PHF21A and LPXN

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PHF21A	LPXN
Description		PHD finger protein 21A	leupaxin
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm DNA Repair Complex	Podosome Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Nuclear Speck Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Transcription Coregulator Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization	Cell Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Endothelial Cell Migration Negative Regulation Of B Cell Receptor Signaling Pathway Protein-containing Complex Assembly
Pathways		HDACs deacetylate histones Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Appendicular lean mass ( 33097823) Axial length ( 24144296) Height ( 29782485) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Menarche (age at onset) ( 21102462 25231870) Mild age-related type 2 diabetes ( 34737425) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Triglyceride levels ( 32203549) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172)	Inflammatory bowel disease ( 23128233) Lymphoma ( 23349640) Pulse pressure ( 30578418) Ulcerative colitis ( 28067908)
Interacting Genes		16 interacting genes: BANP EXOSC8 FHL2 FHL3 H3C14 HDAC1 HDAC2 HMG20B KDM1A KRT40 L3MBTL3 LPXN RCOR1 SP3 TRAF1 ZYX	33 interacting genes: AGXT AQP1 GIT1 HDAC6 HOXA1 HOXC9 IKBKG IMP3 ITGA4 LIMS1 LMO1 LMO3 MAP2K7 MAPK6 NDN NR3C1 PHF21A PLEKHH2 PLEKHN1 PLSCR4 POM121 PTK2 PTK2B PTPN12 RNF214 RUNX1T1 SFI1 TGFB1 TNS2 TXLNB VCL ZNF175 ZNF426
Entrez ID		51317	9404
HPRD ID		10516	05651
Ensembl ID		ENSG00000135365	ENSG00000110031
Uniprot IDs		Q96BD5	B7Z5P7 O60711
PDB IDs		2PUY 2YQL	1X3H 4XEF 4XEK 4XEV
Enriched GO Terms of Interacting Partners?		Chromatin Binding Chromatin Organization Protein Lysine Delactylase Activity Fungiform Papilla Formation Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Protein Decrotonylase Activity Histone Decrotonylase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Hair Follicle Placode Formation Histone Deacetylase Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Repressor Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Activity Negative Regulation Of Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Promoter-specific Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Lysine Deacetylase Activity Eyelid Development In Camera-type Eye Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides DNA Repair Complex Cell Differentiation NuRD Complex Nucleoplasm Histone Deacetylase Activity Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Oligodendrocyte Differentiation Sin3-type Complex Regulation Of Cell Fate Specification Regulation Of Chromatin Organization Negative Regulation Of Stem Cell Population Maintenance Histone Methyltransferase Complex Granulocyte Differentiation Cellular Developmental Process NF-kappaB Binding Enzyme Binding Regulation Of Androgen Receptor Signaling Pathway Focal Adhesion Regulation Of Intracellular Estrogen Receptor Signaling Pathway Nucleosomal DNA Binding Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation	Response To Dexamethasone Focal Adhesion Positive Regulation Of Fibroblast Migration Developmental Growth Developmental Growth Involved In Morphogenesis Anchoring Junction Cellular Response To Dexamethasone Stimulus Cellular Response To Lipid Cellular Response To Oxygen-containing Compound Multicellular Organismal-level Homeostasis Positive Regulation Of Mononuclear Cell Migration Regulation Of Fibroblast Migration Response To Fluid Shear Stress Developmental Cell Growth Response To Lipid Signal Complex Assembly Regulation Of Cell-matrix Adhesion Response To Glucocorticoid Regulation Of Fat Cell Differentiation Cellular Response To Glucocorticoid Stimulus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Cellular Response To Growth Factor Stimulus Response To Corticosteroid Regulation Of RNA Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Corticosteroid Stimulus Anatomical Structure Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Focal Adhesion Assembly Regulation Of RNA Biosynthetic Process Response To Growth Factor Response To Transforming Growth Factor Beta Negative Regulation Of Nucleobase-containing Compound Metabolic Process ERBB Signaling Pathway Regulation Of Cell-substrate Junction Organization MAP Kinase Activity Regulation Of Primary Metabolic Process Regulation Of Cytoskeleton Organization Cellular Response To Steroid Hormone Stimulus Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neuron Projection Extension Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Migration Positive Regulation Of Catabolic Process Response To Wounding
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