DYNLL1 and GRIN3A

Number of citations of the paper that reports this interaction (PubMedID 14760703)
0

Data Source:
HPRD (in vitro)

		DYNLL1	GRIN3A
Description		dynein light chain LC8-type 1	glutamate ionotropic receptor NMDA type subunit 3A
Image
GO Annotations	Cellular Component	Kinetochore Nucleus Chromosome Cytoplasm Mitochondrion Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Microtubule Associated Complex Plasma Membrane Cilium COP9 Signalosome Microtubule Cytoskeleton Membrane Secretory Granule Dynein Complex Site Of Double-strand Break Tertiary Granule Membrane Mitotic Spindle Ciliary Tip Ficolin-1-rich Granule Membrane Axon Cytoplasm	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Monoatomic Ion Channel Complex Neuron Projection Neuronal Cell Body Organelle Synapse Postsynaptic Membrane Presynapse Postsynaptic Density Membrane Neurotransmitter Receptor Complex Glutamatergic Synapse
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Enzyme Binding Nitric-oxide Synthase Regulator Activity Nitric-oxide Synthase Inhibitor Activity Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Deoxyribonuclease Inhibitor Activity Scaffold Protein Binding	Glutamate-gated Receptor Activity NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Calcium Channel Activity Protein Binding Glutamate Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Glycine Binding Transmitter-gated Monoatomic Ion Channel Activity Signaling Receptor Activity Identical Protein Binding Protein Phosphatase 2A Binding Serine Binding Glycine-gated Cation Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Apoptotic Process DNA Damage Response Microtubule-based Process Spermatid Development Substantia Nigra Development Positive Regulation Of Intracellular Transport Intraciliary Retrograde Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Phosphorylation Motile Cilium Assembly Negative Regulation Of Nitric Oxide Biosynthetic Process DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing	Monoatomic Ion Transport Calcium Ion Transport Dendrite Development Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Response To Ethanol Regulation Of Synaptic Plasticity Rhythmic Process Neuron Development Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Prepulse Inhibition Negative Regulation Of Dendritic Spine Development Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		Activation of BIM and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors
Drugs			Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Profenamine Secobarbital Dextromethorphan Dextropropoxyphene Acamprosate Procaine Donepezil Guaifenesin Ethanol Amantadine Memantine Halothane Orphenadrine Phenobarbital Ketamine Aripiprazole Tenocyclidine Rolicyclidine Prasterone Phencyclidine Milnacipran Neramexane Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS		High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Alzheimer disease and age of onset ( 26830138) Asthma ( 27611488) Coronary artery aneurysm in Kawasaki disease ( 26434682) Coronary artery calcification ( 23870195) Glucocorticoid-induced osteonecrosis ( 26265699) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Glucocorticoid-induced osteonecrosis (time dependent analysis) ( 26265699) Obesity-related traits ( 23251661) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma anti-thyroglobulin levels ( 29678681) Plasma anti-thyroid peroxidase levels ( 29678681) Response to fenofibrate (triglyceride levels) ( 27002377) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		108 interacting genes: ACTB ACTC1 ACTG1 ALDOA AMOTL2 B3GALT4 BACH1 BCAS1 BCL2L11 BMF C14orf119 C19orf44 CA2 CACNB1 CCDC28A CIMAP1A CLIP2 COXFA4L2 CS DAZ1 DCTN5 DLG4 DLGAP1 DNAJB9 DNM2 DNM3 DNMT1 DPPA3 DYNC1H1 DYNC1I1 DYRK1A EEF1A1 ERG28 FAM153A FAM53B GABARAPL1 GABARAPL2 GAPDH GLUD1 GLUL GNL3L GPHN GPRIN2 GRIN3A HIP1R HMBOX1 HOMER3 HSPA8 IHO1 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MORC3 MORN3 MRE11 MTA1 MTR MYO10 MYO5A NDEL1 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 OR7C2 OTUD6A PAK1 PAN2 PARD3 PAX6 PCM1 PFKM PFKP PKIA PKIB PKIG POLH PPP3R2 RAB4A RACK1 RASGRP4 REDIC1 RGS2 SHROOM3 SLC13A1 SMCP TERT THAP10 THAP8 TNFRSF14 TP53BP1 TRIM54 TSNARE1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A ZNF710	6 interacting genes: DLG4 DYNLL1 GRIN1 GRIN2A GRIN2B PTPA
Entrez ID		8655	116443
HPRD ID		03334	09443
Ensembl ID		ENSG00000088986	ENSG00000198785
Uniprot IDs		P63167 Q6FGH9	Q8TCU5
PDB IDs		1CMI 3ZKE 3ZKF 6GZJ 6GZL 6RLB 6SC2 7D35 8PR0 8PR1 8PTK 8RGG	8USW 8USX 8UUE
Enriched GO Terms of Interacting Partners?		Cytoskeleton Microtubule Cytoplasm Postsynaptic Density Microtubule Binding Neurotrophin Receptor Activity Neurotrophin Binding Cytosol Pyruvate Metabolic Process Neuron Projection Morphogenesis Nucleotide Binding Cell Projection Morphogenesis Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Cytoskeleton Organization Actin Filament Identical Protein Binding ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Microtubule-based Process Apical Junction Complex ADP Metabolic Process Nucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Catabolic Process Positive Regulation Of Cellular Component Biogenesis Replication Fork CAMP-dependent Protein Kinase Inhibitor Activity Cytoskeleton-dependent Intracellular Transport Dendritic Spine Organelle Organization Axon Establishment Of Organelle Localization Axonogenesis Microtubule Associated Complex Carbohydrate Catabolic Process Peptidyl-cysteine S-nitrosylase Activity 6-phosphofructokinase Activity 6-phosphofructokinase Complex Beta-tubulin Binding Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Microtubule Cytoskeleton Organization Substantia Nigra Development Negative Regulation Of Protein Import Into Nucleus Myelination In Peripheral Nervous System Regulation Of Transport Nucleoside Diphosphate Metabolic Process Regulation Of Transepithelial Transport Calyx Of Held Fructose-6-phosphate Binding	Positive Regulation Of Excitatory Postsynaptic Potential Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Glutamate Receptor Signaling Pathway Modulation Of Excitatory Postsynaptic Potential NMDA Glutamate Receptor Activity Regulation Of Neuronal Synaptic Plasticity NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Synaptic Membrane Excitatory Chemical Synaptic Transmission Postsynaptic Density Membrane Regulation Of Nervous System Process Positive Regulation Of Synaptic Transmission Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Postsynaptic Membrane Postsynaptic Density Learning Or Memory Excitatory Postsynaptic Potential Cognition Chemical Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Neuron Projection Trans-synaptic Signaling Glutamate Binding Synaptic Signaling Amyloid-beta Binding Calcium Ion Transmembrane Import Into Cytosol Regulation Of Postsynaptic Membrane Potential Glycine Binding Regulation Of Membrane Potential Response To Ethanol Synaptic Vesicle Modulation Of Chemical Synaptic Transmission Protein Heterotetramerization Dendritic Spine Learning Regulation Of System Process Monoatomic Ion Channel Activity Calcium-mediated Signaling Cell-cell Signaling Signaling Calcium Ion Transmembrane Transport Cell Communication Regulation Of Transport Protein Heterooligomerization Excitatory Synapse Brain Development
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