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MYO5A and DYNLL1
Number of citations of the paper that reports this interaction (PubMedID
10844022
)
56
Data Source:
HPRD
(in vivo, two hybrid, in vitro)
MYO5A
DYNLL1
Description
myosin VA
dynein light chain LC8-type 1
Image
GO Annotations
Cellular Component
Ruffle
Cytoplasm
Lysosome
Early Endosome
Late Endosome
Peroxisome
Endoplasmic Reticulum
Cytosol
Actin Filament
Actin Cytoskeleton
Membrane
Myosin Complex
Growth Cone
Cytoplasmic Vesicle
Vesicle
Filopodium Tip
Insulin-responsive Compartment
Melanosome
Neuron Projection
Recycling Endosome
Extracellular Exosome
Kinetochore
Nucleus
Chromosome
Cytoplasm
Mitochondrion
Centrosome
Cytosol
Cytoskeleton
Cytoplasmic Dynein Complex
Microtubule
Microtubule Associated Complex
Plasma Membrane
Cilium
COP9 Signalosome
Microtubule Cytoskeleton
Membrane
Secretory Granule
Dynein Complex
Site Of Double-strand Break
Tertiary Granule Membrane
Mitotic Spindle
Ciliary Tip
Ficolin-1-rich Granule Membrane
Axon Cytoplasm
Molecular Function
Microfilament Motor Activity
Nucleotide Binding
RNA Binding
Cytoskeletal Motor Activity
Actin Binding
Catalytic Activity
Protein Binding
Calmodulin Binding
ATP Binding
ATP Hydrolysis Activity
Small GTPase Binding
Actin Filament Binding
Enzyme Inhibitor Activity
Protein Binding
Enzyme Binding
Nitric-oxide Synthase Regulator Activity
Nitric-oxide Synthase Inhibitor Activity
Identical Protein Binding
Protein-containing Complex Binding
Dynein Intermediate Chain Binding
Deoxyribonuclease Inhibitor Activity
Scaffold Protein Binding
Biological Process
Post-Golgi Vesicle-mediated Transport
Endocytosis
Actin Filament Organization
Protein Transport
Vesicle-mediated Transport
Actin Filament-based Movement
Vesicle Transport Along Actin Filament
Melanosome Transport
Cellular Response To Insulin Stimulus
Protein Localization To Plasma Membrane
Regulation Of Golgi Organization
Apoptotic Process
DNA Damage Response
Microtubule-based Process
Spermatid Development
Substantia Nigra Development
Positive Regulation Of Intracellular Transport
Intraciliary Retrograde Transport
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Negative Regulation Of Phosphorylation
Motile Cilium Assembly
Negative Regulation Of Nitric Oxide Biosynthetic Process
DNA Strand Resection Involved In Replication Fork Processing
Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Regulation of actin dynamics for phagocytic cup formation
Insulin processing
FCGR3A-mediated phagocytosis
Regulation of MITF-M-dependent genes involved in pigmentation
Regulation of MITF-M-dependent genes involved in pigmentation
Activation of BIM and translocation to mitochondria
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Macroautophagy
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
Intraflagellar transport
RHO GTPases Activate Formins
Neutrophil degranulation
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
AURKA Activation by TPX2
HCMV Early Events
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS
Mean platelet volume (
32888494
)
Metabolite levels (Pyroglutamine) (
23934736
)
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
27863252
32888494
)
Immature fraction of reticulocytes (
27863252
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Reading disability or specific language impairment (pleiotropy) (
25065397
)
Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) (
25065397
)
Reticulocyte count (
27863252
32888494
)
Reticulocyte fraction of red cells (
27863252
32888494
)
Interacting Genes
20 interacting genes:
AKAP9
BMF
CALM1
DLGAP1
DYNLL1
DYNLL2
ERG
KIF5B
MLPH
NDEL1
NEFL
PDE4B
PRPH
RAB11A
RAB27A
RAB3A
RPH3A
TRIM2
TRIM3
USP7
108 interacting genes:
ACTB
ACTC1
ACTG1
ALDOA
AMOTL2
B3GALT4
BACH1
BCAS1
BCL2L11
BMF
C14orf119
C19orf44
CA2
CACNB1
CCDC28A
CIMAP1A
CLIP2
COXFA4L2
CS
DAZ1
DCTN5
DLG4
DLGAP1
DNAJB9
DNM2
DNM3
DNMT1
DPPA3
DYNC1H1
DYNC1I1
DYRK1A
EEF1A1
ERG28
FAM153A
FAM53B
GABARAPL1
GABARAPL2
GAPDH
GLUD1
GLUL
GNL3L
GPHN
GPRIN2
GRIN3A
HIP1R
HMBOX1
HOMER3
HSPA8
IHO1
INPP1
IQUB
KANK2
LDHA
MAP1B
MARK3
MAST2
ME2
MORC3
MORN3
MRE11
MTA1
MTR
MYO10
MYO5A
NDEL1
NFKBIA
NOS1
NRF1
NTRK1
NTRK2
NTRK3
OR7C2
OTUD6A
PAK1
PAN2
PARD3
PAX6
PCM1
PFKM
PFKP
PKIA
PKIB
PKIG
POLH
PPP3R2
RAB4A
RACK1
RASGRP4
REDIC1
RGS2
SHROOM3
SLC13A1
SMCP
TERT
THAP10
THAP8
TNFRSF14
TP53BP1
TRIM54
TSNARE1
TUBA3C
TUBB
TXNDC17
VIM
ZHX1
ZMYND11
ZNF354A
ZNF710
Entrez ID
4644
8655
HPRD ID
01179
03334
Ensembl ID
ENSG00000197535
ENSG00000088986
Uniprot IDs
A0A8I5KTF1
A0A8J8YWI7
A8CDT9
Q9UES4
Q9Y4I1
P63167
Q6FGH9
PDB IDs
4D07
4J5L
4LLI
4LX1
4LX2
5JCY
5JCZ
1CMI
3ZKE
3ZKF
6GZJ
6GZL
6RLB
6SC2
7D35
8PR0
8PR1
8PTK
8RGG
Enriched GO Terms of Interacting Partners
?
Establishment Of Vesicle Localization
Vesicle Localization
Establishment Of Organelle Localization
Organelle Localization
Axon Cytoplasm
Myosin V Binding
Establishment Of Localization In Cell
Retrograde Axonal Transport
Protein-containing Complex Binding
Establishment Of Melanosome Localization
Melanosome Localization
Melanosome Transport
Pigment Granule Transport
Pigment Granule Localization
Regulation Of Transport
Centrosome
Centrosome Localization
Exosomal Secretion
Synaptic Vesicle Transport
Microtubule Associated Complex
Synaptic Vesicle Membrane
Modulation Of Chemical Synaptic Transmission
Synaptic Vesicle
Microtubule-based Process
Positive Regulation Of Regulated Secretory Pathway
Lysosome Localization
Transport Along Microtubule
Vesicle
Axonal Transport
Neurofilament Cytoskeleton Organization
Microtubule-based Movement
Cytoskeleton-dependent Intracellular Transport
Cytosol
Microtubule-based Transport
Axo-dendritic Transport
Positive Regulation Of Exocytosis
Cytoskeleton
Organelle Transport Along Microtubule
Protein Transport
Vesicle-mediated Transport In Synapse
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Regulation Of Cellular Component Organization
Positive Regulation Of Cellular Component Organization
Organelle Organization
Secretory Granule
Regulation Of Intracellular Transport
Intracellular Transport
Regulation Of Cellular Localization
Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane
Cytoskeleton
Microtubule
Cytoplasm
Postsynaptic Density
Microtubule Binding
Neurotrophin Receptor Activity
Neurotrophin Binding
Cytosol
Pyruvate Metabolic Process
Neuron Projection Morphogenesis
Nucleotide Binding
Cell Projection Morphogenesis
Glycolytic Process
Fructose 1,6-bisphosphate Metabolic Process
Cytoskeleton Organization
Actin Filament
Identical Protein Binding
ADP Catabolic Process
Purine Ribonucleoside Diphosphate Catabolic Process
Microtubule-based Process
Apical Junction Complex
ADP Metabolic Process
Nucleoside Diphosphate Catabolic Process
Ribonucleoside Diphosphate Catabolic Process
Positive Regulation Of Cellular Component Biogenesis
Replication Fork
CAMP-dependent Protein Kinase Inhibitor Activity
Cytoskeleton-dependent Intracellular Transport
Dendritic Spine
Organelle Organization
Axon
Establishment Of Organelle Localization
Axonogenesis
Microtubule Associated Complex
Carbohydrate Catabolic Process
Peptidyl-cysteine S-nitrosylase Activity
6-phosphofructokinase Activity
6-phosphofructokinase Complex
Beta-tubulin Binding
Ribonucleoside Diphosphate Metabolic Process
Purine Ribonucleotide Catabolic Process
Microtubule Cytoskeleton Organization
Substantia Nigra Development
Negative Regulation Of Protein Import Into Nucleus
Myelination In Peripheral Nervous System
Regulation Of Transport
Nucleoside Diphosphate Metabolic Process
Regulation Of Transepithelial Transport
Calyx Of Held
Fructose-6-phosphate Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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