LIMA1

Description		LIM domain and actin binding 1
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GO Annotations	Cellular Component	Stress Fiber Ruffle Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Brush Border Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Brush Border Membrane Cleavage Furrow Cell Projection Anchoring Junction
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Cadherin Binding Metal Ion Binding Actin Filament Binding Microtubule Stabilizing Activity
	Biological Process	Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Cell Migration Intestinal Cholesterol Absorption Negative Regulation Of Cell Migration Negative Regulation Of Actin Filament Depolymerization Ruffle Organization Positive Regulation Of Actin Filament Bundle Assembly Cholesterol Homeostasis Actin Filament Bundle Assembly Negative Regulation Of Cilium Assembly Regulation Of Lamellipodium Organization
Pathways
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Colorectal or endometrial cancer ( 26621817) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731)
Interacting Genes		10 interacting genes: APP CRYAA DAPK1 MFHAS1 PTEN UBC USP7 XIAP YWHAG YWHAQ
Entrez ID		51474
HPRD ID		09755
Ensembl ID		ENSG00000050405
Uniprot IDs		Q9UHB6
PDB IDs		2D8Y
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Protein Stabilization Identical Protein Binding Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of JNK Cascade Negative Regulation Of Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Apoptotic Process Response To Stress Negative Regulation Of Cell Communication Negative Regulation Of Biosynthetic Process Copper Ion Homeostasis Regulation Of JNK Cascade Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Protein Serine/threonine Kinase Binding Regulation Of Protein Stability Cell Death Programmed Cell Death Regulation Of Transport Protein Modification Process Cytoplasm Regulation Of Response To Tumor Cell Positive Regulation Of Excitatory Postsynaptic Potential Reproductive Behavior Positive Regulation Of Catabolic Process Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process Neuron Projection Organization Protein Ubiquitination Protein Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Localization To Nucleus Modulation Of Excitatory Postsynaptic Potential Regulation Of Signal Transduction Signal Transduction Protein Modification By Small Protein Conjugation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction TORC1 Signaling
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