PHF21A and EXOSC8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PHF21A	EXOSC8
Description		PHD finger protein 21A	exosome component 8
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm DNA Repair Complex	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway
Pathways		HDACs deacetylate histones Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Appendicular lean mass ( 33097823) Axial length ( 24144296) Height ( 29782485) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Menarche (age at onset) ( 21102462 25231870) Mild age-related type 2 diabetes ( 34737425) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Triglyceride levels ( 32203549) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		16 interacting genes: BANP EXOSC8 FHL2 FHL3 H3C14 HDAC1 HDAC2 HMG20B KDM1A KRT40 L3MBTL3 LPXN RCOR1 SP3 TRAF1 ZYX	112 interacting genes: AEN ANKHD1 ATF2 C22orf39 CCDC28A-AS1 CCL14 CCSER2 CNNM3 COL23A1 COX5A CPSF7 CRMP1 CWC22 DDIT4L DIS3 DUSP23 ERAL1 EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM161B FAM90A1 FHOD1 FOXD4L1 FOXN3 FRG1 FSAF1 FYTTD1 GEM HAPLN2 HOXB9 ILF2 INCA1 KANK2 KCNJ11 LENG1 LMO4 LNX1 LSM1 LSM4 LSM7 MACIR METTL14 MKRN1 MORN4 MRPL2 MTREX MYOZ1 NEDD9 NTAQ1 NXF1 OTUD4 PACSIN2 PALS2 PHF21A PIAS2 PKP2 POLDIP3 PRC1 PRPF31 PRPF6 PRR3 RASD1 RASSF1 RBBP4 RBM22 RBM7 REL RFC5 RPL3 RPLP0 RPP14 RPS28 RUSC1 RXRB SARNP SF1 SFPQ SGO2 SLAIN1 SLIRP SNAI1 SNRPA SNRPB SNRPC SNRPN SNW1 SOCS7 SPATC1L SRPK2 SRSF10 SUGP2 TBRG1 TCEA2 TFAP4 TFIP11 TXNDC17 TXNDC9 UBC UNKL UPF2 USP2 USP6 UTP14A XRN1 XRN2 ZFP36
Entrez ID		51317	11340
HPRD ID		10516	09351
Ensembl ID		ENSG00000135365	ENSG00000120699
Uniprot IDs		Q96BD5	Q96B26
PDB IDs		2PUY 2YQL	2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Chromatin Binding Chromatin Organization Protein Lysine Delactylase Activity Fungiform Papilla Formation Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Protein Decrotonylase Activity Histone Decrotonylase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Hair Follicle Placode Formation Histone Deacetylase Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Repressor Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Activity Negative Regulation Of Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Promoter-specific Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Lysine Deacetylase Activity Eyelid Development In Camera-type Eye Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides DNA Repair Complex Cell Differentiation NuRD Complex Nucleoplasm Histone Deacetylase Activity Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Oligodendrocyte Differentiation Sin3-type Complex Regulation Of Cell Fate Specification Regulation Of Chromatin Organization Negative Regulation Of Stem Cell Population Maintenance Histone Methyltransferase Complex Granulocyte Differentiation Cellular Developmental Process NF-kappaB Binding Enzyme Binding Regulation Of Androgen Receptor Signaling Pathway Focal Adhesion Regulation Of Intracellular Estrogen Receptor Signaling Pathway Nucleosomal DNA Binding Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation	RNA Binding MRNA Metabolic Process Exosome (RNase Complex) RNA Processing RNA Metabolic Process Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleic Acid Metabolic Process Nucleolar Exosome (RNase Complex) RNA Splicing, Via Transesterification Reactions Nucleus Nuclear-transcribed MRNA Catabolic Process Nuclear MRNA Surveillance RNA Catabolic Process MRNA Splicing, Via Spliceosome MRNA Catabolic Process RNA Exonuclease Activity MRNA Processing RNA Splicing Nucleoplasm Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Nuclear RNA Surveillance U4 SnRNA 3'-end Processing RNA Surveillance RRNA Catabolic Process 3'-5'-RNA Exonuclease Activity Nucleobase-containing Compound Catabolic Process Nucleic Acid Binding SnRNA Metabolic Process RRNA Metabolic Process RRNA Processing Catalytic Step 2 Spliceosome Poly(A)-dependent SnoRNA 3'-end Processing SnRNA 3'-end Processing Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Macromolecule Metabolic Process Nucleolus Exoribonuclease Complex Negative Regulation Of Macromolecule Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process SnRNA Processing RNA 3'-end Processing Negative Regulation Of Macromolecule Biosynthetic Process Protein Binding
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