HIF1A and ISG15

Number of citations of the paper that reports this interaction (PubMedID 24056783)
0

Data Source:
BioGRID (pull down)

		HIF1A	ISG15
Description		hypoxia inducible factor 1 subunit alpha	ISG15 ubiquitin like modifier
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Nuclear Body Nuclear Speck Motile Cilium Protein-containing Complex RNA Polymerase II Transcription Regulator Complex Axon Cytoplasm	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Repressor Activity Transcription Corepressor Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Nuclear Receptor Binding Enzyme Binding Protein Kinase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity Hsp90 Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Transcription Regulator Activator Activity	Integrin Binding Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding
	Biological Process	Response To Reactive Oxygen Species Angiogenesis Blood Vessel Development Response To Hypoxia Intracellular Glucose Homeostasis Neural Crest Cell Migration Epithelial To Mesenchymal Transition Embryonic Placenta Development B-1 B Cell Homeostasis Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Heart Looping Positive Regulation Of Neuroblast Proliferation Chondrocyte Differentiation Glandular Epithelial Cell Differentiation Glandular Epithelial Cell Maturation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Outflow Tract Morphogenesis Cardiac Ventricle Morphogenesis Lactate Metabolic Process Regulation Of Glycolytic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Apoptotic Process Signal Transduction Neuroblast Proliferation Lactation Visual Learning Response To Iron Ion Regulation Of Gene Expression Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Response To Muscle Activity Positive Regulation Of Macroautophagy Axonal Transport Of Mitochondrion Neural Fold Elevation Formation Cerebral Cortex Development Cell Differentiation Negative Regulation Of Ossification Bone Mineralization Negative Regulation Of Bone Mineralization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway TOR Signaling Negative Regulation Of TOR Signaling Intracellular Oxygen Homeostasis Positive Regulation Of Chemokine Production Regulation Of Transforming Growth Factor Beta2 Production Collagen Metabolic Process Cellular Response To Oxidative Stress Embryonic Hemopoiesis Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Cell Population Proliferation Hemoglobin Biosynthetic Process Glucose Homeostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Growth Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Positive Regulation Of Hormone Biosynthetic Process Blood Vessel Morphogenesis Digestive Tract Morphogenesis Camera-type Eye Morphogenesis Cartilage Development Neuron Apoptotic Process Elastin Metabolic Process Intestinal Epithelial Cell Maturation Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Iris Morphogenesis Retina Vasculature Development In Camera-type Eye Positive Regulation Of Chemokine-mediated Signaling Pathway Regulation Of Thymocyte Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Cellular Response To Interleukin-1 Cellular Response To Hypoxia Dopaminergic Neuron Differentiation Mesenchymal Cell Apoptotic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Cellular Response To Virus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Protein Neddylation Negative Regulation Of Mesenchymal Cell Apoptotic Process	Immune System Process Regulation Of Immune System Process Integrin-mediated Signaling Pathway Response To Virus Response To Bacterium Protein Ubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Bone Mineralization Negative Regulation Of Protein Ubiquitination ISG15-protein Conjugation Positive Regulation Of Protein Oligomerization Regulation Of Type II Interferon Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Response To Type I Interferon Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Multicellular Organismal Process Defense Response To Virus Negative Regulation Of Type I Interferon-mediated Signaling Pathway Protein Localization To Mitochondrion
Pathways		Regulation of gene expression by Hypoxia-inducible Factor Cellular response to hypoxia Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha NOTCH1 Intracellular Domain Regulates Transcription Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling PTK6 Expression PTK6 promotes HIF1A stabilization Neddylation STAT3 nuclear events downstream of ALK signaling Regulation of PD-L1(CD274) transcription	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Interferon alpha/beta signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes
Drugs		Carvedilol Hydralazine 2-Methoxyestradiol ENMD-1198 PX-478 FG-2216 Vadadustat
Diseases
GWAS			Blood protein levels ( 30072576)
Interacting Genes		133 interacting genes: AKT1 APEX1 AR ARNT ARNT2 ATM AURKA BAP1 BMAL1 BNIP3 CASR CCND2 CDC34 CDK4 CDK6 CDKN2A CDKN2B CHD4 CITED2 COPS5 CREB3L1 CREBBP CSNK1D CSNK2A1 CTNNB1 DAP3 E2F7 EAF2 EGLN1 EGLN2 EGLN3 EIF5A2 EP300 EPHA2 EPO ESRRA ESRRB ESRRG ETV4 F12 FBXL16 FBXO8 FGFR4 FZR1 GATA3 GLIS2 HDAC1 HDAC2 HDAC3 HDAC5 HIF1A-AS2 HIF1AN HIF3A HNF4A HSP90AA1 IKBKG ISG15 JUN KPNA1 KPNA3 KPNA4 KPNA5 KPNA6 L3MBTL3 LATS2 LINC01139 LRRK2 MAFG MAFK MAP2K3 MAP2K5 MAPK1 MAPK3 MAX MCL1 MCM7 MDM2 MTA1 MYC NAA10 NAA11 NBN NCOA1 NCOA2 NDN NEDD8 NF2 NQO1 NR4A1 OS9 PER1 PGK1 PKM PLD1 PLD2 PLK3 PPP1R13L PRKACA PSMA7 PTBP1 PTK6 RACGAP1 RACK1 RB1 RORA RUNX2 RWDD3 SAT1 SEPTIN9 SIRT2 SMAD3 SNHG11 SP1 SSX4 STAT3 STK11 SUCO SUMO1 TEAD2 TP53 TSGA10 UBE2D1 UBE2I UBE3B USP19 USP20 USP28 VBP1 VEGFA VHL VHLL VRK1 ZC3H12A	25 interacting genes: BRAP CBX5 DDOST FUS GRPEL1 HDAC6 HIF1A KLHL26 MRTO4 NAP1L1 NCL PFN1 RPL23 RPL3 RPN2 SUMO1 TPM3 TPM4 TUBA1B UBA7 USP14 USP16 USP18 USP21 USP5
Entrez ID		3091	9636
HPRD ID		04517	00958
Ensembl ID		ENSG00000100644	ENSG00000187608
Uniprot IDs		D0VY79 Q16665	P05161
PDB IDs		1H2K 1H2L 1H2M 1L3E 1L8C 1LM8 1LQB 2ILM 3HQR 3HQU 4AJY 4H6J 5JWP 5L9B 5L9V 5LA9 5LAS 6GFX 6GMR 6YW3 7LVS 7QGS 8HE0 8HE3	1Z2M 2HJ8 3PHX 3PSE 3R66 3RT3 3SDL 5TL6 5W8T 5W8U 6BI8 6FFA 6XA9 7RBS 7S6P 8OIF 8SE9 8SEA 8SEB 8SV8
Enriched GO Terms of Interacting Partners?		Nucleoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Metabolic Process Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process DNA-binding Transcription Factor Binding Regulation Of Intracellular Signal Transduction Chromatin Regulation Of Developmental Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Response To Oxygen Levels Response To Stress Response To Decreased Oxygen Levels Regulation Of Cell Cycle Response To Hypoxia Regulation Of Signaling Regulation Of Cell Communication Protein Modification Process	Cysteine-type Deubiquitinase Activity Protein Deubiquitination Regulation Of Protein Stability Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Presynaptic Cytosol Muscle Thin Filament Tropomyosin Oligosaccharyltransferase Complex B Macromolecule Metabolic Process Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Oligosaccharyltransferase Complex A Cytoplasm Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Cysteine-type Endopeptidase Activity Regulation Of Epithelial Cell Migration Oligosaccharyltransferase Complex Negative Regulation Of Catabolic Process Axonal Transport Of Mitochondrion Adenyl-nucleotide Exchange Factor Activity Regulation Of Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Nucleolus Peptidase Activity Ubiquitin Binding Cellular Response To Interleukin-4 Deubiquitinase Activity Protein K48-linked Deubiquitination Mitochondrion Transport Along Microtubule Response To Interleukin-4 Postsynaptic Cytosol Histone Deacetylase Binding Response To Cytokine RNA Binding Regulation Of Protein Metabolic Process Establishment Of Mitochondrion Localization Response To Peptide Proteolysis Positive Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process ISG15 Activating Enzyme Activity Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Ribosome Biogenesis Hsp90 Protein Binding
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