EGLN3 and ZC2HC1A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EGLN3	ZC2HC1A
Description		egl-9 family hypoxia inducible factor 3	zinc finger C2HC-type containing 1A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Iron Ion Binding Protein Binding Ferrous Iron Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen 2-oxoglutarate-dependent Dioxygenase Activity L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity Metal Ion Binding Dioxygenase Activity Hypoxia-inducible Factor-proline Dioxygenase Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Apoptotic Process DNA Damage Response Protein Hydroxylation Regulation Of Neuron Apoptotic Process Cellular Response To Hypoxia
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs		Ascorbic acid Roxadustat Daprodustat Vadadustat
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Red blood cell count ( 32888494)	Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 24076602) Neutrophil percentage of white cells ( 32888494) Systemic lupus erythematosus ( 28714469) Weight ( 28552196)
Interacting Genes		40 interacting genes: ABI2 ADRB2 ATF4 CDC20 CFTR CTBP2 DUSP7 EFHC2 EPAS1 EPOR FAM168B FOXJ2 GSC2 HIF1A HIF3A IK IKBKG IKZF3 LDB2 LNX1 MAPK1 MAPK7 MDM2 NCAPH2 NTAQ1 OS9 PKM PLEKHA2 PRPF19 RBBP8NL SERTAD1 SIAH2 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83 ZC2HC1A ZNF655	11 interacting genes: APP CBFA2T2 EGLN3 EXOC8 LASP1 MAPRE3 NCK2 RAD54L2 SP100 WBP4 YES1
Entrez ID		112399	51101
HPRD ID		06972	13039
Ensembl ID		ENSG00000129521	ENSG00000104427
Uniprot IDs		B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9	B2R9B8 H0YAP0 Q96GY0
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Nuclear Speck Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Protein Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Intracellular Oxygen Homeostasis Cellular Response To Oxygen Levels Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Hypoxia Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Sumoylation PML Body Protein Tag Activity Regulation Of Nucleobase-containing Compound Metabolic Process Response To Decreased Oxygen Levels Positive Regulation Of RNA Metabolic Process Cellular Response To Stress Response To Oxygen Levels Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Response To Actinomycin D Transcription Regulator Complex Cytoplasm Protein Modification By Small Protein Conjugation Positive Regulation Of Macromolecule Metabolic Process Identical Protein Binding Response To Actinomycin D Ubiquitin-like Protein Ligase Binding Regulation Of Apoptotic Signaling Pathway Enzyme Binding Embryonic Organ Development Intracellular Signal Transduction Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Binding Cellular Response To UV-C Regulation Of Primary Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Biosynthetic Process Protein Modification Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Serine/threonine Kinase Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of RNA Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Cell Activation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Endosome To Plasma Membrane Transport Vesicle Regulation Of Supramolecular Fiber Organization Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Retinoic Acid Mitotic Spindle Astral Microtubule End Peptidyl-proline 4-dioxygenase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?