HIF1A and CASR

Number of citations of the paper that reports this interaction (PubMedID 21316481)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		HIF1A	CASR
Description		hypoxia inducible factor 1 subunit alpha	calcium sensing receptor
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Nuclear Body Nuclear Speck Motile Cilium Protein-containing Complex RNA Polymerase II Transcription Regulator Complex Axon Cytoplasm	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Axon Presynaptic Membrane Neuronal Cell Body Axon Terminus Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Repressor Activity Transcription Corepressor Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Nuclear Receptor Binding Enzyme Binding Protein Kinase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity Hsp90 Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Transcription Regulator Activator Activity	G Protein-coupled Receptor Activity Integrin Binding Calcium Ion Binding Protein Binding Amino Acid Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Response To Reactive Oxygen Species Angiogenesis Blood Vessel Development Response To Hypoxia Intracellular Glucose Homeostasis Neural Crest Cell Migration Epithelial To Mesenchymal Transition Embryonic Placenta Development B-1 B Cell Homeostasis Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Heart Looping Positive Regulation Of Neuroblast Proliferation Chondrocyte Differentiation Glandular Epithelial Cell Differentiation Glandular Epithelial Cell Maturation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Outflow Tract Morphogenesis Cardiac Ventricle Morphogenesis Lactate Metabolic Process Regulation Of Glycolytic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Apoptotic Process Signal Transduction Neuroblast Proliferation Lactation Visual Learning Response To Iron Ion Regulation Of Gene Expression Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Response To Muscle Activity Positive Regulation Of Macroautophagy Axonal Transport Of Mitochondrion Neural Fold Elevation Formation Cerebral Cortex Development Cell Differentiation Negative Regulation Of Ossification Bone Mineralization Negative Regulation Of Bone Mineralization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway TOR Signaling Negative Regulation Of TOR Signaling Intracellular Oxygen Homeostasis Positive Regulation Of Chemokine Production Regulation Of Transforming Growth Factor Beta2 Production Collagen Metabolic Process Cellular Response To Oxidative Stress Embryonic Hemopoiesis Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Cell Population Proliferation Hemoglobin Biosynthetic Process Glucose Homeostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Growth Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Positive Regulation Of Hormone Biosynthetic Process Blood Vessel Morphogenesis Digestive Tract Morphogenesis Camera-type Eye Morphogenesis Cartilage Development Neuron Apoptotic Process Elastin Metabolic Process Intestinal Epithelial Cell Maturation Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Iris Morphogenesis Retina Vasculature Development In Camera-type Eye Positive Regulation Of Chemokine-mediated Signaling Pathway Regulation Of Thymocyte Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Cellular Response To Interleukin-1 Cellular Response To Hypoxia Dopaminergic Neuron Differentiation Mesenchymal Cell Apoptotic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Cellular Response To Virus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Protein Neddylation Negative Regulation Of Mesenchymal Cell Apoptotic Process	Ossification Response To Ischemia Detection Of Calcium Ion Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway JNK Cascade Chemosensory Behavior Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Response To Metal Ion Positive Regulation Of Gene Expression Positive Regulation Of Insulin Secretion Bile Acid Secretion Cellular Response To Hepatocyte Growth Factor Stimulus Vasodilation Positive Regulation Of Vasoconstriction Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Positive Chemotaxis Response To Calcium Ion Regulation Of Calcium Ion Transport Fat Pad Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Vitamin D Cellular Response To Glucose Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Hypoxia Response To Fibroblast Growth Factor Positive Regulation Of Calcium Ion Import Regulation Of Presynaptic Membrane Potential Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Positive Regulation Of NLRP3 Inflammasome Complex Assembly Cellular Response To Peptide Chloride Transmembrane Transport
Pathways		Regulation of gene expression by Hypoxia-inducible Factor Cellular response to hypoxia Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha NOTCH1 Intracellular Domain Regulates Transcription Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling PTK6 Expression PTK6 promotes HIF1A stabilization Neddylation STAT3 nuclear events downstream of ALK signaling Regulation of PD-L1(CD274) transcription	G alpha (q) signalling events G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		Carvedilol Hydralazine 2-Methoxyestradiol ENMD-1198 PX-478 FG-2216 Vadadustat	Spermine Neomycin Cinacalcet Ronacaleret NPS-2143 Calcium citrate Calcium Phosphate Etelcalcetide Calcium phosphate dihydrate
Diseases			Bartter syndrome
GWAS			Calcium levels ( 20661308 20705733 24068962 29403010 25886283 25972035) Cardiac Troponin-T levels ( 23247143) Chronic widespread musculoskeletal pain ( 33331911) Clinical laboratory measurements ( 27897004) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Kidney stones ( 26272126) Metabolite levels ( 31628463) Phosphorus levels ( 20558539) Psoriasis ( 25854761) QT interval ( 29874175) Serum parathyroid hormone levels ( 27927781) Type 2 diabetes ( 30718926 32499647)
Interacting Genes		133 interacting genes: AKT1 APEX1 AR ARNT ARNT2 ATM AURKA BAP1 BMAL1 BNIP3 CASR CCND2 CDC34 CDK4 CDK6 CDKN2A CDKN2B CHD4 CITED2 COPS5 CREB3L1 CREBBP CSNK1D CSNK2A1 CTNNB1 DAP3 E2F7 EAF2 EGLN1 EGLN2 EGLN3 EIF5A2 EP300 EPHA2 EPO ESRRA ESRRB ESRRG ETV4 F12 FBXL16 FBXO8 FGFR4 FZR1 GATA3 GLIS2 HDAC1 HDAC2 HDAC3 HDAC5 HIF1A-AS2 HIF1AN HIF3A HNF4A HSP90AA1 IKBKG ISG15 JUN KPNA1 KPNA3 KPNA4 KPNA5 KPNA6 L3MBTL3 LATS2 LINC01139 LRRK2 MAFG MAFK MAP2K3 MAP2K5 MAPK1 MAPK3 MAX MCL1 MCM7 MDM2 MTA1 MYC NAA10 NAA11 NBN NCOA1 NCOA2 NDN NEDD8 NF2 NQO1 NR4A1 OS9 PER1 PGK1 PKM PLD1 PLD2 PLK3 PPP1R13L PRKACA PSMA7 PTBP1 PTK6 RACGAP1 RACK1 RB1 RORA RUNX2 RWDD3 SAT1 SEPTIN9 SIRT2 SMAD3 SNHG11 SP1 SSX4 STAT3 STK11 SUCO SUMO1 TEAD2 TP53 TSGA10 UBE2D1 UBE2I UBE3B USP19 USP20 USP28 VBP1 VEGFA VHL VHLL VRK1 ZC3H12A	11 interacting genes: FLNA GRM1 HIF1A NOTCH1 PI4K2B PRKCA PRKCB PRKCG RNF19A STAMBP VHL
Entrez ID		3091	846
HPRD ID		04517	03122
Ensembl ID		ENSG00000100644	ENSG00000036828
Uniprot IDs		D0VY79 Q16665	P41180
PDB IDs		1H2K 1H2L 1H2M 1L3E 1L8C 1LM8 1LQB 2ILM 3HQR 3HQU 4AJY 4H6J 5JWP 5L9B 5L9V 5LA9 5LAS 6GFX 6GMR 6YW3 7LVS 7QGS 8HE0 8HE3	5FBH 5FBK 5K5S 5K5T 7DTT 7DTU 7DTV 7DTW 7E6T 7E6U 7M3E 7M3F 7M3G 7M3J 7SIL 7SIM 7SIN 8SZF 8SZG 8SZH 8SZI 8WPG 8WPU 9ASB 9AVG 9AVL 9AXF 9AYF 9C1P 9C2F 9J7I
Enriched GO Terms of Interacting Partners?		Nucleoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Metabolic Process Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process DNA-binding Transcription Factor Binding Regulation Of Intracellular Signal Transduction Chromatin Regulation Of Developmental Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Response To Oxygen Levels Response To Stress Response To Decreased Oxygen Levels Regulation Of Cell Cycle Response To Hypoxia Regulation Of Signaling Regulation Of Cell Communication Protein Modification Process	Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Histone H3T6 Kinase Activity Negative Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Secretion By Cell Regulation Of Secretion Protein Kinase C Signaling Positive Regulation Of Neural Precursor Cell Proliferation Regulation Of Exocytosis Regulation Of Protein Transport Regulation Of Cell Communication Regulation Of Signaling Synaptic Signaling Via Neuropeptide Regulation Of Apoptotic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Transport Transcription Regulator Activator Activity Mitotic Nuclear Membrane Disassembly Regulation Of Programmed Cell Death Positive Regulation Of Insulin Secretion Regulation Of Protein Secretion Regulation Of Neural Precursor Cell Proliferation Regulation Of Signal Transduction Regulation Of Transport Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Membrane Disassembly Nuclear Membrane Disassembly Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Peptide Hormone Secretion Regulation Of Cell Population Proliferation Positive Regulation Of Peptide Secretion Regulation Of Blood Vessel Endothelial Cell Migration Calyx Of Held Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Regulated Secretory Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Response To Hypoxia Glandular Epithelial Cell Differentiation Cellular Response To Decreased Oxygen Levels Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Enzyme Binding Plasma Membrane Positive Regulation Of Neuroblast Proliferation Negative Regulation Of Biomineral Tissue Development Presynaptic Cytosol Cellular Response To Oxygen Levels
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