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HIF1A and L3MBTL3
Number of citations of the paper that reports this interaction (PubMedID
36747531
)
33
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, pull down)
HIF1A
L3MBTL3
Description
hypoxia inducible factor 1 subunit alpha
L3MBTL histone methyl-lysine binding protein 3
Image
GO Annotations
Cellular Component
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Nuclear Body
Nuclear Speck
Motile Cilium
Protein-containing Complex
RNA Polymerase II Transcription Regulator Complex
Axon Cytoplasm
Nucleus
Nucleoplasm
Nucleolus
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity
DNA-binding Transcription Repressor Activity
Transcription Corepressor Binding
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Nuclear Receptor Binding
Enzyme Binding
Protein Kinase Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Protein Dimerization Activity
Hsp90 Protein Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
E-box Binding
Transcription Regulator Activator Activity
Chromatin Binding
Protein Binding
Zinc Ion Binding
Histone Binding
Identical Protein Binding
Metal Ion Binding
Methylation-dependent Protein Binding
Biological Process
Response To Reactive Oxygen Species
Angiogenesis
Blood Vessel Development
Response To Hypoxia
Intracellular Glucose Homeostasis
Neural Crest Cell Migration
Epithelial To Mesenchymal Transition
Embryonic Placenta Development
B-1 B Cell Homeostasis
Positive Regulation Of Endothelial Cell Proliferation
Vasculature Development
Heart Looping
Positive Regulation Of Neuroblast Proliferation
Chondrocyte Differentiation
Glandular Epithelial Cell Differentiation
Glandular Epithelial Cell Maturation
Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Outflow Tract Morphogenesis
Cardiac Ventricle Morphogenesis
Lactate Metabolic Process
Regulation Of Glycolytic Process
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Intracellular Iron Ion Homeostasis
Apoptotic Process
Signal Transduction
Neuroblast Proliferation
Lactation
Visual Learning
Response To Iron Ion
Regulation Of Gene Expression
Vascular Endothelial Growth Factor Production
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Response To Muscle Activity
Positive Regulation Of Macroautophagy
Axonal Transport Of Mitochondrion
Neural Fold Elevation Formation
Cerebral Cortex Development
Cell Differentiation
Negative Regulation Of Ossification
Bone Mineralization
Negative Regulation Of Bone Mineralization
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
TOR Signaling
Negative Regulation Of TOR Signaling
Intracellular Oxygen Homeostasis
Positive Regulation Of Chemokine Production
Regulation Of Transforming Growth Factor Beta2 Production
Collagen Metabolic Process
Cellular Response To Oxidative Stress
Embryonic Hemopoiesis
Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Regulation Of Cell Population Proliferation
Hemoglobin Biosynthetic Process
Glucose Homeostasis
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Glycolytic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Growth
Positive Regulation Of Transcription By RNA Polymerase II
Muscle Cell Cellular Homeostasis
Positive Regulation Of Hormone Biosynthetic Process
Blood Vessel Morphogenesis
Digestive Tract Morphogenesis
Camera-type Eye Morphogenesis
Cartilage Development
Neuron Apoptotic Process
Elastin Metabolic Process
Intestinal Epithelial Cell Maturation
Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development
Iris Morphogenesis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of Chemokine-mediated Signaling Pathway
Regulation Of Thymocyte Apoptotic Process
Negative Regulation Of Thymocyte Apoptotic Process
Cellular Response To Interleukin-1
Cellular Response To Hypoxia
Dopaminergic Neuron Differentiation
Mesenchymal Cell Apoptotic Process
Hypoxia-inducible Factor-1alpha Signaling Pathway
Cellular Response To Virus
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of MiRNA Transcription
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Nitric Oxide Metabolic Process
Regulation Of Protein Neddylation
Negative Regulation Of Mesenchymal Cell Apoptotic Process
Chromatin Organization
Regulation Of DNA-templated Transcription
Myeloid Cell Differentiation
Macrophage Differentiation
Granulocyte Differentiation
Erythrocyte Maturation
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Regulation of gene expression by Hypoxia-inducible Factor
Cellular response to hypoxia
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
NOTCH1 Intracellular Domain Regulates Transcription
Ub-specific processing proteases
Interleukin-4 and Interleukin-13 signaling
PTK6 Expression
PTK6 promotes HIF1A stabilization
Neddylation
STAT3 nuclear events downstream of ALK signaling
Regulation of PD-L1(CD274) transcription
Drugs
Carvedilol
Hydralazine
2-Methoxyestradiol
ENMD-1198
PX-478
FG-2216
Vadadustat
Diseases
GWAS
A body shape index (
34021172
)
Alanine aminotransferase levels (
34315874
33547301
)
Apolipoprotein B levels (
32203549
)
Appendicular lean mass (
33097823
)
Aspartate aminotransferase levels (
34315874
33547301
)
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Birth weight (
27680694
31043758
)
Body mass index (
25673413
)
Breast cancer (
29058716
29059683
)
Breast cancer (estrogen-receptor negative) (
29058716
)
C-reactive protein levels (
30388399
)
Chronic kidney disease (
31152163
)
Estimated glomerular filtration rate (
31152163
)
Heel bone mineral density (
30598549
28869591
)
Height (
20881960
31562340
18391951
23563607
25282103
28552196
25429064
)
Hematocrit (
27863252
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
32327693
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Hip circumference (
25673412
)
Hip circumference adjusted for BMI (
34021172
25673412
28552196
)
Immature fraction of reticulocytes (
32888494
)
Influenza A (H1N1) infection (
26379185
)
LDL cholesterol levels (
32203549
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Low density lipoprotein cholesterol levels (
32154731
)
Lymphocyte count (
32888494
27863252
)
Mild influenza (H1N1) infection (
26379185
)
Multiple sclerosis (
31604244
27386562
)
Offspring birth weight (
31043758
)
Red blood cell count (
32888494
)
Reticulocyte count (
32888494
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Spleen volume (
34128465
)
Triglyceride levels (
32203549
32154731
)
Triglyceride levels in HIV infection (
33109212
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Weight (
28552196
)
White blood cell count (
32888494
)
Interacting Genes
133 interacting genes:
AKT1
APEX1
AR
ARNT
ARNT2
ATM
AURKA
BAP1
BMAL1
BNIP3
CASR
CCND2
CDC34
CDK4
CDK6
CDKN2A
CDKN2B
CHD4
CITED2
COPS5
CREB3L1
CREBBP
CSNK1D
CSNK2A1
CTNNB1
DAP3
E2F7
EAF2
EGLN1
EGLN2
EGLN3
EIF5A2
EP300
EPHA2
EPO
ESRRA
ESRRB
ESRRG
ETV4
F12
FBXL16
FBXO8
FGFR4
FZR1
GATA3
GLIS2
HDAC1
HDAC2
HDAC3
HDAC5
HIF1A-AS2
HIF1AN
HIF3A
HNF4A
HSP90AA1
IKBKG
ISG15
JUN
KPNA1
KPNA3
KPNA4
KPNA5
KPNA6
L3MBTL3
LATS2
LINC01139
LRRK2
MAFG
MAFK
MAP2K3
MAP2K5
MAPK1
MAPK3
MAX
MCL1
MCM7
MDM2
MTA1
MYC
NAA10
NAA11
NBN
NCOA1
NCOA2
NDN
NEDD8
NF2
NQO1
NR4A1
OS9
PER1
PGK1
PKM
PLD1
PLD2
PLK3
PPP1R13L
PRKACA
PSMA7
PTBP1
PTK6
RACGAP1
RACK1
RB1
RORA
RUNX2
RWDD3
SAT1
SEPTIN9
SIRT2
SMAD3
SNHG11
SP1
SSX4
STAT3
STK11
SUCO
SUMO1
TEAD2
TP53
TSGA10
UBE2D1
UBE2I
UBE3B
USP19
USP20
USP28
VBP1
VEGFA
VHL
VHLL
VRK1
ZC3H12A
58 interacting genes:
ASB6
BANP
BYSL
C1QTNF4
CRLF3
DEF6
DNMT1
DRC4
FLAD1
FNDC3B
FXR2
H3C1
HIF1A
HSF2BP
IL16
KANK2
KDM1A
LIG1
LMO4
LRRK2
LSM4
LZTR1
MAPK3
MAPK9
MFAP1
MORF4L1
MORF4L2
NGB
NRF1
NTAQ1
OAZ3
PDE6G
PHC2
PHF21A
PIK3R3
PLEKHF1
PLEKHF2
PLOD3
POLR2L
PPP2CA
PRKAA1
PRKAA2
RHOBTB3
SFMBT2
SNRPB
SOX2
SP100
SPANXN2
SUFU
SUMO1P1
TBC1D1
TCEANC
THRA
TRAF3IP3
TSTD2
TTC19
ZCWPW1
ZNF76
Entrez ID
3091
84456
HPRD ID
04517
11222
Ensembl ID
ENSG00000100644
ENSG00000198945
Uniprot IDs
D0VY79
Q16665
Q96JM7
PDB IDs
1H2K
1H2L
1H2M
1L3E
1L8C
1LM8
1LQB
2ILM
3HQR
3HQU
4AJY
4H6J
5JWP
5L9B
5L9V
5LA9
5LAS
6GFX
6GMR
6YW3
7LVS
7QGS
8HE0
8HE3
1WJQ
1WJS
3UT1
4FL6
4L59
7RTE
7RTI
8Y76
8Y77
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Stress
Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Negative Regulation Of Metabolic Process
Intracellular Signal Transduction
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Signal Transduction
Positive Regulation Of Protein Metabolic Process
DNA-binding Transcription Factor Binding
Regulation Of Intracellular Signal Transduction
Chromatin
Regulation Of Developmental Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Response To Oxygen Levels
Response To Stress
Response To Decreased Oxygen Levels
Regulation Of Cell Cycle
Response To Hypoxia
Regulation Of Signaling
Regulation Of Cell Communication
Protein Modification Process
Protein Binding
Nucleus
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Nucleoplasm
Regulation Of Macromolecule Metabolic Process
Histone H2BS36 Kinase Activity
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
Nuclear Speck
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Glycolytic Process
Positive Regulation Of Autophagy
Positive Regulation Of Metabolic Process
Positive Regulation Of Glycolytic Process
Protein Localization To Lipid Droplet
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Carbohydrate Catabolic Process
Chromatin Organization
Positive Regulation Of Catabolic Process
Regulation Of ATP Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Tubulin Deacetylation
Negative Regulation Of Hepatocyte Apoptotic Process
AMP-activated Protein Kinase Activity
Regulation Of Purine Nucleotide Metabolic Process
Chromatin Binding
TOR Signaling
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Tubulin Deacetylation
Lipid Droplet Disassembly
Negative Regulation Of TOR Signaling
Macromolecule Biosynthetic Process
Positive Regulation Of ATP Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of DNA-templated Transcription
Negative Regulation Of Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Macromolecule Metabolic Process
Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Regulation Of Neuroblast Proliferation
Regulation Of Primary Metabolic Process
Negative Regulation Of Metabolic Process
Phosphatidylethanolamine Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
DNA-templated Transcription
Cellular Response To Stress
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Tagcloud (Intersection)
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