HIF1A and HIF1AN

Number of citations of the paper that reports this interaction (PMID 11641274)
198

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		HIF1A	HIF1AN
Gene Name		hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	hypoxia inducible factor 1, alpha subunit inhibitor
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Cytosol Motile Cilium RNA Polymerase II Transcription Factor Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Transcription Factor Binding Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Acetyltransferase Binding Nuclear Hormone Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Hsp90 Protein Binding	Notch Binding Iron Ion Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Oxygen Sensor Activity Carboxylic Acid Binding Peptidyl-histidine Dioxygenase Activity Peptidyl-asparagine 3-dioxygenase Activity Protein Homodimerization Activity Cofactor Binding NF-kappaB Binding Ankyrin Repeat Binding
	Biological Process	Angiogenesis Response To Hypoxia Neural Crest Cell Migration Epithelial To Mesenchymal Transition Embryonic Placenta Development B-1 B Cell Homeostasis Positive Regulation Of Endothelial Cell Proliferation Heart Looping Positive Regulation Of Neuroblast Proliferation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Outflow Tract Morphogenesis Cardiac Ventricle Morphogenesis Lactate Metabolic Process Regulation Of Transcription, DNA-templated Cellular Iron Ion Homeostasis Signal Transduction Notch Signaling Pathway Lactation Visual Learning Regulation Of Gene Expression Vascular Endothelial Growth Factor Production Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Receptor Biosynthetic Process Response To Muscle Activity Axon Transport Of Mitochondrion Neural Fold Elevation Formation Cerebral Cortex Development Negative Regulation Of Bone Mineralization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Oxygen Homeostasis Positive Regulation Of Chemokine Production Regulation Of Transforming Growth Factor Beta2 Production Collagen Metabolic Process Embryonic Hemopoiesis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Hemoglobin Biosynthetic Process Glucose Homeostasis MRNA Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter Muscle Cell Cellular Homeostasis Positive Regulation Of Hormone Biosynthetic Process Digestive Tract Morphogenesis Positive Regulation Of Nitric-oxide Synthase Activity Cartilage Development Elastin Metabolic Process Intestinal Epithelial Cell Maturation Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Retina Vasculature Development In Camera-type Eye Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Thymocyte Apoptotic Process Cellular Response To Interleukin-1 Cellular Response To Hypoxia Dopaminergic Neuron Differentiation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Mesenchymal Cell Apoptotic Process	Transcription, DNA-templated Peptidyl-histidine Hydroxylation Peptidyl-aspartic Acid Hydroxylation Peptidyl-asparagine Hydroxylation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Notch Signaling Pathway Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Positive Regulation Of Vasculogenesis
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Signaling by NOTCH Regulation of gene expression by Hypoxia-inducible Factor Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer	Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha
Drugs
Diseases
GWAS			Palmitoleic acid (16:1n-7) plasma levels ( 23362303)
Protein-Protein Interactions		67 interactors: APEX1 AR ARNT ARNT2 ARNTL ATM CDC34 CDKN2A CITED2 COPS5 CREBBP CSNK2A1 CTNNB1 DAP3 EGLN1 EGLN2 EGLN3 EP300 FHL2 GNB2L1 HDAC1 HDAC2 HDAC5 HIF1AN HIF3A HSP90AA1 HSP90AB1 JUN MAFG MAFK MAPK1 MAPK3 MAX MCM7 MDM2 MTA1 NAA10 NAA11 NCOA1 NCOA2 NDN NR4A1 OS9 PER1 PGK1 PKM PLD1 PSMA7 RB1 RUNX2 RWDD3 SAT1 SEPT9 SP1 SSX4 STAT3 STUB1 SUMO1 SUMO2 TP53 TRAF6 TSGA10 UBE2D1 USP19 USP20 VHL VHLL	13 interactors: ASB13 ASB4 ASB9 FBF1 FEM1B HDAC1 HDAC2 HDAC3 HIF1A INVS NFKB1 UACA VHL
Entrez ID		3091	55662
HPRD ID		04517	09426
Ensembl ID		ENSG00000100644
Uniprot IDs		A8MYV6 D0VY79 Q16665	Q9NWT6
PDB IDs		1D7G 1H2K 1H2L 1H2M 1L3E 1L8C 1LM8 1LQB 2ILM 3HQR 3HQU 4AJY 4H6J	1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Stress Cellular Metabolic Process Cellular Response To Hypoxia Regulation Of RNA Metabolic Process Cellular Response To Decreased Oxygen Levels Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Oxygen Levels Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Stimulus Nucleobase-containing Compound Metabolic Process Response To Abiotic Stimulus Biosynthetic Process Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Response To Hypoxia Cellular Aromatic Compound Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Gene Expression Response To Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of Protein Metabolic Process Response To Growth Factor	Positive Regulation Of Receptor Biosynthetic Process Regulation Of Receptor Biosynthetic Process Histone H4 Deacetylation Regulation Of Apoptotic Process Regulation Of Cell Death Histone H3 Deacetylation Histone H3-K9 Modification Histone Deacetylation Negative Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Protein Deacetylation Negative Regulation Of Programmed Cell Death Neurotrophin Signaling Pathway Negative Regulation Of Cell Death Fungiform Papilla Formation Circadian Regulation Of Gene Expression Protein Ubiquitination Fungiform Papilla Morphogenesis Negative Regulation Of Signal Transduction Protein Modification By Small Protein Conjugation Fungiform Papilla Development Eyelid Development In Camera-type Eye Negative Regulation Of Signaling Hair Follicle Placode Formation Regulation Of Signal Transduction Tongue Morphogenesis Cellular Response To Stimulus Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Epithelial Cell Maturation Notch Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Cell Differentiation Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Protein Modification Process Signaling Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cell Communication Circadian Rhythm Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Tongue Development Epithelial Cell Differentiation Positive Regulation Of Cellular Metabolic Process Epithelium Development
Tagcloud ?		actual ahr analytic atf4 becomes datasets hepato lists mechanistically mining modulation nephro nrf2 omic ppar precision promise publicly seq signatures tcx tf tfs thorough toxicological toxins tracked transcriptomics xbp1	bomb coimmunoprecipitation collated cytoskeleton defines depicts dissect evolutionarily fate fih interacted interesting mib mib2 mind notch protease ran screens summarized trabid traf ubiquitin ubiquitylate ubiquitylation usp1 usp9 zebrafish zranb1
Tagcloud (Difference) ?		actual ahr analytic atf4 becomes datasets hepato lists mechanistically mining modulation nephro nrf2 omic ppar precision promise publicly seq signatures tcx tf tfs thorough toxicological toxins tracked transcriptomics xbp1	bomb coimmunoprecipitation collated cytoskeleton defines depicts dissect evolutionarily fate fih interacted interesting mib mib2 mind notch protease ran screens summarized trabid traf ubiquitin ubiquitylate ubiquitylation usp1 usp9 zebrafish zranb1
Tagcloud (Intersection) ?