DYNLL1 and NOS1

Number of citations of the paper that reports this interaction (PubMedID 9808772)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		DYNLL1	NOS1
Description		dynein light chain LC8-type 1	nitric oxide synthase 1
Image
GO Annotations	Cellular Component	Kinetochore Nucleus Chromosome Cytoplasm Mitochondrion Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Microtubule Associated Complex Plasma Membrane Cilium COP9 Signalosome Microtubule Cytoskeleton Membrane Secretory Granule Dynein Complex Site Of Double-strand Break Tertiary Granule Membrane Mitotic Spindle Ciliary Tip Ficolin-1-rich Granule Membrane Axon Cytoplasm	Photoreceptor Inner Segment Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Caveola Endomembrane System Postsynaptic Density Membrane Sarcoplasmic Reticulum Z Disc T-tubule Protein-containing Complex Sarcoplasmic Reticulum Membrane Sarcolemma Cell Projection Dendritic Spine Calyx Of Held Membrane Raft Synapse Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Enzyme Binding Nitric-oxide Synthase Regulator Activity Nitric-oxide Synthase Inhibitor Activity Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Deoxyribonuclease Inhibitor Activity Scaffold Protein Binding	Nitric-oxide Synthase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Sodium Channel Regulator Activity Heme Binding Tetrahydrobiopterin Binding Arginine Binding Peptidyl-cysteine S-nitrosylase Activity Transmembrane Transporter Binding Cadmium Ion Binding Metal Ion Binding Calcium-dependent Protein Binding Flavin Adenine Dinucleotide Binding NADP Binding Scaffold Protein Binding
	Biological Process	Apoptotic Process DNA Damage Response Microtubule-based Process Spermatid Development Substantia Nigra Development Positive Regulation Of Intracellular Transport Intraciliary Retrograde Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Phosphorylation Motile Cilium Assembly Negative Regulation Of Nitric Oxide Biosynthetic Process DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing	Response To Hypoxia Regulation Of Sodium Ion Transport L-arginine Catabolic Process Nitric Oxide Biosynthetic Process Potassium Ion Transport Calcium Ion Transport Striated Muscle Contraction Cell Communication Nitric Oxide Mediated Signal Transduction Myoblast Fusion Blood Circulation Response To Heat Response To Hormone Negative Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Metal Ion Transport Signaling Response To Lipopolysaccharide Multicellular Organismal Response To Stress Xenobiotic Catabolic Process Vasodilation Negative Regulation Of Potassium Ion Transport Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Neuron Apoptotic Process Cell Redox Homeostasis Negative Regulation Of Blood Pressure Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Negative Regulation Of Serotonin Uptake Establishment Of Localization In Cell Negative Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Postsynaptic Membrane Potential Regulation Of Biological Quality Cellular Response To Growth Factor Stimulus Positive Regulation Of The Force Of Heart Contraction Synaptic Signaling By Nitric Oxide Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Blood Circulation Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential
Pathways		Activation of BIM and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	ROS and RNS production in phagocytes Nitric oxide stimulates guanylate cyclase Ion homeostasis
Drugs			Citrulline Donepezil Ketamine L-N(omega)-Nitroarginine-2,4-L-diaminobutyric amide Formic acid 3-Bromo-7-Nitroindazole N-{(4S)-4-Amino-5-[(2-aminoethyl)amino]pentyl}-N'-nitroguanidine N-[3-(aminomethyl)benzyl]acetamidine L-N(omega)-nitroarginine-(4R)-amino-L-proline amide 1-hydroxy-2-isopropylguanidine 7-Nitroindazole N-omega-propyl-L-arginine 2-butyl-1-hydroxyguanidine S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine Flavin adenine dinucleotide Flavin mononucleotide N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide Nicotinamide adenine dinucleotide phosphate S-Ethyl-N-Phenyl-Isothiourea [(1S)-4-(1-Aminobutylideneamino)-1-carboxybutyl]azanium 5-N-Allyl-arginine Nitroarginine NXN-188 N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine Methylene blue
Diseases
GWAS		High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Anxiety ( 33859377) Baseline cortisol levels in response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Depression ( 33859377) Disability (impaired activities of daily living) ( 31707593) General factor of neuroticism ( 30867560) Neuroticism ( 29255261) Schizophrenia ( 28991256 30285260)
Interacting Genes		108 interacting genes: ACTB ACTC1 ACTG1 ALDOA AMOTL2 B3GALT4 BACH1 BCAS1 BCL2L11 BMF C14orf119 C19orf44 CA2 CACNB1 CCDC28A CIMAP1A CLIP2 COXFA4L2 CS DAZ1 DCTN5 DLG4 DLGAP1 DNAJB9 DNM2 DNM3 DNMT1 DPPA3 DYNC1H1 DYNC1I1 DYRK1A EEF1A1 ERG28 FAM153A FAM53B GABARAPL1 GABARAPL2 GAPDH GLUD1 GLUL GNL3L GPHN GPRIN2 GRIN3A HIP1R HMBOX1 HOMER3 HSPA8 IHO1 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MORC3 MORN3 MRE11 MTA1 MTR MYO10 MYO5A NDEL1 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 OR7C2 OTUD6A PAK1 PAN2 PARD3 PAX6 PCM1 PFKM PFKP PKIA PKIB PKIG POLH PPP3R2 RAB4A RACK1 RASGRP4 REDIC1 RGS2 SHROOM3 SLC13A1 SMCP TERT THAP10 THAP8 TNFRSF14 TP53BP1 TRIM54 TSNARE1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A ZNF710	33 interacting genes: ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ARG1 ATP2B4 BDKRB2 CAMK1 CAMK2A CAMK4 CAV3 CTBP1 DLG2 DLG4 DLGAP2 DYNLL1 HMOX1 HSP90AA1 NOS1AP NOSIP PFKM PRKACA PRKCA PRKD1 PTPN6 PTPRN RASD1 SNTA1 STUB1 SYN1 VAC14 ZDHHC23
Entrez ID		8655	4842
HPRD ID		03334	01226
Ensembl ID		ENSG00000088986	ENSG00000089250
Uniprot IDs		P63167 Q6FGH9	A0PJJ7 B3VK56 B4DG68 P29475
PDB IDs		1CMI 3ZKE 3ZKF 6GZJ 6GZL 6RLB 6SC2 7D35 8PR0 8PR1 8PTK 8RGG	4D1N 4UCH 4UH5 4UH6 4V3U 5ADF 5ADG 5ADI 5FVU 5FVV 5FVW 5FVX 5UO1 5UO2 5UO3 5UO4 5UO5 5UO6 5UO7 5VUV 5VUW 5VUX 5VUY 5VUZ 5VV0 5VV1 5VV2 5VV3 5VV4 5VV5 6AUY 6AUZ 6AV0 6AV1 6AV2 6AV3 6AV4 6AV5 6CIC 6CID 6NG1 6NG2 6NG4 6NG5 6NG6 6NG7 6NG8 6NGA 6NGB 6NGC 6NGD 6NGE 6NGF 6NGH 6NGI 6NHB 6NHC 6PNA 6PNB 6PNC 6PND 6PNE 6PNF 6PNG 6PNH 6PO5 6PO7 6PO8 6PO9 6POA 6POB 6POC 6POT 7TS1 7TS2 7TS3 7TS4 7TS5 7TS6 7TS7 7TS8 7UAM 7US7 7US8 8BI8 8BI9 8FGF 8FGG 8FGH 8FGI 8FGJ 8FGK 8FGL 8FGM 8UFP 8UFQ
Enriched GO Terms of Interacting Partners?		Cytoskeleton Microtubule Cytoplasm Postsynaptic Density Microtubule Binding Neurotrophin Receptor Activity Neurotrophin Binding Cytosol Pyruvate Metabolic Process Neuron Projection Morphogenesis Nucleotide Binding Cell Projection Morphogenesis Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Cytoskeleton Organization Actin Filament Identical Protein Binding ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Microtubule-based Process Apical Junction Complex ADP Metabolic Process Nucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Catabolic Process Positive Regulation Of Cellular Component Biogenesis Replication Fork CAMP-dependent Protein Kinase Inhibitor Activity Cytoskeleton-dependent Intracellular Transport Dendritic Spine Organelle Organization Axon Establishment Of Organelle Localization Axonogenesis Microtubule Associated Complex Carbohydrate Catabolic Process Peptidyl-cysteine S-nitrosylase Activity 6-phosphofructokinase Activity 6-phosphofructokinase Complex Beta-tubulin Binding Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Microtubule Cytoskeleton Organization Substantia Nigra Development Negative Regulation Of Protein Import Into Nucleus Myelination In Peripheral Nervous System Regulation Of Transport Nucleoside Diphosphate Metabolic Process Regulation Of Transepithelial Transport Calyx Of Held Fructose-6-phosphate Binding	Regulation Of System Process Regulation Of Blood Circulation Adrenergic Receptor Activity Regulation Of Muscle System Process Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Biological Quality Regulation Of Transport Regulation Of Heart Contraction Adrenergic Receptor Signaling Pathway Regulation Of Muscle Contraction System Process Nitric-oxide Synthase Binding Alpha1-adrenergic Receptor Activity Regulation Of Tube Size Blood Vessel Diameter Maintenance Regulation Of Metal Ion Transport Muscle System Process Vascular Process In Circulatory System Regulation Of Striated Muscle Contraction Phosphorylation Regulation Of Heart Rate Regulation Of Multicellular Organismal Process Neuron-glial Cell Signaling Regulation Of Monoatomic Ion Transport Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Circulatory System Process Regulation Of Vasoconstriction Regulation Of Nitric Oxide Metabolic Process G Protein-coupled Receptor Signaling Pathway Regulation Of Cardiac Muscle Hypertrophy Caveola Protein Phosphorylation Nitric-oxide Synthase Regulator Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Temperature Stimulus Neuromuscular Junction Positive Regulation Of Protein Transport Regulation Of Cardiac Muscle Contraction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Monoatomic Cation Transmembrane Transport Response To Cold Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Protein Localization Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Peptide Hormone Secretion Muscle Contraction Positive Regulation Of Cell Communication Positive Regulation Of Signaling
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