PHF21A and HIST2H3C

Number of citations of the paper that reports this interaction (PMID 17687328)
108

Data Source:
BioGRID (pull down, x-ray crystallography)

		PHF21A	HIST2H3C
Gene Name		PHD finger protein 21A	histone cluster 2, H3c
Image
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleoplasm	Nucleosome Extracellular Region Nucleus Nucleoplasm Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Chromatin Binding Zinc Ion Binding	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Suckling Behavior Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Blood Coagulation Chromatin Modification	Chromatin Silencing At RDNA Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways		Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones Factors involved in megakaryocyte development and platelet production	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS		Menarche (age at onset) ( 21102462)
Protein-Protein Interactions		13 interactors: BANP FHL3 HDAC1 HDAC2 HIST2H3C HMG20B KDM1A KRT40 LPXN NUP62 RCOR1 TRAF1 ZYX	61 interactors: ARID4A ATRX AURKB BIRC5 BRD1 BRD4 BRD7 BRPF1 CDCA8 CDK8 CHUK COPRS DDB2 DNMT3L EHMT2 ELP3 EP300 HDGFRP2 INCENP ING1 JADE1 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3A KDM4C KDM6A KMT2A KMT2B KMT2C KMT2D MSL2 MUM1 NAP1L4 NASP NCOA6 NRD1 PHF21A PIM1 PKN1 PRMT6 PTMA RBBP4 RBBP5 RERE RNF20 RNF4 RPS6KA5 SETD1A SETD1B SETD7 SMARCA4 SMYD2 STAT6 TBL1X UHRF1 VRK1 WHSC1
Entrez ID		51317	126961
HPRD ID		10516	11822
Ensembl ID		ENSG00000135365
Uniprot IDs		Q96BD5	Q71DI3
PDB IDs		2PUY 2YQL	2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Histone H4 Deacetylation Regulation Of Body Fluid Levels Chromatin Modification Wound Healing Response To Wounding Chromatin Organization Regulation Of Transcription, DNA-templated Organelle Organization Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Histone Deacetylation Protein Deacetylation RNA Biosynthetic Process Gene Expression Chromosome Organization Fungiform Papilla Formation Regulation Of Gene Expression Negative Regulation Of Gene Expression, Epigenetic Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Megakaryocyte Differentiation Fungiform Papilla Morphogenesis Positive Regulation Of Receptor Biosynthetic Process Fungiform Papilla Development Eyelid Development In Camera-type Eye Hair Follicle Placode Formation Negative Regulation Of Cellular Metabolic Process Tongue Morphogenesis Histone Modification Regulation Of Receptor Biosynthetic Process RNA Metabolic Process Regulation Of Megakaryocyte Differentiation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Muscle Structure Development Macromolecule Biosynthetic Process Histone H3 Deacetylation Chromatin Remodeling Cellular Nitrogen Compound Metabolic Process Regulation Of Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Signal Transduction Viral Process Negative Regulation Of Transcription, DNA-templated Tongue Development Negative Regulation Of Nucleic Acid-templated Transcription	Chromatin Modification Chromatin Organization Histone Modification Chromosome Organization Peptidyl-lysine Modification Organelle Organization Peptidyl-amino Acid Modification Transcription, DNA-templated RNA Biosynthetic Process Cellular Protein Modification Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Histone Methylation Gene Expression Peptidyl-lysine Methylation Methylation Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Protein Methylation Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone Lysine Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Protein Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Protein Metabolic Process Histone H3 Acetylation Positive Regulation Of Cellular Biosynthetic Process Histone H3-K4 Methylation Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression
Tagcloud ?		anaphase braf35 chromatid chromatids cohesin cohesion corepressor corest daughter demethlyase distribute esco2 establishment fused g9a gal4 hdac1 hdac2 k9 kept lsd1 methyltransferases possesses represses repressor segregation setdb1 sister suv39h1
Tagcloud (Difference) ?		anaphase braf35 chromatid chromatids cohesin cohesion corepressor corest daughter demethlyase distribute esco2 establishment fused g9a gal4 hdac1 hdac2 k9 kept lsd1 methyltransferases possesses represses repressor segregation setdb1 sister suv39h1
Tagcloud (Intersection) ?