DYNLL1 and DNM3

Number of citations of the paper that reports this interaction (PMID 14760703)
24

Data Source:
HPRD (in vitro)

		DYNLL1	DNM3
Gene Name		dynein, light chain, LC8-type 1	dynamin 3
Image
Gene Ontology Annotations	Cellular Component	Kinetochore Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane COP9 Signalosome Membrane Extracellular Vesicular Exosome Primary Cilium Mitotic Spindle Ciliary Tip	Mitochondrion Microtubule Postsynaptic Density Dendritic Spine Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Motor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Nitric-oxide Synthase Regulator Activity Protein Homodimerization Activity	GTPase Activity Protein Binding GTP Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transport Apoptotic Process Organelle Organization Microtubule-based Process Female Gamete Generation Anatomical Structure Morphogenesis Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Substantia Nigra Development Actin Cytoskeleton Organization Negative Regulation Of Phosphorylation Regulation Of Catalytic Activity Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Endocytosis Synapse Assembly Metabolic Process Filopodium Assembly
Pathways		Organelle biogenesis and maintenance Activation of BH3-only proteins Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Intraflagellar transport Loss of proteins required for interphase microtubule organizationÂ from the centrosome Activation of BIM and translocation to mitochondria Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Programmed Cell Death Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System Intrinsic Pathway for Apoptosis	Retrograde neurotrophin signalling Signalling by NGF Axon guidance L1CAM interactions NGF signalling via TRKA from the plasma membrane Recycling pathway of L1 Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade MHC class II antigen presentation Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS			Bone mineral density ( 22504420) Height ( 20881960 23563607 18391951) Mean platelet volume ( 22139419 19820697) Platelet counts ( 22139419) Waist-hip ratio ( 20935629)
Protein-Protein Interactions		77 interactors: ACTB ACTC1 ACTG1 ALDOA AMBRA1 AMOTL2 B3GALT4 BCAS1 BCL2L11 BMF C14orf1 CA2 CACNB1 CCDC36 CLIP2 CS DAZ1 DLG4 DLGAP1 DNAJB9 DNM2 DNM3 DNMT1 DYNC1H1 DYNC1I1 EEF1A1 GAPDH GLUD1 GLUL GNB2L1 GPHN GRIN3A HIP1R HSPA8 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MTA1 MTR MYO10 MYO5A NDUFA4L2 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 PAK1 PAN2 PARD3 PAX6 PFKM PFKP PKIA PKIB PKIG POLH RAB4A RGS2 SHROOM3 TERT THAP8 TNFRSF14 TP53BP1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A	2 interactors: DYNLL1 HOMER1
Entrez ID		8655	26052
HPRD ID		03334	13241
Ensembl ID		ENSG00000088986	ENSG00000197959
Uniprot IDs		P63167 Q6FGH9	Q6P2G1 Q9UQ16
PDB IDs		1CMI 3ZKE 3ZKF	3L43
Enriched GO Terms of Interacting Partners?		Nervous System Development Movement Of Cell Or Subcellular Component Cell Differentiation Developmental Process Regulation Of Cellular Component Organization Response To Organic Substance Regulation Of Cellular Localization Neuron Projection Morphogenesis Axonogenesis Cellular Response To Stimulus Synapse Organization Neuron Projection Development Neuron Development Regulation Of Cellular Protein Metabolic Process Response To Stimulus Neuron Differentiation Regulation Of Protein Metabolic Process Axon Development Cell Projection Morphogenesis Response To External Stimulus Anatomical Structure Morphogenesis Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Cell Part Morphogenesis Cellular Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Protein Homooligomerization Cell Morphogenesis Axon Guidance Negative Regulation Of Phosphorylation Regulation Of Cellular Process Glycolytic Process Locomotion Cell Development Negative Regulation Of Protein Phosphorylation Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Membrane Organization Regulation Of CAMP-dependent Protein Kinase Activity Cell Morphogenesis Involved In Differentiation Anatomical Structure Development Generation Of Neurons System Development Response To Stress Regulation Of Protein Phosphorylation Multicellular Organismal Development Neuromuscular Junction Development Pyruvate Metabolic Process Actin Filament-based Process	Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Positive Regulation Of Transport Chemical Homeostasis Within A Tissue Behavioral Response To Cocaine Regulation Of Store-operated Calcium Entry G-protein Coupled Glutamate Receptor Signaling Pathway Protein Localization To Synapse Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Calcium Ion Import Skeletal Muscle Fiber Development Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Skeletal Muscle Contraction Myotube Cell Development Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Substantia Nigra Development Response To Nicotine Musculoskeletal Movement Muscle Fiber Development Response To Cocaine Neural Nucleus Development Positive Regulation Of Mitochondrion Organization Myotube Differentiation Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Regulation Of Cation Channel Activity Striated Muscle Contraction Midbrain Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Calcium Ion Transport Response To Ammonium Ion Regulation Of Mitochondrion Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Female Gamete Generation Response To Calcium Ion G2/M Transition Of Mitotic Cell Cycle Skeletal Muscle Tissue Development Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Response To Alkaloid Skeletal Muscle Organ Development Striated Muscle Cell Development Regulation Of Signal Transduction Adult Behavior Muscle Cell Development Circadian Rhythm
Tagcloud ?		1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating	1q24 200k aaa adventitial aneurysm aortic atherosclerosis atherosclerotic c1orf105 carotid cimt cohorts compensatory determinants enlargement expansive forward iccad illumina intima metabochip pigc pooling proxy q remodelling rs3768445 rs4916251 snp
Tagcloud (Difference) ?		1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating	1q24 200k aaa adventitial aneurysm aortic atherosclerosis atherosclerotic c1orf105 carotid cimt cohorts compensatory determinants enlargement expansive forward iccad illumina intima metabochip pigc pooling proxy q remodelling rs3768445 rs4916251 snp
Tagcloud (Intersection) ?