PAK1 and LIMK1

Number of citations of the paper that reports this interaction (PubMedID 11340065)
0

Data Source:
HPRD (in vitro, in vivo)

		PAK1	LIMK1
Description		p21 (RAC1) activated kinase 1	LIM domain kinase 1
Image
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Intercalated Disc Membrane Z Disc Lamellipodium Axon Dendrite Nuclear Membrane Ruffle Membrane Protein-containing Complex Cell Projection Anchoring Junction	Male Germ Cell Nucleus Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Nuclear Speck Lamellipodium Cell Junction Cell Projection Neuron Projection Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Collagen Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Small GTPase Binding Identical Protein Binding Gamma-tubulin Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Protein Serine Kinase Activity Ubiquitin Ligase Inhibitor Activity
	Biological Process	MAPK Cascade Response To Hypoxia Stimulatory C-type Lectin Receptor Signaling Pathway Chromatin Remodeling Exocytosis Apoptotic Process DNA Damage Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Fibroblast Migration Cell Migration Cerebellum Development Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Microtubule Polymerization Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Wound Healing Regulation Of MAPK Cascade Positive Regulation Of Axon Extension Positive Regulation Of Insulin Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Microtubule Nucleation Positive Regulation Of Protein Targeting To Membrane Regulation Of Actin Filament Organization Protein Localization To Cytoplasmic Stress Granule Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	Protein Phosphorylation Signal Transduction Rho Protein Signal Transduction Nervous System Development Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stress Fiber Assembly Positive Regulation Of Axon Extension Axon Extension Positive Regulation Of Stress Fiber Assembly
Pathways		Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation FCERI mediated MAPK activation FCERI mediated MAPK activation CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 Signal transduction by L1 Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PKNs RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion Sema3A PAK dependent Axon repulsion Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs RHO GTPases activate PAKs
Drugs		Fostamatinib	Dabrafenib Fostamatinib
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245) Tourette syndrome ( 30818990)	Pulse pressure ( 30224653) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		89 interacting genes: ABI3 ACTA1 ACVR1 AKT1 APP ARHGEF2 ARHGEF6 ARHGEF7 ARPC1B BAD BAIAP2 BCL6 BMPR1B BMX BRSK1 BTG3 CASP1 CDC42 CDK11B CDK5 CDK5R1 CHORDC1 COL1A1 CPLANE1 CSNK2A1 CSNK2A2 DSCAM DSCR9 DYNLL1 DYNLL2 DYRK1B EGFR ELF3 ERBB2 ESR1 FLNA FOXL2 FOXO1 FRS2 GIT2 GRB2 H3C1 H4C1 HACE1 HGS HSP90AA1 KEAP1 LIMK1 MAP2K1 MAP3K1 MAPK1 MBP MYLK MYNN MYO6 NCK1 NCK2 NF2 OXSR1 PAK1IP1 PDPK1 PLCG1 PPM1A PPM1F PPP1CA PPP2CA PRKCD PXN RAC1 RAF1 RHOJ RHOU SHC1 SMAD1 SMAD2 SMAD4 SMURF1 SORBS2 SYN1 TGFBR1 TGFBR2 TGM2 YWHAG YWHAZ ZBTB18 ZC3H7A ZNF418 ZNF823 ZNF83	31 interacting genes: ABCA1 APP ARRB1 ARRB2 BMPR2 CDC42BPA CDKN1C CFL1 CFL2 DSCAM FBXO7 H1-1 HUNK LATS1 LIMK2 MAPK14 MAPKAPK2 MBP MFHAS1 NRG1 PAK1 PAK2 PAK4 PAK6 PXN RLIM ROCK1 SRPK1 SSH3 WASHC1 YWHAZ
Entrez ID		5058	3984
HPRD ID		03995	03210
Ensembl ID		ENSG00000149269	ENSG00000106683
Uniprot IDs		B3KNX7 E9PM17 Q13153	P53667
PDB IDs		1F3M 1YHV 1YHW 1ZSG 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC 4O0R 4O0T 4P90 4ZJI 4ZJJ 4ZLO 4ZY4 4ZY5 4ZY6 5DEW 5DEY 5DFP 5IME 5KBQ 5KBR 6B16 7VTO 8X5Z	3S95 5HVJ 5HVK 5L6W 5NXC 6WLY 7ATS 7ATU 7B8W 8AAU
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Protein Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Signal Transduction Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of Developmental Process Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Multicellular Organismal Process Response To Growth Factor Regulation Of Signal Transduction Anatomical Structure Morphogenesis Regulation Of Supramolecular Fiber Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Protein Phosphorylation ERBB Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Locomotion Focal Adhesion Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Lamellipodium Phosphorylation Regulation Of Anatomical Structure Morphogenesis Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Motility Protein Kinase Binding Regulation Of Locomotion Cytosol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cellular Component Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Cell Migration Developmental Process Regulation Of Cytoskeleton Organization Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Protein Localization	Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Positive Regulation Of Cellular Component Organization Protein Kinase Activity Regulation Of Cellular Component Organization Kinase Activity Intracellular Signal Transduction Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Signal Transduction Regulation Of Actin Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Process Regulation Of Actin Filament-based Process Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling ATP Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Developmental Growth Nucleotide Binding Actin Cytoskeleton Organization Regulation Of Interleukin-6 Production Regulation Of Protein Localization To Nucleus Regulation Of Cytoskeleton Organization Actin Filament-based Process Cellular Response To Starvation Transferase Activity Regulation Of Growth Response To Growth Factor Negative Regulation Of Protein Localization To Nucleus Regulation Of Developmental Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Response To Nutrient Levels Dendritic Spine Development Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Cell Projection Organization Angiotensin Receptor Binding Protein Phosphorylation Regulation Of Receptor-mediated Endocytosis Response To Starvation Positive Regulation Of Cellular Component Biogenesis Phosphorylation Positive Regulation Of Growth Regulation Of Immune Response Regulation Of Organelle Organization Cellular Response To Nutrient Levels Regulation Of Phosphorus Metabolic Process Clathrin-coated Pit
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