LIMA1 and CRYAA

Number of citations of the paper that reports this interaction (PubMedID 24453475)
30

Data Source:
BioGRID (pull down)

		LIMA1	CRYAA
Description		LIM domain and actin binding 1	crystallin alpha A
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GO Annotations	Cellular Component	Stress Fiber Ruffle Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Brush Border Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Brush Border Membrane Cleavage Furrow Cell Projection Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Cadherin Binding Metal Ion Binding Actin Filament Binding Microtubule Stabilizing Activity	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Cell Migration Intestinal Cholesterol Absorption Negative Regulation Of Cell Migration Negative Regulation Of Actin Filament Depolymerization Ruffle Organization Positive Regulation Of Actin Filament Bundle Assembly Cholesterol Homeostasis Actin Filament Bundle Assembly Negative Regulation Of Cilium Assembly Regulation Of Lamellipodium Organization	Response To Hypoxia Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Apoptotic Process Mitochondrion Organization Actin Filament Organization Microtubule-based Process Tubulin Complex Assembly Visual Perception Response To Heat Negative Regulation Of Gene Expression Positive Regulation Of Cell Growth Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Embryonic Camera-type Eye Morphogenesis Protein Stabilization Apoptotic Process Involved In Morphogenesis Response To UV-A Lens Fiber Cell Morphogenesis
Pathways
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Colorectal or endometrial cancer ( 26621817) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731)	Age-related nuclear cataracts ( 24951543 33311586) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Metabolite levels ( 23823483) Systolic blood pressure ( 27618452 27841878 28739976)
Interacting Genes		10 interacting genes: APP CRYAA DAPK1 MFHAS1 PTEN UBC USP7 XIAP YWHAG YWHAQ	134 interacting genes: - ADPRHL1 AKT3 ALB ALDH1L2 ANKRD44 APPL2 ARFGAP1 ARMCX4 ARRDC1-AS1 ATG16L1 BCL2L1 BORA BTRC CAMKK2 CD209 CDC40 CEBPZ CENPH CER1 CNOT8 COPB2 CRTAC1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS CSTF2T DCAF11 DCAF8 DCK DDX3X DUS4L E2F7 EEPD1 ETFB EYA4 FAM131B FAM131C FAM182A FASN GIGYF2 GLYATL1 GNAI2 GORASP2 GSTZ1 HABP4 HCLS1 HSPB1 HSPB2 IGHG1 IGKV1-5 JKAMP KBTBD12 KIZ KNG1 LALBA LARP6 LIMA1 MAP3K7CL MAPKBP1 MCM7 MCRS1 MINDY1 MIP MPHOSPH6 MTERF4 MYO5C NAT9 NCF4 NTAQ1 NUP43 OSBPL3 OTOGL OTULIN PABIR2 PAFAH1B1 PCYT2 PHC1 PLAUR PMS2 PRM2 PSMB6 PTPN2 PTTG2 QRICH1 RAB24 RAB29 RAB3C RAB40B RAB43 RAD51 RBBP7 RNASEH1 RNGTT RPS6KA5 SDCBP SEC24C SEH1L SESN2 SGCD SLC20A1 SLC25A25 SLC25A26 SLC25A28 SPG21 SSBP4 SULF1 SYK TASL TEAD4 TFDP1 TGOLN2 TLE4 TMEM254 TMEM52B TSR3 TTC27 TTC39B TUBAL3 TUBGCP5 UBR2 UPP1 WDR55 WDR83 WIPI2 WWC2 ZIM2 ZNF3 ZNF639 ZSCAN20
Entrez ID		51474	1409
HPRD ID		09755	00427
Ensembl ID		ENSG00000050405	ENSG00000160202
Uniprot IDs		Q9UHB6	A0A8C8KJZ9 P02489
PDB IDs		2D8Y	6T1R
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Protein Stabilization Identical Protein Binding Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of JNK Cascade Negative Regulation Of Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Apoptotic Process Response To Stress Negative Regulation Of Cell Communication Negative Regulation Of Biosynthetic Process Copper Ion Homeostasis Regulation Of JNK Cascade Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Protein Serine/threonine Kinase Binding Regulation Of Protein Stability Cell Death Programmed Cell Death Regulation Of Transport Protein Modification Process Cytoplasm Regulation Of Response To Tumor Cell Positive Regulation Of Excitatory Postsynaptic Potential Reproductive Behavior Positive Regulation Of Catabolic Process Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process Neuron Projection Organization Protein Ubiquitination Protein Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Localization To Nucleus Modulation Of Excitatory Postsynaptic Potential Regulation Of Signal Transduction Signal Transduction Protein Modification By Small Protein Conjugation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction TORC1 Signaling	Structural Constituent Of Eye Lens Lens Development In Camera-type Eye
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