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PAK1 and RHOJ
Number of citations of the paper that reports this interaction (PMID
10967094
)
19
Data Source:
HPRD
(two hybrid, in vitro)
PAK1
RHOJ
Gene Name
p21 protein (Cdc42/Rac)-activated kinase 1
ras homolog family member J
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Ruffle
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Intercalated Disc
Z Disc
Axon
Dendrite
Growth Cone
Filamentous Actin
Nuclear Membrane
Ruffle Membrane
Protein Complex
Cytosol
Plasma Membrane
Extracellular Vesicular Exosome
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Receptor Signaling Protein Serine/threonine Kinase Activity
Protein Binding
Collagen Binding
ATP Binding
Protein Kinase Binding
GTPase Activity
GTP Binding
Biological Process
MAPK Cascade
Mitotic Cell Cycle
Response To Hypoxia
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Exocytosis
Apoptotic Process
Axon Guidance
Neuromuscular Junction Development
Dendrite Development
Signal Transduction By Phosphorylation
T Cell Costimulation
Actin Cytoskeleton Reorganization
Cellular Response To Insulin Stimulus
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Wound Healing
Receptor Clustering
Positive Regulation Of JUN Kinase Activity
Innate Immune Response
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Branching Morphogenesis Of An Epithelial Tube
Neuron Projection Morphogenesis
T Cell Receptor Signaling Pathway
Positive Regulation Of Stress Fiber Assembly
Negative Regulation Of Cell Proliferation Involved In Contact Inhibition
Small GTPase Mediated Signal Transduction
Rho Protein Signal Transduction
Metabolic Process
Regulation Of Cell Shape
Actin Cytoskeleton Organization
Regulation Of Small GTPase Mediated Signal Transduction
Retina Vasculature Morphogenesis In Camera-type Eye
Pathways
Axon guidance
Costimulation by the CD28 family
FCERI mediated MAPK activation
L1CAM interactions
VEGFA-VEGFR2 Pathway
EPHB-mediated forward signaling
Ephrin signaling
Activation of Rac
VEGFR2 mediated vascular permeability
EPH-Ephrin signaling
Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation
Innate Immune System
Generation of second messenger molecules
Signal transduction by L1
Semaphorin interactions
CD28 co-stimulation
CD28 dependent Vav1 pathway
TCR signaling
DSCAM interactions
Signaling by VEGF
Sema3A PAK dependent Axon repulsion
Fc epsilon receptor (FCERI) signaling
Signaling by Robo receptor
Adaptive Immune System
Rho GTPase cycle
Signaling by Rho GTPases
Drugs
Diseases
GWAS
Protein-Protein Interactions
83 interactors:
ABI3
ACTA1
ACVR1
AKT1
APP
ARHGEF2
ARHGEF6
ARHGEF7
ARPC1B
BAD
BAIAP2
BMPR1B
BMX
BRSK1
C5orf42
CASP1
CDC42
CDK11B
CDK5
CDK5R1
CHORDC1
COL1A1
CRIPAK
CSNK2A1
CSNK2A2
DSCAM
DYNLL1
DYNLL2
DYRK1B
EGFR
ELF3
ERBB2
ESR1
FLNA
FOXL2
FOXO1
FRS2
GIT2
GRB2
HGS
HIST1H3A
HIST1H4A
HSP90AA1
LIMK1
MAP2K1
MAP3K1
MAPK1
MBP
MYLK
MYNN
MYO6
NCK1
NCK2
NF2
OXSR1
PAK1IP1
PDPK1
PLCG1
PPM1F
PRKCD
PXN
RAC1
RAF1
RHOJ
RHOU
SHC1
SMAD1
SMAD2
SMAD4
SMURF1
SORBS2
SORBS3
SYN1
TGFBR1
TGFBR2
TGM2
YWHAG
YWHAZ
ZBTB18
ZC3H7A
ZNF418
ZNF823
ZNF83
21 interactors:
ACVR1
ADAMTSL4
BHLHE40
BLZF1
BMPR1B
CDC42
CDC42EP1
DOCK10
DOCK8
MEOX2
PAK1
PAK2
PAK6
PARD6B
SMAD2
SMAD4
SSX3
TGFBR1
TRIP10
WAS
WASL
Entrez ID
5058
57381
HPRD ID
03995
09632
Ensembl ID
ENSG00000149269
ENSG00000126785
Uniprot IDs
B3KNX7
Q13153
Q7Z513
Q9H4E5
PDB IDs
1F3M
1YHV
1YHW
1ZSG
2HY8
2QME
3DVP
3FXZ
3FY0
3Q4Z
3Q52
3Q53
4DAW
4EQC
Enriched GO Terms of Interacting Partners
?
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Signaling
Regulation Of Signal Transduction
Anatomical Structure Morphogenesis
Regulation Of Cellular Component Organization
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of Phosphorylation
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Cell Differentiation
Cell Development
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Fc Receptor Signaling Pathway
Cell Morphogenesis Involved In Differentiation
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Signal Transduction
Anatomical Structure Development
System Development
Regulation Of Kinase Activity
Intracellular Signal Transduction
Developmental Process
Regulation Of Protein Phosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Cellular Process
Regulation Of Organelle Organization
Neurotrophin Signaling Pathway
Regulation Of Protein Kinase Activity
Multicellular Organismal Development
Neurogenesis
Axon Guidance
Regulation Of Protein Metabolic Process
Cell Morphogenesis Involved In Neuron Differentiation
Generation Of Neurons
Axonogenesis
Cell Communication
Cell Projection Organization
Tissue Development
Cell Morphogenesis
Positive Regulation Of Cellular Metabolic Process
Regulation Of Intracellular Signal Transduction
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Signaling
Neuron Projection Morphogenesis
Axon Development
Regulation Of Metabolic Process
Positive Regulation Of Protein Metabolic Process
Defense Response
Intracellular Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Cell Morphogenesis Involved In Differentiation
Signal Transduction By Phosphorylation
Movement Of Cell Or Subcellular Component
Axonogenesis
Axon Development
Regulation Of Metabolic Process
Cell Morphogenesis Involved In Neuron Differentiation
Locomotion
Regulation Of Cellular Process
Axon Guidance
Neuron Projection Morphogenesis
Cell Development
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Anatomical Structure Morphogenesis
Cell Morphogenesis
Activin Receptor Signaling Pathway
Signal Transduction
Palate Development
Pattern Specification Process
Neuron Differentiation
Regulation Of Cell Projection Assembly
Fc Receptor Signaling Pathway
Neuron Projection Development
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cell Fate Commitment
Signaling
Cell Projection Morphogenesis
Transforming Growth Factor Beta Receptor Signaling Pathway
Cell Part Morphogenesis
Regulation Of Signal Transduction
Cell Communication
Positive Regulation Of Cellular Component Biogenesis
Positive Regulation Of Signal Transduction
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Tissue Development
Regulation Of Nitrogen Compound Metabolic Process
Chemotaxis
Regulation Of Filopodium Assembly
Peptidyl-threonine Phosphorylation
Endocardial Cell Differentiation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc-gamma Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Neuron Development
Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Cellular Response To Transforming Growth Factor Beta Stimulus
Tagcloud
?
advance
belonging
cdc2
cdc42
coordinate
coordinates
coordinating
cot1
delays
dystrophy
encodes
fission
genetically
interphase
maintain
maintains
mitosis
mitotic
morphogenesis
myotonic
orb2
orb6
p34
polarity
polarized
ras1
shape
shk1
threonine
Tagcloud (Difference)
?
advance
belonging
cdc2
cdc42
coordinate
coordinates
coordinating
cot1
delays
dystrophy
encodes
fission
genetically
interphase
maintain
maintains
mitosis
mitotic
morphogenesis
myotonic
orb2
orb6
p34
polarity
polarized
ras1
shape
shk1
threonine
Tagcloud (Intersection)
?