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HIF1A and HDAC2
Number of citations of the paper that reports this interaction (PubMedID
11641274
)
44
Data Source:
BioGRID
(imaging technique, pull down)
HIF1A
HDAC2
Description
hypoxia inducible factor 1 subunit alpha
histone deacetylase 2
Image
GO Annotations
Cellular Component
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Nuclear Body
Nuclear Speck
Motile Cilium
Protein-containing Complex
RNA Polymerase II Transcription Regulator Complex
Axon Cytoplasm
Histone Deacetylase Complex
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
NuRD Complex
Protein-containing Complex
ESC/E(Z) Complex
Sin3-type Complex
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity
DNA-binding Transcription Repressor Activity
Transcription Corepressor Binding
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Nuclear Receptor Binding
Enzyme Binding
Protein Kinase Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Protein Dimerization Activity
Hsp90 Protein Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
E-box Binding
Transcription Regulator Activator Activity
Transcription Coregulator Binding
Chromatin Binding
RNA Binding
Histone Deacetylase Activity
Protein Binding
Hydrolase Activity
Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides
Deacetylase Activity
Enzyme Binding
Heat Shock Protein Binding
Nucleosomal DNA Binding
Protein Lysine Deacetylase Activity
Histone Binding
Histone Deacetylase Binding
NF-kappaB Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA-binding Transcription Factor Binding
Histone Deacetylase Activity, Hydrolytic Mechanism
Protein Decrotonylase Activity
Histone Decrotonylase Activity
Protein De-2-hydroxyisobutyrylase Activity
Protein Lysine Delactylase Activity
Promoter-specific Chromatin Binding
Biological Process
Response To Reactive Oxygen Species
Angiogenesis
Blood Vessel Development
Response To Hypoxia
Intracellular Glucose Homeostasis
Neural Crest Cell Migration
Epithelial To Mesenchymal Transition
Embryonic Placenta Development
B-1 B Cell Homeostasis
Positive Regulation Of Endothelial Cell Proliferation
Vasculature Development
Heart Looping
Positive Regulation Of Neuroblast Proliferation
Chondrocyte Differentiation
Glandular Epithelial Cell Differentiation
Glandular Epithelial Cell Maturation
Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Outflow Tract Morphogenesis
Cardiac Ventricle Morphogenesis
Lactate Metabolic Process
Regulation Of Glycolytic Process
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Intracellular Iron Ion Homeostasis
Apoptotic Process
Signal Transduction
Neuroblast Proliferation
Lactation
Visual Learning
Response To Iron Ion
Regulation Of Gene Expression
Vascular Endothelial Growth Factor Production
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Response To Muscle Activity
Positive Regulation Of Macroautophagy
Axonal Transport Of Mitochondrion
Neural Fold Elevation Formation
Cerebral Cortex Development
Cell Differentiation
Negative Regulation Of Ossification
Bone Mineralization
Negative Regulation Of Bone Mineralization
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
TOR Signaling
Negative Regulation Of TOR Signaling
Intracellular Oxygen Homeostasis
Positive Regulation Of Chemokine Production
Regulation Of Transforming Growth Factor Beta2 Production
Collagen Metabolic Process
Cellular Response To Oxidative Stress
Embryonic Hemopoiesis
Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Regulation Of Cell Population Proliferation
Hemoglobin Biosynthetic Process
Glucose Homeostasis
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Glycolytic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Growth
Positive Regulation Of Transcription By RNA Polymerase II
Muscle Cell Cellular Homeostasis
Positive Regulation Of Hormone Biosynthetic Process
Blood Vessel Morphogenesis
Digestive Tract Morphogenesis
Camera-type Eye Morphogenesis
Cartilage Development
Neuron Apoptotic Process
Elastin Metabolic Process
Intestinal Epithelial Cell Maturation
Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development
Iris Morphogenesis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of Chemokine-mediated Signaling Pathway
Regulation Of Thymocyte Apoptotic Process
Negative Regulation Of Thymocyte Apoptotic Process
Cellular Response To Interleukin-1
Cellular Response To Hypoxia
Dopaminergic Neuron Differentiation
Mesenchymal Cell Apoptotic Process
Hypoxia-inducible Factor-1alpha Signaling Pathway
Cellular Response To Virus
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of MiRNA Transcription
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Nitric Oxide Metabolic Process
Regulation Of Protein Neddylation
Negative Regulation Of Mesenchymal Cell Apoptotic Process
Negative Regulation Of Transcription By RNA Polymerase II
Response To Amphetamine
Cardiac Muscle Hypertrophy
Chromatin Organization
Chromatin Remodeling
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Epidermal Cell Differentiation
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Transcription By Competitive Promoter Binding
Negative Regulation Of Neuron Projection Development
Dendrite Development
Negative Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Caffeine
Heterochromatin Formation
Response To Lipopolysaccharide
Positive Regulation Of Interleukin-1 Production
Positive Regulation Of Tumor Necrosis Factor Production
Circadian Regulation Of Gene Expression
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Cellular Response To Heat
Response To Nicotine
Protein Modification Process
Response To Cocaine
Odontogenesis Of Dentin-containing Tooth
Regulation Of Cell Fate Specification
Embryonic Digit Morphogenesis
Negative Regulation Of Apoptotic Process
Positive Regulation Of Proteolysis
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Behavioral Response To Ethanol
Rhythmic Process
Positive Regulation Of Oligodendrocyte Differentiation
Progesterone Receptor Signaling Pathway
Response To Hyperoxia
Hair Follicle Placode Formation
Negative Regulation Of Dendritic Spine Development
Eyelid Development In Camera-type Eye
Fungiform Papilla Formation
Cellular Response To Hydrogen Peroxide
Cellular Response To Retinoic Acid
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Alcohol
Positive Regulation Of Male Mating Behavior
Negative Regulation Of Stem Cell Population Maintenance
Positive Regulation Of Stem Cell Population Maintenance
Cellular Response To Dopamine
Response To Amyloid-beta
Regulation Of Stem Cell Differentiation
Pathways
Regulation of gene expression by Hypoxia-inducible Factor
Cellular response to hypoxia
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
NOTCH1 Intracellular Domain Regulates Transcription
Ub-specific processing proteases
Interleukin-4 and Interleukin-13 signaling
PTK6 Expression
PTK6 promotes HIF1A stabilization
Neddylation
STAT3 nuclear events downstream of ALK signaling
Regulation of PD-L1(CD274) transcription
p75NTR negatively regulates cell cycle via SC1
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
SUMOylation of chromatin organization proteins
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
EGR2 and SOX10-mediated initiation of Schwann cell myelination
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Potential therapeutics for SARS
STAT3 nuclear events downstream of ALK signaling
Negative Regulation of CDH1 Gene Transcription
Factors involved in megakaryocyte development and platelet production
Regulation of endogenous retroelements by KRAB-ZFP proteins
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Carvedilol
Hydralazine
2-Methoxyestradiol
ENMD-1198
PX-478
FG-2216
Vadadustat
Pravastatin
Lovastatin
Theophylline
Valproic acid
Valproic acid
Simvastatin
Atorvastatin
Fluvastatin
Aminophylline
Decitabine
Oxtriphylline
Vorinostat
Vorinostat
Belinostat
Pracinostat
Romidepsin
Romidepsin
Panobinostat
Phenylbutyric acid
Tixocortol
Mocetinostat
Entinostat
Abexinostat
Givinostat
Pyroxamide
Diseases
GWAS
Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy (
26460308
)
Metabolite levels (
23823483
)
Interacting Genes
133 interacting genes:
AKT1
APEX1
AR
ARNT
ARNT2
ATM
AURKA
BAP1
BMAL1
BNIP3
CASR
CCND2
CDC34
CDK4
CDK6
CDKN2A
CDKN2B
CHD4
CITED2
COPS5
CREB3L1
CREBBP
CSNK1D
CSNK2A1
CTNNB1
DAP3
E2F7
EAF2
EGLN1
EGLN2
EGLN3
EIF5A2
EP300
EPHA2
EPO
ESRRA
ESRRB
ESRRG
ETV4
F12
FBXL16
FBXO8
FGFR4
FZR1
GATA3
GLIS2
HDAC1
HDAC2
HDAC3
HDAC5
HIF1A-AS2
HIF1AN
HIF3A
HNF4A
HSP90AA1
IKBKG
ISG15
JUN
KPNA1
KPNA3
KPNA4
KPNA5
KPNA6
L3MBTL3
LATS2
LINC01139
LRRK2
MAFG
MAFK
MAP2K3
MAP2K5
MAPK1
MAPK3
MAX
MCL1
MCM7
MDM2
MTA1
MYC
NAA10
NAA11
NBN
NCOA1
NCOA2
NDN
NEDD8
NF2
NQO1
NR4A1
OS9
PER1
PGK1
PKM
PLD1
PLD2
PLK3
PPP1R13L
PRKACA
PSMA7
PTBP1
PTK6
RACGAP1
RACK1
RB1
RORA
RUNX2
RWDD3
SAT1
SEPTIN9
SIRT2
SMAD3
SNHG11
SP1
SSX4
STAT3
STK11
SUCO
SUMO1
TEAD2
TP53
TSGA10
UBE2D1
UBE2I
UBE3B
USP19
USP20
USP28
VBP1
VEGFA
VHL
VHLL
VRK1
ZC3H12A
97 interacting genes:
ANTXR1
APPL1
ARID4A
AURKA
BRCA1
BRMS1
BRMS1L
BUB3
CDC20
CDH1
CDKN1A
CDYL
CEBPA
CHFR
CIRSR
CSNK2A1
CSNK2A2
CTBP1
CUL4B
CYTOR
DAXX
DDX20
DMAP1
DNMT1
DNMT3B
EED
EID2
ERCC6
FKBP3
GATA3
H2AC1
H2AC20
H2BC21
H3-4
H3C1
HDAC1
HDAC10
HDAC7
HIF1A
HIF1AN
HOPX
IFRD1
IKZF1
IKZF4
ING1
JUP
MAD1L1
MBD2
MTA1
MXD1
NACC2
NRIP1
PA2G4
PADI4
PHB2
PHF21A
PIAS4
PML
PPARD
PPP1R8
PTMA
RBBP4
RBBP7
RBP1
RCOR1
RELA
RFX5
RUNX3
SALL1
SAP30
SETDB1
SIN3A
SMAD2
SMARCA5
SMYD1
SNW1
SP1
SP3
SPEN
SS18L1
STAT3
SUMO2
SUV39H1
SYK
TFCP2
THRA
THRB
TMEM132D
TOP2A
TOP2B
TP53
UBC
USP4
VHL
YY1
ZBTB16
ZNF461
Entrez ID
3091
3066
HPRD ID
04517
05521
Ensembl ID
ENSG00000100644
ENSG00000196591
Uniprot IDs
D0VY79
Q16665
Q92769
PDB IDs
1H2K
1H2L
1H2M
1L3E
1L8C
1LM8
1LQB
2ILM
3HQR
3HQU
4AJY
4H6J
5JWP
5L9B
5L9V
5LA9
5LAS
6GFX
6GMR
6YW3
7LVS
7QGS
8HE0
8HE3
3MAX
4LXZ
4LY1
5IWG
5IX0
6G3O
6WBW
6WBZ
6WHN
6WHO
6WHQ
6WHZ
6WI3
6XDM
6XEB
6XEC
7JS8
7KBG
7KBH
7LTG
7LTK
7LTL
7MOS
7MOT
7MOX
7MOY
7MOZ
7ZZO
7ZZP
7ZZR
7ZZS
7ZZT
7ZZU
7ZZW
8A0B
8BPA
8BPB
8BPC
8C60
9DTQ
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Stress
Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Negative Regulation Of Metabolic Process
Intracellular Signal Transduction
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Signal Transduction
Positive Regulation Of Protein Metabolic Process
DNA-binding Transcription Factor Binding
Regulation Of Intracellular Signal Transduction
Chromatin
Regulation Of Developmental Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Response To Oxygen Levels
Response To Stress
Response To Decreased Oxygen Levels
Regulation Of Cell Cycle
Response To Hypoxia
Regulation Of Signaling
Regulation Of Cell Communication
Protein Modification Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Nucleus
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin Organization
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Metabolic Process
Nucleoplasm
Regulation Of Primary Metabolic Process
Regulation Of Metabolic Process
Chromatin Remodeling
DNA Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Transcription Corepressor Activity
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Sin3-type Complex
Histone Deacetylase Binding
Chromatin Binding
Positive Regulation Of Metabolic Process
Regulation Of Developmental Process
Positive Regulation Of Macromolecule Biosynthetic Process
Histone Deacetylase Complex
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Developmental Process
Negative Regulation Of Stem Cell Population Maintenance
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Epigenetic Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Transcription Repressor Complex
Negative Regulation Of Developmental Process
Negative Regulation Of Gene Expression, Epigenetic
Heterochromatin Formation
Protein-containing Complex
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Cell Differentiation
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Tagcloud (Intersection)
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