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EGLN3 and EFHC2
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
EGLN3
EFHC2
Gene Name
egl-9 family hypoxia-inducible factor 3
EF-hand domain (C-terminal) containing 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Iron Ion Binding
Protein Binding
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors
L-ascorbic Acid Binding
Peptidyl-proline 4-dioxygenase Activity
Calcium Ion Binding
Biological Process
Response To Hypoxia
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Response To DNA Damage Stimulus
Protein Hydroxylation
Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline
Regulation Of Cell Proliferation
Regulation Of Neuron Apoptotic Process
Oxidation-reduction Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hypoxia
Pathways
Cellular response to hypoxia
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs
Diseases
GWAS
Protein-Protein Interactions
22 interactors:
ABI2
ADRB2
ATF4
EFHC2
EPAS1
FOXJ2
HIF1A
HIF3A
IKBKG
MAPK1
MAPK6
MAPK7
NCAPH2
OS9
PKM
PRPF19
REL
SERTAD1
SIAH2
SQSTM1
TTC23L
WDR83
30 interactors:
ARHGEF5
ARMC7
CCDC120
CCHCR1
CCNG2
CLIC3
COPE
CYFIP1
DGCR6
EDC3
EGLN3
EMD
EXOC8
JAKMIP2
KIF9
LONRF1
MAPK9
NCDN
NCK2
NDOR1
PBLD
PLOD3
PTK6
RUNX1T1
SNRNP25
SPG21
STK16
TRIM42
TSSK3
TUBGCP4
Entrez ID
112399
80258
HPRD ID
06972
06540
Ensembl ID
ENSG00000129521
Uniprot IDs
Q9H6Z9
Q5JST6
PDB IDs
2Z13
2Z14
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Stress
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Regulation Of Transcription From RNA Polymerase II Promoter
Intracellular Signal Transduction
Regulation Of RNA Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Metabolic Process
Negative Regulation Of Oxidative Stress-induced Cell Death
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Response To Stress
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Signal Transduction
Negative Regulation Of Cell Death
Regulation Of Cellular Response To Oxidative Stress
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
RNA Metabolic Process
Signaling
Cellular Response To Stimulus
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Cell Communication
Regulation Of Gene Expression
TRIF-dependent Toll-like Receptor Signaling Pathway
Cellular Response To Oxidative Stress
Negative Regulation Of Oxidative Stress-induced Neuron Death
MyD88-independent Toll-like Receptor Signaling Pathway
Negative Regulation Of Neuron Death
Toll-like Receptor 3 Signaling Pathway
Gene Expression
Regulation Of Protein Metabolic Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of Transcription, DNA-templated
MAPK Cascade
Positive Regulation Of Protein Metabolic Process
Toll-like Receptor 4 Signaling Pathway
Transcription, DNA-templated
Regulation Of Podosome Assembly
Tagcloud
?
altering
avenue
cyclin
d1
deubiquitinase
egln1
egln2
foxo
foxo3a
hif
hydroxylases
hydroxylate
hydroxylation
insights
leads
pharmacologically
prevents
prolyl
promotes
promoting
proteasomal
regulate
repress
stability
suppresses
thereby
turn
usp9x
Tagcloud (Difference)
?
altering
avenue
cyclin
d1
deubiquitinase
egln1
egln2
foxo
foxo3a
hif
hydroxylases
hydroxylate
hydroxylation
insights
leads
pharmacologically
prevents
prolyl
promotes
promoting
proteasomal
regulate
repress
stability
suppresses
thereby
turn
usp9x
Tagcloud (Intersection)
?