EGLN3 and NCAPH2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		EGLN3	NCAPH2
Gene Name		egl-9 family hypoxia-inducible factor 3	non-SMC condensin II complex, subunit H2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleoplasm Chromosome Membrane
	Molecular Function	Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity	Protein Binding
	Biological Process	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Proliferation Regulation Of Neuron Apoptotic Process Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia	Mitotic Cell Cycle Chromosome Condensation
Pathways		Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Mitotic Prophase Condensation of Prophase Chromosomes Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			Mean corpuscular hemoglobin ( 20139978) Red blood cell traits ( 23222517)
Protein-Protein Interactions		22 interactors: ABI2 ADRB2 ATF4 EFHC2 EPAS1 FOXJ2 HIF1A HIF3A IKBKG MAPK1 MAPK6 MAPK7 NCAPH2 OS9 PKM PRPF19 REL SERTAD1 SIAH2 SQSTM1 TTC23L WDR83	5 interactors: EGLN3 FOLR1 LMO2 SNRPC USHBP1
Entrez ID		112399	29781
HPRD ID		06972	11783
Ensembl ID		ENSG00000129521	ENSG00000025770
Uniprot IDs		Q9H6Z9	Q6IBW4
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stress Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Metabolic Process Negative Regulation Of Oxidative Stress-induced Cell Death Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Response To Stress Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Signal Transduction Negative Regulation Of Cell Death Regulation Of Cellular Response To Oxidative Stress Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway RNA Metabolic Process Signaling Cellular Response To Stimulus Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cell Communication Regulation Of Gene Expression TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Oxidative Stress Negative Regulation Of Oxidative Stress-induced Neuron Death MyD88-independent Toll-like Receptor Signaling Pathway Negative Regulation Of Neuron Death Toll-like Receptor 3 Signaling Pathway Gene Expression Regulation Of Protein Metabolic Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Transcription, DNA-templated MAPK Cascade Positive Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Transcription, DNA-templated	MRNA 5'-splice Site Recognition Cellular Modified Amino Acid Metabolic Process Alpha-amino Acid Metabolic Process Folic Acid Transport Negative Regulation Of Erythrocyte Differentiation Heterocycle Metabolic Process Cellular Response To Thyroid Hormone Stimulus Folic Acid Metabolic Process MRNA Transcription From RNA Polymerase II Promoter Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Cellular Amino Acid Metabolic Process MRNA Transcription Response To Thyroid Hormone MRNA Cis Splicing, Via Spliceosome Nitrogen Compound Metabolic Process 4-hydroxyproline Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Peptidyl-proline Hydroxylation Protein Hydroxylation Embryonic Hemopoiesis Regulation Of Erythrocyte Differentiation Cofactor Transport Spliceosomal SnRNP Assembly MRNA Splice Site Selection
Tagcloud ?		altering avenue cyclin d1 deubiquitinase egln1 egln2 foxo foxo3a hif hydroxylases hydroxylate hydroxylation insights leads pharmacologically prevents prolyl promotes promoting proteasomal regulate repress stability suppresses thereby turn usp9x
Tagcloud (Difference) ?		altering avenue cyclin d1 deubiquitinase egln1 egln2 foxo foxo3a hif hydroxylases hydroxylate hydroxylation insights leads pharmacologically prevents prolyl promotes promoting proteasomal regulate repress stability suppresses thereby turn usp9x
Tagcloud (Intersection) ?