PHF21A and SP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PHF21A	SP3
Description		PHD finger protein 21A	Sp3 transcription factor
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm DNA Repair Complex	Chromatin Nucleus Nucleoplasm Cytosol PML Body Transcription Repressor Complex Protein-DNA Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization	Negative Regulation Of Transcription By RNA Polymerase II Ossification In Utero Embryonic Development Natural Killer Cell Differentiation Trophectodermal Cell Differentiation Liver Development Embryonic Placenta Development Myeloid Progenitor Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II B Cell Differentiation T Cell Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Monocyte Differentiation Lung Development Granulocyte Differentiation Enucleate Erythrocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis Embryonic Skeletal System Development Embryonic Process Involved In Female Pregnancy Definitive Hemopoiesis
Pathways		HDACs deacetylate histones Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production	SUMOylation of transcription factors
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Appendicular lean mass ( 33097823) Axial length ( 24144296) Height ( 29782485) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Menarche (age at onset) ( 21102462 25231870) Mild age-related type 2 diabetes ( 34737425) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Triglyceride levels ( 32203549) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172)	Appendicular lean mass ( 33097823) End-stage renal disease in Type 1 diabetics ( 24029427) Lung cancer ( 28604730) Male-pattern baldness ( 27182965) Mosquito bite size ( 28199695) Otitis media (chronic/recurrent) ( 23974705) QT interval ( 24952745 29874175) Sensation seeking ( 30718321)
Interacting Genes		16 interacting genes: BANP EXOSC8 FHL2 FHL3 H3C14 HDAC1 HDAC2 HMG20B KDM1A KRT40 L3MBTL3 LPXN RCOR1 SP3 TRAF1 ZYX	30 interacting genes: AKT1 CIB3 E2F1 EP300 ESR1 GABPA GCH1 GRIN1 HDAC1 HDAC2 HLTF LIN54 MAP1LC3A NKX3-1 PHF21A PIAS1 POGZ RB1 RBBP4 RPS20 SNRPB SP1 SPANXN2 SUMO1 TP53 TP73 UBE2I VEGFA WHR1 ZBTB7A
Entrez ID		51317	6670
HPRD ID		10516	03483
Ensembl ID		ENSG00000135365	ENSG00000172845
Uniprot IDs		Q96BD5	B7ZLN9 Q02447 Q59FX5 Q86TP0
PDB IDs		2PUY 2YQL
Enriched GO Terms of Interacting Partners?		Chromatin Binding Chromatin Organization Protein Lysine Delactylase Activity Fungiform Papilla Formation Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Protein Decrotonylase Activity Histone Decrotonylase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Hair Follicle Placode Formation Histone Deacetylase Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Repressor Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Activity Negative Regulation Of Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Promoter-specific Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Lysine Deacetylase Activity Eyelid Development In Camera-type Eye Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides DNA Repair Complex Cell Differentiation NuRD Complex Nucleoplasm Histone Deacetylase Activity Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Oligodendrocyte Differentiation Sin3-type Complex Regulation Of Cell Fate Specification Regulation Of Chromatin Organization Negative Regulation Of Stem Cell Population Maintenance Histone Methyltransferase Complex Granulocyte Differentiation Cellular Developmental Process NF-kappaB Binding Enzyme Binding Regulation Of Androgen Receptor Signaling Pathway Focal Adhesion Regulation Of Intracellular Estrogen Receptor Signaling Pathway Nucleosomal DNA Binding Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Response To Stress DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Nucleoplasm Chromatin Regulation Of Primary Metabolic Process DNA Damage Response Regulation Of Gene Expression Transcription Coregulator Binding DNA Binding Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Macromolecule Metabolic Process Enzyme Binding Regulation Of Gliogenesis Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Biosynthetic Process Regulation Of Nervous System Development Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cell Development Response To Oxygen Levels Histone Deacetylase Binding Nucleus Chromatin Organization Response To Stress Regulation Of Neurogenesis Cellular Response To Decreased Oxygen Levels DNA Repair Negative Regulation Of Macromolecule Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Multicellular Organismal Process
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