Transduction Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of Developmental Process Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Multicellular Organismal Process Response To Growth Factor Regulation Of Signal Transduction Anatomical Structure Morphogenesis Regulation Of Supramolecular Fiber Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Protein Phosphorylation ERBB Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Locomotion Focal Adhesion Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Lamellipodium Phosphorylation Regulation Of Anatomical Structure Morphogenesis Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Motility Protein Kinase Binding Regulation Of Locomotion Cytosol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cellular Component Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Cell Migration Developmental Process Regulation Of Cytoskeleton Organization Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Protein Localization	Cytoskeleton Organelle Organization Cytoplasm Cytoskeleton Organization Regulation Of Cellular Component Organization Cytosol Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis Intracellular Protein Localization Regulation Of Cell Projection Organization Cellular Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Axonogenesis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Nervous System Development Supramolecular Fiber Organization Cell Projection Actin Filament Binding Protein Binding Regulation Of Nervous System Development Positive Regulation Of Cellular Component Organization Establishment Of Localization In Cell Positive Regulation Of Neurogenesis Establishment Of Protein Localization Identical Protein Binding Positive Regulation Of Cell Projection Organization Regulation Of Neurogenesis Epithelial Cell Development Protein Transport Postsynaptic Density Retrograde Axonal Transport Intracellular Transport Microtubule-based Process Positive Regulation Of Nervous System Development Axon Cytoplasm Axonal Transport Actin Binding Cytoskeleton-dependent Intracellular Transport Intermediate Filament Developmental Process Neuron Projection Microtubule Structural Constituent Of Cytoskeleton Microtubule Cytoskeleton Organization Intermediate Filament Organization Transport Along Microtubule Axon Intermediate Filament Cytoskeleton Cadherin Binding
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