HIF1A and CCND2

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		HIF1A	CCND2
Description		hypoxia inducible factor 1 subunit alpha	cyclin D2
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Nuclear Body Nuclear Speck Motile Cilium Protein-containing Complex RNA Polymerase II Transcription Regulator Complex Axon Cytoplasm	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Organizing Center Cytosol Membrane Nuclear Membrane Cyclin D2-CDK4 Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Repressor Activity Transcription Corepressor Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Nuclear Receptor Binding Enzyme Binding Protein Kinase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Protein Dimerization Activity Hsp90 Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Transcription Regulator Activator Activity	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Response To Reactive Oxygen Species Angiogenesis Blood Vessel Development Response To Hypoxia Intracellular Glucose Homeostasis Neural Crest Cell Migration Epithelial To Mesenchymal Transition Embryonic Placenta Development B-1 B Cell Homeostasis Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Heart Looping Positive Regulation Of Neuroblast Proliferation Chondrocyte Differentiation Glandular Epithelial Cell Differentiation Glandular Epithelial Cell Maturation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Outflow Tract Morphogenesis Cardiac Ventricle Morphogenesis Lactate Metabolic Process Regulation Of Glycolytic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Apoptotic Process Signal Transduction Neuroblast Proliferation Lactation Visual Learning Response To Iron Ion Regulation Of Gene Expression Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Response To Muscle Activity Positive Regulation Of Macroautophagy Axonal Transport Of Mitochondrion Neural Fold Elevation Formation Cerebral Cortex Development Cell Differentiation Negative Regulation Of Ossification Bone Mineralization Negative Regulation Of Bone Mineralization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway TOR Signaling Negative Regulation Of TOR Signaling Intracellular Oxygen Homeostasis Positive Regulation Of Chemokine Production Regulation Of Transforming Growth Factor Beta2 Production Collagen Metabolic Process Cellular Response To Oxidative Stress Embryonic Hemopoiesis Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Cell Population Proliferation Hemoglobin Biosynthetic Process Glucose Homeostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Glycolytic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Growth Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Positive Regulation Of Hormone Biosynthetic Process Blood Vessel Morphogenesis Digestive Tract Morphogenesis Camera-type Eye Morphogenesis Cartilage Development Neuron Apoptotic Process Elastin Metabolic Process Intestinal Epithelial Cell Maturation Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Iris Morphogenesis Retina Vasculature Development In Camera-type Eye Positive Regulation Of Chemokine-mediated Signaling Pathway Regulation Of Thymocyte Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Cellular Response To Interleukin-1 Cellular Response To Hypoxia Dopaminergic Neuron Differentiation Mesenchymal Cell Apoptotic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Cellular Response To Virus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Protein Neddylation Negative Regulation Of Mesenchymal Cell Apoptotic Process	G1/S Transition Of Mitotic Cell Cycle Long-term Memory Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Negative Regulation Of Apoptotic Process Cell Division Regulation Of Cell Cycle Cellular Response To X-ray Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Regulation of gene expression by Hypoxia-inducible Factor Cellular response to hypoxia Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha NOTCH1 Intracellular Domain Regulates Transcription Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling PTK6 Expression PTK6 promotes HIF1A stabilization Neddylation STAT3 nuclear events downstream of ALK signaling Regulation of PD-L1(CD274) transcription	Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Drug-mediated inhibition of CDK4/CDK6 activity
Drugs		Carvedilol Hydralazine 2-Methoxyestradiol ENMD-1198 PX-478 FG-2216 Vadadustat
Diseases			Testicular cancer
GWAS			Alanine aminotransferase levels ( 34315874) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 34315874) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Blood glucose levels ( 31928498) Brown vs. black hair color ( 30531825) Colorectal cancer ( 24836286 31826910 26151821 30529582 23266556 23263487) Colorectal cancer or advanced adenoma ( 30510241) Glucocorticoid-induced osteonecrosis ( 26265699) Height ( 28270201 28552196) Low density lipoprotein cholesterol levels ( 32154731) Major depressive disorder ( 19107115 23377640) Mean corpuscular hemoglobin ( 28017375) Mean corpuscular volume ( 28017375) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 27841878 30578418) QT interval (drug interaction) ( 23459443) Red blood cell count ( 20139978 28017375) Red blood cell traits ( 23222517) Smoking behaviour (cigarettes smoked per day) ( 30679032) Triglyceride levels ( 31928498 32154731 32203549) Type 2 diabetes ( 30297969 31118516 30054458 29358691 28869590 32499647 22885922) Waist circumference ( 31928498)
Interacting Genes		133 interacting genes: AKT1 APEX1 AR ARNT ARNT2 ATM AURKA BAP1 BMAL1 BNIP3 CASR CCND2 CDC34 CDK4 CDK6 CDKN2A CDKN2B CHD4 CITED2 COPS5 CREB3L1 CREBBP CSNK1D CSNK2A1 CTNNB1 DAP3 E2F7 EAF2 EGLN1 EGLN2 EGLN3 EIF5A2 EP300 EPHA2 EPO ESRRA ESRRB ESRRG ETV4 F12 FBXL16 FBXO8 FGFR4 FZR1 GATA3 GLIS2 HDAC1 HDAC2 HDAC3 HDAC5 HIF1A-AS2 HIF1AN HIF3A HNF4A HSP90AA1 IKBKG ISG15 JUN KPNA1 KPNA3 KPNA4 KPNA5 KPNA6 L3MBTL3 LATS2 LINC01139 LRRK2 MAFG MAFK MAP2K3 MAP2K5 MAPK1 MAPK3 MAX MCL1 MCM7 MDM2 MTA1 MYC NAA10 NAA11 NBN NCOA1 NCOA2 NDN NEDD8 NF2 NQO1 NR4A1 OS9 PER1 PGK1 PKM PLD1 PLD2 PLK3 PPP1R13L PRKACA PSMA7 PTBP1 PTK6 RACGAP1 RACK1 RB1 RORA RUNX2 RWDD3 SAT1 SEPTIN9 SIRT2 SMAD3 SNHG11 SP1 SSX4 STAT3 STK11 SUCO SUMO1 TEAD2 TP53 TSGA10 UBE2D1 UBE2I UBE3B USP19 USP20 USP28 VBP1 VEGFA VHL VHLL VRK1 ZC3H12A	64 interacting genes: ABCB5 ABL1 ADRB2 AKAP8 AKT1 ARAF ARNT AURKA BECN1 CALM1 CALM2 CALM3 CBLC CCNE1 CD44 CDK4 CDK5 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C DMTF1 EPHA2 ERBB2 FBXL2 FGFR4 FZR1 GLIS2 GRM1 H1-1 HGF HIF1A KAT2A KDELR2 LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MET NF2 NPDC1 PCGF2 PDGFRA PIK3CA PSMD10 PTEN RAF1 RASSF1 RB1 RELA RUNX1 SERTAD1 STK11 TEAD2 TERT TEX11 TNFRSF1A TSC1 TTYH2
Entrez ID		3091	894
HPRD ID		04517	00451
Ensembl ID		ENSG00000100644	ENSG00000118971
Uniprot IDs		D0VY79 Q16665	P30279
PDB IDs		1H2K 1H2L 1H2M 1L3E 1L8C 1LM8 1LQB 2ILM 3HQR 3HQU 4AJY 4H6J 5JWP 5L9B 5L9V 5LA9 5LAS 6GFX 6GMR 6YW3 7LVS 7QGS 8HE0 8HE3	6EI2
Enriched GO Terms of Interacting Partners?		Nucleoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Metabolic Process Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process DNA-binding Transcription Factor Binding Regulation Of Intracellular Signal Transduction Chromatin Regulation Of Developmental Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Response To Oxygen Levels Response To Stress Response To Decreased Oxygen Levels Regulation Of Cell Cycle Response To Hypoxia Regulation Of Signaling Regulation Of Cell Communication Protein Modification Process	Regulation Of Cell Cycle Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Animal Organ Development Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Signal Transduction Protein Kinase Activity Regulation Of Cell Cycle Process Regulation Of Cell Population Proliferation Intracellular Signal Transduction Regulation Of Cell Cycle Phase Transition Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Intracellular Signaling Cassette Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Kinase Binding Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Developmental Process Positive Regulation Of Signal Transduction Protein Serine Kinase Activity Regulation Of Growth Regulation Of Apoptotic Process Cell Cycle Phase Transition Negative Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Cellular Senescence Regulation Of Catalytic Activity Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Developmental Process Apoptotic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Programmed Cell Death Cell Death Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Metabolic Process Regulation Of Cell Differentiation Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Cell Differentiation
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