HIF1A and CITED2

Number of citations of the paper that reports this interaction (PMID 12778114)
38

Data Source:
HPRD (in vitro)

		HIF1A	CITED2
Gene Name		hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Cytosol Motile Cilium RNA Polymerase II Transcription Factor Complex	Nuclear Chromatin Nucleus Cytoplasm
	Molecular Function	Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Transcription Factor Binding Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Acetyltransferase Binding Nuclear Hormone Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Hsp90 Protein Binding	RNA Polymerase II Transcription Corepressor Activity Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Histone Acetyltransferase Binding LBD Domain Binding
	Biological Process	Angiogenesis Response To Hypoxia Neural Crest Cell Migration Epithelial To Mesenchymal Transition Embryonic Placenta Development B-1 B Cell Homeostasis Positive Regulation Of Endothelial Cell Proliferation Heart Looping Positive Regulation Of Neuroblast Proliferation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Outflow Tract Morphogenesis Cardiac Ventricle Morphogenesis Lactate Metabolic Process Regulation Of Transcription, DNA-templated Cellular Iron Ion Homeostasis Signal Transduction Notch Signaling Pathway Lactation Visual Learning Regulation Of Gene Expression Vascular Endothelial Growth Factor Production Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Receptor Biosynthetic Process Response To Muscle Activity Axon Transport Of Mitochondrion Neural Fold Elevation Formation Cerebral Cortex Development Negative Regulation Of Bone Mineralization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Oxygen Homeostasis Positive Regulation Of Chemokine Production Regulation Of Transforming Growth Factor Beta2 Production Collagen Metabolic Process Embryonic Hemopoiesis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Hemoglobin Biosynthetic Process Glucose Homeostasis MRNA Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter Muscle Cell Cellular Homeostasis Positive Regulation Of Hormone Biosynthetic Process Digestive Tract Morphogenesis Positive Regulation Of Nitric-oxide Synthase Activity Cartilage Development Elastin Metabolic Process Intestinal Epithelial Cell Maturation Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Retina Vasculature Development In Camera-type Eye Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Thymocyte Apoptotic Process Cellular Response To Interleukin-1 Cellular Response To Hypoxia Dopaminergic Neuron Differentiation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Mesenchymal Cell Apoptotic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Liver Development Outflow Tract Morphogenesis Regulation Of Organ Formation Transcription, DNA-templated Determination Of Left/right Symmetry Heart Development Sex Determination Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Fluid Shear Stress Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Adrenal Cortex Formation Negative Regulation Of Apoptotic Process Response To Estrogen Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Ventricular Septum Morphogenesis Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Left/right Axis Specification Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Male Gonad Development
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Signaling by NOTCH Regulation of gene expression by Hypoxia-inducible Factor Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS			Blood trace element (Se levels) ( 23720494) HDL cholesterol ( 20686565) Mean corpuscular hemoglobin ( 23263863 20139978 19862010) Mean corpuscular volume ( 23263863 20139978 19862010) Obesity-related traits ( 23251661) Red blood cell traits ( 23222517)
Protein-Protein Interactions		67 interactors: APEX1 AR ARNT ARNT2 ARNTL ATM CDC34 CDKN2A CITED2 COPS5 CREBBP CSNK2A1 CTNNB1 DAP3 EGLN1 EGLN2 EGLN3 EP300 FHL2 GNB2L1 HDAC1 HDAC2 HDAC5 HIF1AN HIF3A HSP90AA1 HSP90AB1 JUN MAFG MAFK MAPK1 MAPK3 MAX MCM7 MDM2 MTA1 NAA10 NAA11 NCOA1 NCOA2 NDN NR4A1 OS9 PER1 PGK1 PKM PLD1 PSMA7 RB1 RUNX2 RWDD3 SAT1 SEPT9 SP1 SSX4 STAT3 STUB1 SUMO1 SUMO2 TP53 TRAF6 TSGA10 UBE2D1 USP19 USP20 VHL VHLL	10 interactors: CREBBP EP300 HIF1A LHX2 LHX3 TBP TFAP2A TFAP2B TFAP2C UBC
Entrez ID		3091	10370
HPRD ID		04517	04245
Ensembl ID		ENSG00000100644	ENSG00000164442
Uniprot IDs		A8MYV6 D0VY79 Q16665	D9ZGF1 Q99967
PDB IDs		1D7G 1H2K 1H2L 1H2M 1L3E 1L8C 1LM8 1LQB 2ILM 3HQR 3HQU 4AJY 4H6J	1P4Q 1R8U
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Stress Cellular Metabolic Process Cellular Response To Hypoxia Regulation Of RNA Metabolic Process Cellular Response To Decreased Oxygen Levels Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Oxygen Levels Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Stimulus Nucleobase-containing Compound Metabolic Process Response To Abiotic Stimulus Biosynthetic Process Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Response To Hypoxia Cellular Aromatic Compound Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Gene Expression Response To Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of Protein Metabolic Process Response To Growth Factor	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Tube Development RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Metabolic Process Gene Expression Regulation Of DNA-templated Transcription In Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Hypoxia Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cellular Response To Decreased Oxygen Levels Nucleobase-containing Compound Metabolic Process Cellular Response To Oxygen Levels Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Notch Signaling Pathway N-terminal Peptidyl-lysine Acetylation Anatomical Structure Morphogenesis Retina Development In Camera-type Eye Nitrogen Compound Metabolic Process Forebrain Development Pattern Specification Process Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Epithelium Development Germ-line Stem Cell Maintenance
Tagcloud ?		actual ahr analytic atf4 becomes datasets hepato lists mechanistically mining modulation nephro nrf2 omic ppar precision promise publicly seq signatures tcx tf tfs thorough toxicological toxins tracked transcriptomics xbp1	1ss adamts5 aggrecan articular ccr2 chondroprotective conclusionsthis destabilization disintegrin dmm drg egcg frey gallate introductionepigallocatechin mark13 mark3 mark8 meniscus methodsc57bl oa oarsi osteoarthritis relieve resultsfour safranin slows thrombospondin transactivator traveled
Tagcloud (Difference) ?		actual ahr analytic atf4 becomes datasets hepato lists mechanistically mining modulation nephro nrf2 omic ppar precision promise publicly seq signatures tcx tf tfs thorough toxicological toxins tracked transcriptomics xbp1	1ss adamts5 aggrecan articular ccr2 chondroprotective conclusionsthis destabilization disintegrin dmm drg egcg frey gallate introductionepigallocatechin mark13 mark3 mark8 meniscus methodsc57bl oa oarsi osteoarthritis relieve resultsfour safranin slows thrombospondin transactivator traveled
Tagcloud (Intersection) ?