MYO10 and ITGB5

Number of citations of the paper that reports this interaction (PMID 15156152)
62

Data Source:
HPRD (in vivo, two hybrid)

		MYO10	ITGB5
Gene Name		myosin X	integrin, beta 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleolus Cytoplasm Cytosol Plasma Membrane Cell Cortex Myosin Complex Lamellipodium Filopodium Membrane Filopodium Tip Neuron Projection Neuronal Cell Body	Plasma Membrane Focal Adhesion Cell Surface Cell Leading Edge Integrin Alphav-beta5 Complex Receptor Complex Phagocytic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Spectrin Binding Actin-dependent ATPase Activity Actin Filament Binding Plus-end Directed Microfilament Motor Activity	Receptor Activity Integrin Binding Protein Binding
	Biological Process	Axon Guidance Metabolic Process Regulation Of Cell Shape Positive Regulation Of Cell-cell Adhesion Cytoskeleton-dependent Intracellular Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Filopodium Assembly	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Muscle Contraction Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Extracellular Matrix Organization Endodermal Cell Differentiation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Stress Fiber Assembly Epithelial Cell-cell Adhesion
Pathways		Axon guidance Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Elastic fibre formation Smooth Muscle Contraction Non-integrin membrane-ECM interactions Molecules associated with elastic fibres Syndecan interactions ECM proteoglycans Integrin cell surface interactions Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS		Major depressive disorder ( 23377640) Obesity-related traits ( 23251661) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		6 interactors: ACTA1 CALM1 CALML3 DYNLL1 ITGB5 PLA2G10	34 interactors: ANXA5 CYR61 DAB1 DAB2 DOK1 EHMT2 EPS8 EWSR1 FHL2 FLNA GNB2L1 ITGA5 ITGAV ITGB3BP KRT40 KRTAP10-8 KRTAP10-9 LTBP1 LTBP3 MTUS2 MYO10 NOTCH2NL NUMB P2RY2 PAK4 PALLD PIAS2 PPARD PTK2 SNTA1 SRSF9 TLN1 TNS2 ZBTB17
Entrez ID		4651	3693
HPRD ID		03283	00949
Ensembl ID		ENSG00000145555	ENSG00000082781
Uniprot IDs		E7EPL7 Q9HD67	L7RT22 P18084
PDB IDs		2LW9 3AU4 3AU5 3PZD
Enriched GO Terms of Interacting Partners?		Muscle Contraction Muscle System Process Substantia Nigra Development Neural Nucleus Development Midbrain Development Actin Cytoskeleton Organization Actin Filament-based Process Lysophospholipid Transport Actomyosin Structure Organization Positive Regulation Of Transport Multicellular Organismal Development Anatomical Structure Development Skeletal Muscle Fiber Adaptation Anatomical Structure Morphogenesis Developmental Process Positive Regulation Of Ion Transport Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Antigen Processing And Presentation Of Peptide Antigen Negative Regulation Of Cholesterol Efflux Regulation Of High Voltage-gated Calcium Channel Activity Cytoskeleton Organization Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Arachidonic Acid Secretion Skeletal Muscle Thin Filament Assembly Organelle Organization Antigen Processing And Presentation Regulation Of Arachidonic Acid Secretion Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Actin Filament Organization Skeletal Myofibril Assembly Response To Metal Ion Skeletal Muscle Adaptation Alcohol Metabolic Process Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Cholesterol Transport Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Transport Negative Regulation Of Phosphorylation Positive Regulation Of Phosphoprotein Phosphatase Activity Phosphatidylinositol Acyl-chain Remodeling Positive Regulation Of Prostaglandin Secretion Stress Fiber Assembly Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Regulation Of Intracellular Transport Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion	Signaling Cell Communication Signal Transduction Regulation Of Cellular Process Cellular Response To Stimulus Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Locomotion Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Morphogenesis Response To Stimulus Regulation Of Cell Migration Wound Healing Cell Development Regulation Of Cell Motility Movement Of Cell Or Subcellular Component Regulation Of Locomotion Response To Wounding Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Death Positive Regulation Of Protein Phosphorylation Cell Differentiation Extracellular Matrix Organization Extracellular Structure Organization Cell Migration Regulation Of Apoptotic Process Cell Surface Receptor Signaling Pathway Chemotaxis Positive Regulation Of Phosphorylation Axon Guidance Multicellular Organismal Development Regulation Of Cell Adhesion Cell Motility Positive Regulation Of Protein Modification Process Regulation Of Cell Death Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Blood Coagulation Negative Regulation Of Programmed Cell Death Hemostasis Developmental Process Anatomical Structure Development Apoptotic Process Positive Regulation Of Protein Kinase Activity Programmed Cell Death Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Cell Morphogenesis
Tagcloud ?		adenocarcinoma aggressive attenuated carcinomas dissemination driven ductal edges engines filopodia inducing integrin integrins invasion metastasis motor mutant myosin predominantly profiles promoted promoting protrusions serve sets specialized tip tp53 upregulation	concurrently ctsk dc dendritic elucidated enhancer imply isoform itga2 itga5 itgav itgb1 itgb3 microphthalmia mitf multinucleated nfatc1 osteoclast osteoclastogenesis osteoclasts potentiated rankl raw264 resembled stamp tartrate tgf transforming transmembrane
Tagcloud (Difference) ?		adenocarcinoma aggressive attenuated carcinomas dissemination driven ductal edges engines filopodia inducing integrin integrins invasion metastasis motor mutant myosin predominantly profiles promoted promoting protrusions serve sets specialized tip tp53 upregulation	concurrently ctsk dc dendritic elucidated enhancer imply isoform itga2 itga5 itgav itgb1 itgb3 microphthalmia mitf multinucleated nfatc1 osteoclast osteoclastogenesis osteoclasts potentiated rankl raw264 resembled stamp tartrate tgf transforming transmembrane
Tagcloud (Intersection) ?