PLCG1 and CD28

Number of citations of the paper that reports this interaction (PubMedID 8386518)
0

Data Source:
HPRD (in vivo)

		PLCG1	CD28
Description		phospholipase C gamma 1	CD28 molecule
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane COP9 Signalosome Lamellipodium Ruffle Membrane Cell Projection	Immunological Synapse Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Protein Complex Involved In Cell Adhesion
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Guanyl-nucleotide Exchange Factor Activity Neurotrophin TRKA Receptor Binding Calcium Ion Binding Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Protein Kinase Binding Metal Ion Binding Calcium-dependent Phospholipase C Activity Phosphatidylinositol Phospholipase C Activity	Protein Binding Coreceptor Activity Protein Kinase Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Phospholipid Catabolic Process Positive Regulation Of Epithelial Cell Migration Lipid Catabolic Process Cell Migration Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Sequestering Of Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process	Positive Regulation Of Cytokine Production Immune System Process Positive Regulation Of Inflammatory Response To Antigenic Stimulus Transcription By RNA Polymerase II Immune Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production CD4-positive, Alpha-beta T Cell Proliferation T Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Thymic T Cell Selection Regulatory T Cell Differentiation Positive Regulation Of Viral Genome Replication Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways		ISG15 antiviral mechanism Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PLCG1 events in ERBB2 signaling DAG and IP3 signaling PLC-gamma1 signalling Synthesis of IP3 and IP4 in the cytosol Downstream signal transduction Signaling by ALK Generation of second messenger molecules Role of phospholipids in phagocytosis Role of phospholipids in phagocytosis PECAM1 interactions EGFR interacts with phospholipase C-gamma DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Role of second messengers in netrin-1 signaling VEGFR2 mediated cell proliferation VEGFR2 mediated cell proliferation Constitutive Signaling by EGFRvIII Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RET signaling Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Erythropoietin activates Phospholipase C gamma (PLCG) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 FCGR3A-mediated IL10 synthesis Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by ALK fusions and activated point mutants	PIP3 activates AKT signaling Nef mediated downregulation of CD28 cell surface expression Constitutive Signaling by Aberrant PI3K in Cancer Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) LDL cholesterol levels ( 32203549) Major depressive disorder ( 27479909) Male-pattern baldness ( 28196072) Refractive error ( 32231278) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Alopecia areata ( 25608926) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 20190752 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Graves' disease ( 21841780) Heschl's gyrus morphology ( 25130324) Inflammatory bowel disease ( 26192919) Lymphocyte count ( 32888494) Multiple sclerosis ( 24076602 31604244) Primary biliary cholangitis ( 28425483) Primary sclerosing cholangitis ( 27992413 23603763) Rheumatoid arthritis ( 24390342 30423114 23143596) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 26192919)
Interacting Genes		112 interacting genes: ABL1 AGAP2 AGTR1 AKT1 ALK AR ARHGAP32 ARHGEF5 AXL BAG3 BCR BLNK BTK CBL CD22 CD28 CTSS DAB1 DAPP1 DDR1 DGKZ DNM1 DOK1 EEF1A1 EGFR EPHB2 EPOR ERBB2 ERBB3 ERBB4 FGFR1 FGFR2 FGFR4 FLT1 FYN GAB1 GAB2 GHR GIT1 GRAP GRB2 GRIN1 GRIN2A GRIN2B GSN GTF2H1 HCK INPP5D INSR IRS2 ITK KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LIFR LYN MAPT MET MST1R NCAM1 NCK1 NPM1 NTRK1 NTRK2 NTRK3 PAK1 PDGFRA PDGFRB PECAM1 PICALM PITPNA PKN2 PLD2 PRKD1 PRMT8 PTK2 PTPN11 PTPRJ RACK1 RBM11 RET RHOA RHOU SELE SH2D2A SH3BP2 SHB SHC1 SNAP91 SOCS7 SOS1 SOS2 SRC SYK SYN1 SYNCRIP TEC TNK1 TRIM14 TRPC3 TRPM7 TUB USO1 VAV1 VAV3 VIL1 WAS ZAP70	17 interacting genes: CD247 CD4 CD80 CD86 DUSP14 GRAP2 GRB2 IL12A ITK LCK LRRC23 NSF PIK3CG PIK3R1 PIK3R2 PLCG1 PTPRC
Entrez ID		5335	940
HPRD ID		01398	01727
Ensembl ID		ENSG00000124181	ENSG00000178562
Uniprot IDs		P19174	B4E0L1 P10747
PDB IDs		1HSQ 2HSP 4EY0 4FBN 7NXE	1YJD 3WA4 5AUL 5GJH 5GJI 6O8D 7PPN 7VU5 8S6Z 8W2V
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Plasma Membrane Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Phosphorylation Phosphorylation Regulation Of Signal Transduction Protein Autophosphorylation Positive Regulation Of Signal Transduction Cell Migration Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Immune Response-activating Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Receptor Complex Antigen Receptor-mediated Signaling Pathway Cell Motility Activation Of Immune Response Immune System Process Intracellular Signaling Cassette Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Population Proliferation Fc Receptor Signaling Pathway ATP Binding Cell Activation Positive Regulation Of Cellular Component Organization Regulation Of Cell Population Proliferation Response To Growth Factor Developmental Process Nucleotide Binding Leukocyte Activation Regulation Of Immune Response Positive Regulation Of Immune System Process	T Cell Activation Lymphocyte Activation Cell Activation Leukocyte Activation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway T Cell Differentiation Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Cell Adhesion Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Mononuclear Cell Differentiation B Cell Receptor Signaling Pathway Gamma-delta T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Leukocyte Differentiation Regulation Of Leukocyte Cell-cell Adhesion Lymphocyte Differentiation Regulation Of T Cell Activation Neurotrophin TRKA Receptor Binding Positive Regulation Of T Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Interleukin-2 Production Phosphatidylinositol 3-kinase Complex, Class IA Alpha-beta T Cell Activation Immune Response Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cytokine Production Regulation Of Lymphocyte Activation T Cell Costimulation Immune Response-activating Signaling Pathway Regulation Of Immune System Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Multicellular Organismal Process Regulation Of Mononuclear Cell Proliferation Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Hemopoiesis Positive Regulation Of Metabolic Process Regulation Of Interleukin-2 Production Regulation Of Leukocyte Proliferation Intracellular Signal Transduction
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