PHF21A

Description		PHD finger protein 21A
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm DNA Repair Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization
Pathways		HDACs deacetylate histones Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Appendicular lean mass ( 33097823) Axial length ( 24144296) Height ( 29782485) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Menarche (age at onset) ( 21102462 25231870) Mild age-related type 2 diabetes ( 34737425) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Triglyceride levels ( 32203549) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		16 interacting genes: BANP EXOSC8 FHL2 FHL3 H3C14 HDAC1 HDAC2 HMG20B KDM1A KRT40 L3MBTL3 LPXN RCOR1 SP3 TRAF1 ZYX
Entrez ID		51317
HPRD ID		10516
Ensembl ID		ENSG00000135365
Uniprot IDs		Q96BD5
PDB IDs		2PUY 2YQL
Enriched GO Terms of Interacting Partners?		Chromatin Binding Chromatin Organization Protein Lysine Delactylase Activity Fungiform Papilla Formation Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Protein Decrotonylase Activity Histone Decrotonylase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Hair Follicle Placode Formation Histone Deacetylase Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Repressor Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Activity Negative Regulation Of Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Promoter-specific Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Lysine Deacetylase Activity Eyelid Development In Camera-type Eye Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides DNA Repair Complex Cell Differentiation NuRD Complex Nucleoplasm Histone Deacetylase Activity Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Oligodendrocyte Differentiation Sin3-type Complex Regulation Of Cell Fate Specification Regulation Of Chromatin Organization Negative Regulation Of Stem Cell Population Maintenance Histone Methyltransferase Complex Granulocyte Differentiation Cellular Developmental Process NF-kappaB Binding Enzyme Binding Regulation Of Androgen Receptor Signaling Pathway Focal Adhesion Regulation Of Intracellular Estrogen Receptor Signaling Pathway Nucleosomal DNA Binding Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation
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