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EGLN3 and MAPK7
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
EGLN3
MAPK7
Gene Name
egl-9 family hypoxia-inducible factor 3
mitogen-activated protein kinase 7
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
PML Body
Molecular Function
Iron Ion Binding
Protein Binding
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors
L-ascorbic Acid Binding
Peptidyl-proline 4-dioxygenase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Mitogen-activated Protein Kinase Binding
Biological Process
Response To Hypoxia
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Response To DNA Damage Stimulus
Protein Hydroxylation
Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline
Regulation Of Cell Proliferation
Regulation Of Neuron Apoptotic Process
Oxidation-reduction Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hypoxia
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Cell Cycle
Signal Transduction
Peptidyl-serine Phosphorylation
CAMP-mediated Signaling
Cell Differentiation
Negative Regulation Of CAMP Catabolic Process
Negative Regulation Of Heterotypic Cell-cell Adhesion
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Innate Immune Response
Regulation Of Angiogenesis
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Neurotrophin TRK Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Stress-activated MAPK Cascade
Negative Regulation Of NFAT Protein Import Into Nucleus
Negative Regulation Of Response To Cytokine Stimulus
Cellular Response To Hydrogen Peroxide
Cellular Response To Growth Factor Stimulus
Cellular Response To Laminar Fluid Shear Stress
Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Endothelial Cell Apoptotic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Cellular response to hypoxia
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Signaling by GPCR
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cellular Senescence
ERKs are inactivated
Toll Like Receptor TLR6:TLR2 Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
Gastrin-CREB signalling pathway via PKC and MAPK
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
ERK/MAPK targets
Innate Immune System
Signalling to ERK5
ERKs are inactivated
Signalling by NGF
TRIF-mediated TLR3/TLR4 signaling
MAP kinase activation in TLR cascade
Senescence-Associated Secretory Phenotype (SASP)
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 3 (TLR3) Cascade
ERK/MAPK targets
Toll Like Receptor 4 (TLR4) Cascade
MAPK targets/ Nuclear events mediated by MAP kinases
Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-Protein Interactions
22 interactors:
ABI2
ADRB2
ATF4
EFHC2
EPAS1
FOXJ2
HIF1A
HIF3A
IKBKG
MAPK1
MAPK6
MAPK7
NCAPH2
OS9
PKM
PRPF19
REL
SERTAD1
SIAH2
SQSTM1
TTC23L
WDR83
27 interactors:
ACTN4
APP
C5orf30
EGLN3
ELK4
ETS1
FGF21
FOS
GJA1
GOLGB1
MAP2K5
MEF2A
MEF2C
MEF2D
MYC
NFE2L2
NR1I2
PRKCZ
PTPRR
RAF1
RXRA
SGK1
SH2D2A
UBE2C
YWHAB
YWHAE
ZBED6CL
Entrez ID
112399
5598
HPRD ID
06972
03952
Ensembl ID
ENSG00000129521
ENSG00000166484
Uniprot IDs
Q9H6Z9
Q13164
PDB IDs
2Q8Y
4B99
4IC7
4IC8
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Stress
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Regulation Of Transcription From RNA Polymerase II Promoter
Intracellular Signal Transduction
Regulation Of RNA Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Metabolic Process
Negative Regulation Of Oxidative Stress-induced Cell Death
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Response To Stress
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Signal Transduction
Negative Regulation Of Cell Death
Regulation Of Cellular Response To Oxidative Stress
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
RNA Metabolic Process
Signaling
Cellular Response To Stimulus
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Cell Communication
Regulation Of Gene Expression
TRIF-dependent Toll-like Receptor Signaling Pathway
Cellular Response To Oxidative Stress
Negative Regulation Of Oxidative Stress-induced Neuron Death
MyD88-independent Toll-like Receptor Signaling Pathway
Negative Regulation Of Neuron Death
Toll-like Receptor 3 Signaling Pathway
Gene Expression
Regulation Of Protein Metabolic Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of Transcription, DNA-templated
MAPK Cascade
Positive Regulation Of Protein Metabolic Process
Toll-like Receptor 4 Signaling Pathway
Transcription, DNA-templated
Response To Fluid Shear Stress
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Apoptotic Process
Programmed Cell Death
Cellular Response To Growth Factor Stimulus
Cell Death
Death
Positive Regulation Of Metabolic Process
Response To Growth Factor
Negative Regulation Of Cellular Metabolic Process
Regulation Of Apoptotic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Fluid Shear Stress
Regulation Of Cell Death
Positive Regulation Of Protein Metabolic Process
Regulation Of Metabolic Process
MAPK Cascade
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Response To Organic Substance
Positive Regulation Of Behavioral Fear Response
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Regulation Of Phosphorus Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cellular Response To Organic Substance
Positive Regulation Of Macromolecule Biosynthetic Process
Signal Transduction By Phosphorylation
Positive Regulation Of Gene Expression
Regulation Of Cellular Component Organization
Cellular Response To Stimulus
Positive Regulation Of Cellular Biosynthetic Process
Response To Stress
Positive Regulation Of Transcription, DNA-templated
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Neurotrophin Signaling Pathway
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Cell Proliferation
Cardiac Conduction
Regulation Of Signal Transduction
Cardiovascular System Development
Regulation Of RNA Metabolic Process
Regulation Of MAPK Cascade
Learning Or Memory
Anatomical Structure Morphogenesis
Signal Transduction
Response To Hormone
Tagcloud
?
altering
avenue
cyclin
d1
deubiquitinase
egln1
egln2
foxo
foxo3a
hif
hydroxylases
hydroxylate
hydroxylation
insights
leads
pharmacologically
prevents
prolyl
promotes
promoting
proteasomal
regulate
repress
stability
suppresses
thereby
turn
usp9x
Tagcloud (Difference)
?
altering
avenue
cyclin
d1
deubiquitinase
egln1
egln2
foxo
foxo3a
hif
hydroxylases
hydroxylate
hydroxylation
insights
leads
pharmacologically
prevents
prolyl
promotes
promoting
proteasomal
regulate
repress
stability
suppresses
thereby
turn
usp9x
Tagcloud (Intersection)
?