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EGLN3 and WDR83
Number of citations of the paper that reports this interaction (PMID
16407229
)
12
Data Source:
HPRD
(in vivo, in vitro, two hybrid)
EGLN3
WDR83
Gene Name
egl-9 family hypoxia-inducible factor 3
WD repeat domain 83
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Spliceosomal Complex
Cytoplasm
Catalytic Step 2 Spliceosome
Molecular Function
Iron Ion Binding
Protein Binding
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors
L-ascorbic Acid Binding
Peptidyl-proline 4-dioxygenase Activity
Protein Binding
Biological Process
Response To Hypoxia
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Response To DNA Damage Stimulus
Protein Hydroxylation
Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline
Regulation Of Cell Proliferation
Regulation Of Neuron Apoptotic Process
Oxidation-reduction Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hypoxia
RNA Splicing, Via Transesterification Reactions
MRNA Splicing, Via Spliceosome
Pathways
Cellular response to hypoxia
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs
Diseases
GWAS
Protein-Protein Interactions
22 interactors:
ABI2
ADRB2
ATF4
EFHC2
EPAS1
FOXJ2
HIF1A
HIF3A
IKBKG
MAPK1
MAPK6
MAPK7
NCAPH2
OS9
PKM
PRPF19
REL
SERTAD1
SIAH2
SQSTM1
TTC23L
WDR83
17 interactors:
AQR
BAG2
CRB3
EGLN3
GNB2L1
GPKOW
HNRNPH2
HSPB1
KDM1A
KEAP1
LSM3
PARD6A
PARD6B
PCBP2
SAP30BP
SF1
TOE1
Entrez ID
112399
84292
HPRD ID
06972
14730
Ensembl ID
ENSG00000129521
ENSG00000123154
Uniprot IDs
Q9H6Z9
Q9BRX9
PDB IDs
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Stress
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Regulation Of Transcription From RNA Polymerase II Promoter
Intracellular Signal Transduction
Regulation Of RNA Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Metabolic Process
Negative Regulation Of Oxidative Stress-induced Cell Death
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Response To Stress
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Signal Transduction
Negative Regulation Of Cell Death
Regulation Of Cellular Response To Oxidative Stress
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
RNA Metabolic Process
Signaling
Cellular Response To Stimulus
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Cell Communication
Regulation Of Gene Expression
TRIF-dependent Toll-like Receptor Signaling Pathway
Cellular Response To Oxidative Stress
Negative Regulation Of Oxidative Stress-induced Neuron Death
MyD88-independent Toll-like Receptor Signaling Pathway
Negative Regulation Of Neuron Death
Toll-like Receptor 3 Signaling Pathway
Gene Expression
Regulation Of Protein Metabolic Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of Transcription, DNA-templated
MAPK Cascade
Positive Regulation Of Protein Metabolic Process
Toll-like Receptor 4 Signaling Pathway
Transcription, DNA-templated
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
RNA Splicing
Tight Junction Assembly
MRNA Processing
Apical Junction Assembly
MRNA Metabolic Process
RNA Processing
Cell-cell Junction Assembly
Gene Expression
Negative Regulation Of Oxidative Stress-induced Cell Death
Regulation Of Intrinsic Apoptotic Signaling Pathway
Cell Junction Assembly
Cell-cell Junction Organization
Regulation Of Cellular Response To Oxidative Stress
RNA Metabolic Process
Regulation Of Primitive Erythrocyte Differentiation
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis
Positive Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of CAMP Catabolic Process
Heterocycle Metabolic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Hydrogen Peroxide-induced Neuron Death
Zymogen Activation
Negative Regulation Of Intracellular Signal Transduction
Regulation Of Cell Death
Primary Sex Determination
Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Proteasomal Ubiquitin-independent Protein Catabolic Process
Regulation Of Embryonic Development
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway
MRNA 3'-splice Site Recognition
Positive Regulation Of Endopeptidase Activity
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Female Gonad Development
Nitrogen Compound Metabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Peptidase Activity
Negative Regulation Of Oxidative Stress-induced Neuron Death
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Histone H3-K4 Methylation
Tagcloud
?
altering
avenue
cyclin
d1
deubiquitinase
egln1
egln2
foxo
foxo3a
hif
hydroxylases
hydroxylate
hydroxylation
insights
leads
pharmacologically
prevents
prolyl
promotes
promoting
proteasomal
regulate
repress
stability
suppresses
thereby
turn
usp9x
Tagcloud (Difference)
?
altering
avenue
cyclin
d1
deubiquitinase
egln1
egln2
foxo
foxo3a
hif
hydroxylases
hydroxylate
hydroxylation
insights
leads
pharmacologically
prevents
prolyl
promotes
promoting
proteasomal
regulate
repress
stability
suppresses
thereby
turn
usp9x
Tagcloud (Intersection)
?