DYNLL1 and RASGRP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DYNLL1	RASGRP4
Description		dynein light chain LC8-type 1	RAS guanyl releasing protein 4
Image
GO Annotations	Cellular Component	Kinetochore Nucleus Chromosome Cytoplasm Mitochondrion Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Microtubule Associated Complex Plasma Membrane Cilium COP9 Signalosome Microtubule Cytoskeleton Membrane Secretory Granule Dynein Complex Site Of Double-strand Break Tertiary Granule Membrane Mitotic Spindle Ciliary Tip Ficolin-1-rich Granule Membrane Axon Cytoplasm	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Enzyme Binding Nitric-oxide Synthase Regulator Activity Nitric-oxide Synthase Inhibitor Activity Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Deoxyribonuclease Inhibitor Activity Scaffold Protein Binding	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Lipid Binding Diacylglycerol Binding GTPase Regulator Activity Metal Ion Binding
	Biological Process	Apoptotic Process DNA Damage Response Microtubule-based Process Spermatid Development Substantia Nigra Development Positive Regulation Of Intracellular Transport Intraciliary Retrograde Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Phosphorylation Motile Cilium Assembly Negative Regulation Of Nitric Oxide Biosynthetic Process DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing	Positive Regulation Of Natural Killer Cell Mediated Immunity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Myeloid Cell Differentiation Cell Differentiation Antibacterial Innate Immune Response
Pathways		Activation of BIM and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	FCERI mediated NF-kB activation RAF/MAP kinase cascade
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 27863252 32888494) Monocyte count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		108 interacting genes: ACTB ACTC1 ACTG1 ALDOA AMOTL2 B3GALT4 BACH1 BCAS1 BCL2L11 BMF C14orf119 C19orf44 CA2 CACNB1 CCDC28A CIMAP1A CLIP2 COXFA4L2 CS DAZ1 DCTN5 DLG4 DLGAP1 DNAJB9 DNM2 DNM3 DNMT1 DPPA3 DYNC1H1 DYNC1I1 DYRK1A EEF1A1 ERG28 FAM153A FAM53B GABARAPL1 GABARAPL2 GAPDH GLUD1 GLUL GNL3L GPHN GPRIN2 GRIN3A HIP1R HMBOX1 HOMER3 HSPA8 IHO1 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MORC3 MORN3 MRE11 MTA1 MTR MYO10 MYO5A NDEL1 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 OR7C2 OTUD6A PAK1 PAN2 PARD3 PAX6 PCM1 PFKM PFKP PKIA PKIB PKIG POLH PPP3R2 RAB4A RACK1 RASGRP4 REDIC1 RGS2 SHROOM3 SLC13A1 SMCP TERT THAP10 THAP8 TNFRSF14 TP53BP1 TRIM54 TSNARE1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A ZNF710	6 interacting genes: BNIP2 DYNLL1 HRAS RAP1A SEC22A TMPRSS4
Entrez ID		8655	115727
HPRD ID		03334	09540
Ensembl ID		ENSG00000088986	ENSG00000171777
Uniprot IDs		P63167 Q6FGH9	Q8TDF6
PDB IDs		1CMI 3ZKE 3ZKF 6GZJ 6GZL 6RLB 6SC2 7D35 8PR0 8PR1 8PTK 8RGG	6AXG
Enriched GO Terms of Interacting Partners?		Cytoskeleton Microtubule Cytoplasm Postsynaptic Density Microtubule Binding Neurotrophin Receptor Activity Neurotrophin Binding Cytosol Pyruvate Metabolic Process Neuron Projection Morphogenesis Nucleotide Binding Cell Projection Morphogenesis Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Cytoskeleton Organization Actin Filament Identical Protein Binding ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Microtubule-based Process Apical Junction Complex ADP Metabolic Process Nucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Catabolic Process Positive Regulation Of Cellular Component Biogenesis Replication Fork CAMP-dependent Protein Kinase Inhibitor Activity Cytoskeleton-dependent Intracellular Transport Dendritic Spine Organelle Organization Axon Establishment Of Organelle Localization Axonogenesis Microtubule Associated Complex Carbohydrate Catabolic Process Peptidyl-cysteine S-nitrosylase Activity 6-phosphofructokinase Activity 6-phosphofructokinase Complex Beta-tubulin Binding Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Microtubule Cytoskeleton Organization Substantia Nigra Development Negative Regulation Of Protein Import Into Nucleus Myelination In Peripheral Nervous System Regulation Of Transport Nucleoside Diphosphate Metabolic Process Regulation Of Transepithelial Transport Calyx Of Held Fructose-6-phosphate Binding	Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of MAPK Cascade GDP Binding G Protein Activity Negative Regulation Of Growth Rate Regulation Of Cellular Localization GTPase Complex Response To Antineoplastic Agent Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Secretory Granule Regulation Of MAPK Cascade Phospholipase C Activator Activity Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Perinuclear Region Of Cytoplasm Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Localization To Membrane Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Growth Rate Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Synaptic Vesicle Exocytosis Apoptotic Process Oncogene-induced Cell Senescence Cell Development Guanyl-nucleotide Exchange Factor Complex Cell Death Programmed Cell Death Regulation Of Protein Localization Nitric-oxide Synthase Regulator Activity Positive Regulation Of Intracellular Signal Transduction Spindle Pole Centrosome Response To Oxygen-glucose Deprivation GTPase Activity Regulation Of ERK1 And ERK2 Cascade Vesicle-mediated Transport Positive Regulation Of Ruffle Assembly Small GTPase-mediated Signal Transduction T-helper 1 Type Immune Response Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Collagen Biosynthetic Process Cellular Response To Forskolin Rap Protein Signal Transduction Positive Regulation Of Vasculogenesis Nerve Growth Factor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?