MYO10 and ACTA1

Number of citations of the paper that reports this interaction (PMID 10984435)
47

Data Source:
HPRD (in vivo)

		MYO10	ACTA1
Gene Name		myosin X	actin, alpha 1, skeletal muscle
Image
Gene Ontology Annotations	Cellular Component	Ruffle Nucleolus Cytoplasm Cytosol Plasma Membrane Cell Cortex Myosin Complex Lamellipodium Filopodium Membrane Filopodium Tip Neuron Projection Neuronal Cell Body	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Spectrin Binding Actin-dependent ATPase Activity Actin Filament Binding Plus-end Directed Microfilament Motor Activity	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding
	Biological Process	Axon Guidance Metabolic Process Regulation Of Cell Shape Positive Regulation Of Cell-cell Adhesion Cytoskeleton-dependent Intracellular Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Filopodium Assembly	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Cell Growth Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development
Pathways		Axon guidance Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Striated Muscle Contraction
Drugs
Diseases
GWAS		Major depressive disorder ( 23377640) Obesity-related traits ( 23251661) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		6 interactors: ACTA1 CALM1 CALML3 DYNLL1 ITGB5 PLA2G10	107 interactors: ABL1 ABRA ACTR10 ACTR1B ADSS AFAP1 AIF1 AJUBA AMOT CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		4651	58
HPRD ID		03283	00030
Ensembl ID		ENSG00000145555	ENSG00000143632
Uniprot IDs		E7EPL7 Q9HD67	P68133 Q5T8M7
PDB IDs		2LW9 3AU4 3AU5 3PZD	1T44
Enriched GO Terms of Interacting Partners?		Muscle Contraction Muscle System Process Substantia Nigra Development Neural Nucleus Development Midbrain Development Actin Cytoskeleton Organization Actin Filament-based Process Lysophospholipid Transport Actomyosin Structure Organization Positive Regulation Of Transport Multicellular Organismal Development Anatomical Structure Development Skeletal Muscle Fiber Adaptation Anatomical Structure Morphogenesis Developmental Process Positive Regulation Of Ion Transport Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Antigen Processing And Presentation Of Peptide Antigen Negative Regulation Of Cholesterol Efflux Regulation Of High Voltage-gated Calcium Channel Activity Cytoskeleton Organization Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Arachidonic Acid Secretion Skeletal Muscle Thin Filament Assembly Organelle Organization Antigen Processing And Presentation Regulation Of Arachidonic Acid Secretion Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Actin Filament Organization Skeletal Myofibril Assembly Response To Metal Ion Skeletal Muscle Adaptation Alcohol Metabolic Process Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Cholesterol Transport Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Transport Negative Regulation Of Phosphorylation Positive Regulation Of Phosphoprotein Phosphatase Activity Phosphatidylinositol Acyl-chain Remodeling Positive Regulation Of Prostaglandin Secretion Stress Fiber Assembly Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Regulation Of Intracellular Transport Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion	Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Actin Filament-based Movement Muscle Contraction Muscle System Process Cell Projection Organization Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Cellular Component Assembly Developmental Process Anatomical Structure Morphogenesis Anatomical Structure Development Negative Regulation Of Protein Complex Assembly System Development Actin-mediated Cell Contraction Response To Wounding Locomotion Cell Development Response To External Stimulus Cell Differentiation Wound Healing Multicellular Organismal Development Cell Morphogenesis Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Tissue Development Cell Projection Morphogenesis Chemotaxis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Neuron Development Actin Polymerization Or Depolymerization Blood Coagulation Hemostasis Cell Junction Assembly
Tagcloud ?		adenocarcinoma aggressive attenuated carcinomas dissemination driven ductal edges engines filopodia inducing integrin integrins invasion metastasis motor mutant myosin predominantly profiles promoted promoting protrusions serve sets specialized tip tp53 upregulation	annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40
Tagcloud (Difference) ?		adenocarcinoma aggressive attenuated carcinomas dissemination driven ductal edges engines filopodia inducing integrin integrins invasion metastasis motor mutant myosin predominantly profiles promoted promoting protrusions serve sets specialized tip tp53 upregulation	annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40
Tagcloud (Intersection) ?