LIMA1 and DAPK1

Number of citations of the paper that reports this interaction (PubMedID 32707033)
104

Data Source:
BioGRID (pull down, affinity chromatography technology)

		LIMA1	DAPK1
Description		LIM domain and actin binding 1	death associated protein kinase 1
Image
GO Annotations	Cellular Component	Stress Fiber Ruffle Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Brush Border Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Brush Border Membrane Cleavage Furrow Cell Projection Anchoring Junction	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Postsynaptic Density Actin Cytoskeleton Organelle Glutamatergic Synapse DAPK1-calmodulin Complex
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Cadherin Binding Metal Ion Binding Actin Filament Binding Microtubule Stabilizing Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Syntaxin-1 Binding Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Cell Migration Intestinal Cholesterol Absorption Negative Regulation Of Cell Migration Negative Regulation Of Actin Filament Depolymerization Ruffle Organization Positive Regulation Of Actin Filament Bundle Assembly Cholesterol Homeostasis Actin Filament Bundle Assembly Negative Regulation Of Cilium Assembly Regulation Of Lamellipodium Organization	Defense Response To Tumor Cell Regulation Of Response To Tumor Cell Regulation Of Translation Protein Phosphorylation Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Autophagy Positive Regulation Of Autophagy Negative Regulation Of Translation Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Protein Autophosphorylation Cellular Response To Type II Interferon Cellular Response To Hydroperoxide Apoptotic Signaling Pathway Positive Regulation Of Autophagic Cell Death Regulation Of NMDA Receptor Activity
Pathways			Caspase activation via Dependence Receptors in the absence of ligand
Drugs			5,6-Dihydro-Benzo[H]Cinnolin-3-Ylamine Phosphoaminophosphonic Acid-Adenylate Ester 6-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE Fostamatinib
Diseases			Bladder cancer
GWAS		Apolipoprotein B levels ( 32203549) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Colorectal or endometrial cancer ( 26621817) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731)	Blood pressure ( 24954895) Cognitive function ( 24684796) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Height ( 31562340) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Night sleep phenotypes ( 27126917) Ovarian cancer ( 30557369) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to gemcitabine in pancreatic cancer ( 22293537)
Interacting Genes		10 interacting genes: APP CRYAA DAPK1 MFHAS1 PTEN UBC USP7 XIAP YWHAG YWHAQ	109 interacting genes: ABL1 ABLIM1 AHDC1 APEX2 ARRDC1 ARRDC1-AS1 ATF6 BAG2 BAIAP2 C11orf65 CALM1 CAPRIN1 CBLB CCDC149 CDC42EP3 CDC42SE1 CMTM4 CNTROB DENND1C DTWD1 DUS1L DUX3 EIF4ENIF1 EPHA1 FADD FAM107A FBXL14 FBXW11 FIBP GASK1B GTF2F1 HYCC2 IKBKG JHY LIMA1 LIMS1 LINC02875 LMF2 LNX1 LOXL2 MAPK1 MAPK3 MCM10 MDM2 MIB1 MRGBP MTHFD2 MYL12B NCBP3 NECAB1 NECAP1 NR3C1 ORMDL2 PAK6 PAPSS2 PCP4 PHKG2 PIM1 PIM2 POLR2M PPP1R14A PPP2R1A PPP2R2D PPP2R5A PRKAG2 PRR16 PRRC2B PWP1 RAPGEF3 RASGRP2 RCHY1 RFC5 RHBDD1 RPAP3 RPL41 SARNP SCEL SCRN3 SCYL1 SGK2 SH2D2A SLAIN2 SNRPA SNURF SNX9 SPATS2 SPRR2G SRSF10 STARD3 STUB1 STX1A TAS2R60 TBC1D22B TNFRSF1A TPD52L1 TRADD TRAPPC2 TTC27 TUBB4B UNC5A UNC5B UNC5C VGLL4 VN1R1 WWTR1 YWHAB ZAP70 ZMAT4 ZMYM5
Entrez ID		51474	1612
HPRD ID		09755	02902
Ensembl ID		ENSG00000050405	ENSG00000196730
Uniprot IDs		Q9UHB6	B4DHI4 P53355 Q59H88
PDB IDs		2D8Y	1IG1 1JKK 1JKL 1JKS 1JKT 1P4F 1WVW 1WVX 1WVY 1YR5 2W4J 2W4K 2X0G 2XUU 2XZS 2Y0A 2Y4P 2Y4V 2YAK 3DFC 3DGK 3EH9 3EHA 3F5G 3F5U 3GU4 3GU5 3GU6 3GU7 3GU8 3GUB 3ZXT 4B4L 4PF4 4TL0 4TXC 4UV0 4YO4 4YPD 5AUT 5AUU 5AUV 5AUW 5AUX 5AUY 5AUZ 5AV0 5AV1 5AV2 5AV3 5AV4 6AAR 6FHA 6FHB 6GY5 6IN4 6QMO 6QN4 7CCU 7CCV 7CCW 8IE5 8IE6 8IE7 8IE8 8ODZ 8OE0 8OE4 8PB1 9DUB 9DUE 9INV 9INW 9INX 9MIU
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Protein Stabilization Identical Protein Binding Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of JNK Cascade Negative Regulation Of Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Apoptotic Process Response To Stress Negative Regulation Of Cell Communication Negative Regulation Of Biosynthetic Process Copper Ion Homeostasis Regulation Of JNK Cascade Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Protein Serine/threonine Kinase Binding Regulation Of Protein Stability Cell Death Programmed Cell Death Regulation Of Transport Protein Modification Process Cytoplasm Regulation Of Response To Tumor Cell Positive Regulation Of Excitatory Postsynaptic Potential Reproductive Behavior Positive Regulation Of Catabolic Process Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process Neuron Projection Organization Protein Ubiquitination Protein Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Localization To Nucleus Modulation Of Excitatory Postsynaptic Potential Regulation Of Signal Transduction Signal Transduction Protein Modification By Small Protein Conjugation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction TORC1 Signaling	Cytosol Netrin Receptor Activity Phosphotyrosine Residue Binding Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Catabolic Process Positive Regulation Of Proteolysis Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Positive Regulation Of Cytoskeleton Organization Bergmann Glial Cell Differentiation Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Astrocyte Differentiation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-34-mediated Signaling Pathway Regulation Of Protein Stability Protein Phosphatase Type 2A Complex Apoptotic Process Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Golgi Inheritance Tumor Necrosis Factor Receptor Superfamily Complex Thymus Development Programmed Cell Death Cell Death Cytoplasm Positive Regulation Of Organelle Organization Protein Kinase Activity Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation ERBB2 Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Kinase Binding Endocytosis Regulation Of Cytoskeleton Organization Receptor Serine/threonine Kinase Binding Protein Domain Specific Binding Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Actin Filament Bundle Assembly T Cell Receptor Signaling Pathway Lymphocyte Homeostasis Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Death-inducing Signaling Complex
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