EGLN3 and RBBP8NL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EGLN3	RBBP8NL
Description		egl-9 family hypoxia inducible factor 3	RBBP8 N-terminal like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Extracellular Space
	Molecular Function	Iron Ion Binding Protein Binding Ferrous Iron Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen 2-oxoglutarate-dependent Dioxygenase Activity L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity Metal Ion Binding Dioxygenase Activity Hypoxia-inducible Factor-proline Dioxygenase Activity	Protein Binding
	Biological Process	Apoptotic Process DNA Damage Response Protein Hydroxylation Regulation Of Neuron Apoptotic Process Cellular Response To Hypoxia
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs		Ascorbic acid Roxadustat Daprodustat Vadadustat
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Red blood cell count ( 32888494)
Interacting Genes		40 interacting genes: ABI2 ADRB2 ATF4 CDC20 CFTR CTBP2 DUSP7 EFHC2 EPAS1 EPOR FAM168B FOXJ2 GSC2 HIF1A HIF3A IK IKBKG IKZF3 LDB2 LNX1 MAPK1 MAPK7 MDM2 NCAPH2 NTAQ1 OS9 PKM PLEKHA2 PRPF19 RBBP8NL SERTAD1 SIAH2 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83 ZC2HC1A ZNF655	9 interacting genes: ARPC3 CHIA CTBP2 EGLN3 LARP1B NCK2 PHF1 PIN1 POLR3C
Entrez ID		112399	140893
HPRD ID		06972	12751
Ensembl ID		ENSG00000129521	ENSG00000130701
Uniprot IDs		B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9	Q8NC74
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Nuclear Speck Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Protein Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Intracellular Oxygen Homeostasis Cellular Response To Oxygen Levels Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Hypoxia Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Sumoylation PML Body Protein Tag Activity Regulation Of Nucleobase-containing Compound Metabolic Process Response To Decreased Oxygen Levels Positive Regulation Of RNA Metabolic Process Cellular Response To Stress Response To Oxygen Levels Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Response To Actinomycin D Transcription Regulator Complex Cytoplasm Protein Modification By Small Protein Conjugation Positive Regulation Of Macromolecule Metabolic Process Identical Protein Binding Response To Actinomycin D Ubiquitin-like Protein Ligase Binding Regulation Of Apoptotic Signaling Pathway Enzyme Binding Embryonic Organ Development Intracellular Signal Transduction Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Binding Cellular Response To UV-C Regulation Of Primary Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Biosynthetic Process Protein Modification Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Positive Regulation Of Biosynthetic Process Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Corepressor Binding Site Of Double-strand Break Response To Stress Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Cis-trans Isomerase Activity Supramolecular Fiber Organization Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Gene Expression Regulation Of Actin Filament Length Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Growth Cone Leading Edge Polysaccharide Digestion Chitin Metabolic Process Endochitinase Activity Chitin Catabolic Process Chitinase Activity Hypoxia-inducible Factor-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Response To Oxygen Levels Phosphoserine Residue Binding Positive Regulation Of Translation Histone H3K36me3 Reader Activity Positive Regulation Of Translation In Response To Stress Actin Polymerization-dependent Cell Motility Chitin Binding Signal Complex Assembly
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