RNF20 and KIF11

Number of citations of the paper that reports this interaction (PubMedID 27557628)
44

Data Source:
BioGRID (enzymatic study)

		RNF20	KIF11
Description		ring finger protein 20	kinesin family member 11
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Nucleolus HULC Complex	Spindle Pole Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Spindle Microtubule Membrane Protein-containing Complex Ciliary Basal Body Mitotic Spindle
	Molecular Function	P53 Binding Chromatin Binding Transcription Coactivator Activity MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H2B C-terminal K Residue Ubiquitin Ligase Activity	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity Protein Kinase Binding
	Biological Process	Protein Polyubiquitination Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Protein Ubiquitination Negative Regulation Of Cell Migration Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Mitotic Cell Cycle Microtubule-based Movement Spindle Organization Mitotic Spindle Organization Mitotic Centrosome Separation Regulation Of Mitotic Centrosome Separation Spindle Assembly Spindle Elongation Cell Division Mitotic Spindle Assembly Mitotic Nuclear Division
Pathways		E3 ubiquitin ligases ubiquitinate target proteins RHOBTB1 GTPase cycle	MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs			3-[(5s)-1-Acetyl-3-(2-Chlorophenyl)-4,5-Dihydro-1h-Pyrazol-5-Yl]Phenol Monastrol Filanesib (4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE N,N-DIETHYL-2-[(2-THIENYLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE (5R)-N,N-DIETHYL-5-METHYL-2-[(THIOPHEN-2-YLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE MK-0731 [(4R)-4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL](PHENYL)METHANONE (2S)-4-(2,5-DIFLUOROPHENYL)-N-METHYL-2-PHENYL-N-PIPERIDIN-4-YL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE (1S)-1-CYCLOPROPYL-2-[(2S)-4-(2,5-DIFLUOROPHENYL)-2-PHENYL-2,5-DIHYDRO-1H-PYRROL-1-YL]-2-OXOETHANAMINE (2S)-4-(2,5-DIFLUOROPHENYL)-N,N-DIMETHYL-2-PHENYL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE (5S)-5-(3-AMINOPROPYL)-3-(2,5-DIFLUOROPHENYL)-N-ETHYL-5-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE
Diseases
GWAS			Asthma ( 30929738 31619474 32296059) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Blood glucose levels ( 31928498) Inflammatory bowel disease ( 28067908) Insulin-related traits (multivariate analysis) ( 32002517) Intraocular pressure ( 29785010 30054594) Pancreatic beta-cell glucose sensitivity ( 32944759) Triglyceride levels ( 31928498) Type 2 diabetes ( 21490949 31118516)
Interacting Genes		41 interacting genes: AIRIM AMOTL2 ATM BAG4 CDC73 DIS3L EEF1D FBH1 FGFR4 H2AC18 H2AC20 H2AC4 H2BC21 H2BC3 H3C14 H4C14 HSF1 HTT ITSN2 KIF11 MSL1 NCBP1 PA2G4 PAF1 PRPF8 RAD51 RB1CC1 RBPMS RPA1 RPA2 SUMO2 TACC3 TRIM14 UBE2A UBE2B UBE2D2 UBE2E1 UBE2L3 USHBP1 XRCC3 ZDHHC17	12 interacting genes: AURKA CDK1 CEBPA DCTN1 ERCC1 ERCC4 PPARG RNF20 RNF40 SRPK2 SUMO2 UHRF1
Entrez ID		56254	3832
HPRD ID		07410	01023
Ensembl ID		ENSG00000155827	ENSG00000138160
Uniprot IDs		Q5VTR2	P52732
PDB IDs		5TRB 8GUI 8GUJ 8IEJ	1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2FME 2G1Q 2GM1 2IEH 2PG2 2Q2Y 2Q2Z 2UYI 2UYM 2WOG 2X2R 2X7C 2X7D 2X7E 2XAE 3CJO 3HQD 3K3B 3K5E 3KEN 3L9H 3WPN 3ZCW 4A1Z 4A28 4A50 4A51 4A5Y 4AP0 4AQV 4AQW 4AS7 4B7B 4BBG 4BXN 4CK5 4CK6 4CK7 4ZCA 4ZHI 5JV3 5ZO7 5ZO8 5ZO9 6G6Y 6G6Z 6HKX 6HKY 6TA3 6TA4 6TIW 6TLE 6TRL 6Y1I 8YHH
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Chromatin Chromosome, Telomeric Region Nucleus Nucleosome Ubiquitin Conjugating Enzyme Activity Nucleoplasm Chromosome Chromatin Organization Telomere Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Protein Heterodimerization Activity Chromatin Remodeling DNA Repair Telomere Maintenance Protein Localization To Chromosome PML Body Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Regulation Of Metabolic Process Ubiquitin-like Protein Transferase Activity Double-strand Break Repair Chromosome Organization DNA Recombination Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Cellular Response To Ionizing Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Cellular Response To Gamma Radiation Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Cell Cycle Process DNA Metabolic Process Protein Polyubiquitination DNA Binding Positive Regulation Of MRNA 3'-end Processing HULC Complex Nuclear Division MRNA 3'-end Processing DNA Damage Response Endodermal Cell Fate Commitment Protein-DNA Complex Assembly Site Of Double-strand Break Regulation Of Macromolecule Metabolic Process Cdc73/Paf1 Complex Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of DNA Metabolic Process Post-translational Protein Modification Meiotic Telomere Clustering	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Telomeric DNA-containing Double Minutes Formation Nucleotide-excision Repair Factor 1 Complex Negative Regulation Of Protection From Non-homologous End Joining At Telomere Positive Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Spindle ERCC4-ERCC1 Complex Negative Regulation Of Telomere Maintenance In Response To DNA Damage 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Nucleoplasm HULC Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleotide-excision Repair Complex Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Organelle Organization Negative Regulation Of Telomere Capping Regulation Of RNA Metabolic Process Chromatin Organization Spindle Regulation Of Mitotic Cell Cycle Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding Regulation Of Gene Expression Cilium Disassembly Regulation Of Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process STAT Family Protein Binding Regulation Of Macromolecule Biosynthetic Process UV Protection Macromolecule Metabolic Process Telomere Maintenance Via Recombination Regulation Of Telomere Capping Cellular Response To Stress Cilium Organization Nuclear Membrane Disassembly Nucleus Ubiquitin Protein Ligase Binding Membrane Disassembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
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