MYO5A and RAB27A

Number of citations of the paper that reports this interaction (PMID 12006666)
36

Data Source:
HPRD (in vitro, in vivo)

		MYO5A	RAB27A
Gene Name		myosin VA (heavy chain 12, myoxin)	RAB27A, member RAS oncogene family
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Photoreceptor Outer Segment Cytoplasm Lysosome Early Endosome Late Endosome Peroxisome Endoplasmic Reticulum Golgi Apparatus Cytosol Intermediate Filament Actin Filament Membrane Myosin Complex Growth Cone Vesicle Filopodium Tip Insulin-responsive Compartment Microtubule Plus-end Melanosome Actomyosin Neuron Projection Neuronal Cell Body Recycling Endosome Extracellular Vesicular Exosome	Photoreceptor Outer Segment Lysosome Late Endosome Golgi Apparatus Apical Plasma Membrane Secretory Granule Dendrite Secretory Granule Membrane Multivesicular Body Membrane Melanosome Extracellular Vesicular Exosome Exocytic Vesicle
	Molecular Function	Microfilament Motor Activity Actin Binding Calcium Ion Binding Calmodulin Binding ATP Binding Rab GTPase Binding Poly(A) RNA Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Transport Exocytosis Post-Golgi Vesicle-mediated Transport Synaptic Transmission Visual Perception Protein Transport Vesicle-mediated Transport Actin Filament-based Movement Vesicle Transport Along Actin Filament Insulin Secretion Melanocyte Differentiation Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Locomotion Involved In Locomotory Behavior Secretory Granule Localization Melanosome Transport Cellular Response To Insulin Stimulus Melanin Biosynthetic Process Odontogenesis Myelination Long-chain Fatty Acid Biosynthetic Process Cellular Protein Metabolic Process Synapse Organization Endoplasmic Reticulum Localization Membrane Organization Protein Localization To Plasma Membrane Regulation Of Golgi Organization	Protein Targeting Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Blood Coagulation Protein Secretion Positive Regulation Of Gene Expression Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Rab Protein Signal Transduction Multivesicular Body Organization Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Cellular Protein Metabolic Process Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion
Pathways		Peptide hormone metabolism Translocation of GLUT4 to the plasma membrane Insulin processing Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Peptide hormone metabolism Insulin processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: BMF DLGAP1 DYNLL1 DYNLL2 MLPH NEFL PRPH RAB11A RAB27A TRIM2 TRIM3	28 interactors: ADRB2 APP C14orf1 COPS6 EEF1A1 EXPH5 GDF9 GDI1 GZMB KIAA1377 LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16
Entrez ID		4644	5873
HPRD ID		01179	04845
Ensembl ID		ENSG00000197535	ENSG00000069974
Uniprot IDs		A8CDT9 F8WE88 G3V394 Q9UES4 Q9Y4I1	A2RU94 P51159
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Multivesicular Body Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Melanosome Localization Exosomal Secretion Cellular Pigmentation Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Pigmentation Intrinsic Apoptotic Signaling Pathway Melanosome Transport Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Endosome Organization Pigment Granule Transport Vesicle Localization Establishment Of Melanosome Localization Melanocyte Differentiation Positive Regulation Of Intracellular Transport Intermediate Filament Cytoskeleton Organization Neuroepithelial Cell Differentiation Intermediate Filament-based Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Antigen Processing And Presentation Regulation Of Apoptotic Process Anatomical Structure Development Microtubule-based Process Regulation Of Protein Localization Rab Protein Signal Transduction Developmental Pigmentation Regulation Of Cell Death Apoptotic Signaling Pathway Positive Regulation Of Constitutive Secretory Pathway Multivesicular Body Assembly Regulation Of Multivesicular Body Size Complement-dependent Cytotoxicity Synaptic Target Recognition Positive Regulation Of Axonogenesis Developmental Process Positive Regulation Of Organelle Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Organelle Localization Intracellular Signal Transduction Regulation Of Cellular Localization Regulation Of Intracellular Transport Cytotoxic T Cell Degranulation Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II	Exocytosis Secretion By Cell Intracellular Transport Secretion Cellular Protein Localization Establishment Of Localization In Cell Cellular Localization Protein Transport Intracellular Protein Transport Establishment Of Protein Localization Protein Localization Vesicle-mediated Transport Regulation Of Secretion Regulation Of Cellular Localization Regulation Of Exocytosis Positive Regulation Of Secretion Transport Positive Regulation Of Exocytosis Positive Regulation Of Transport Regulation Of Vesicle-mediated Transport Regulation Of Establishment Of Protein Localization Multivesicular Body Sorting Pathway Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Membrane Potential Calcium Ion-dependent Exocytosis Regulation Of Protein Localization Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Protein Transport Positive Regulation Of Protein Secretion Regulation Of Protein Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Vesicle Localization Regulation Of Postsynaptic Membrane Potential Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Hormone Secretion Neurotransmitter Secretion Regulation Of Signaling Membrane Depolarization Glutamate Secretion Positive Regulation Of Protein Transport Regulation Of Neurotransmitter Levels Membrane Hyperpolarization Melanocyte Differentiation Neurotransmitter Transport Melanosome Localization Visual Perception Sensory Perception Of Light Stimulus Insulin Secretion Organelle Localization
Tagcloud ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	adenocarcinoma aggressive benign cancerous carcinomas deadly ductal exosome gtpases hypothesized immunohistochemistry implicated invasion invasive malignancies member microarray microenvironment modulating pancreatic pdac regulating represent secretion tissues tp53 trafficking vesicle
Tagcloud (Difference) ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	adenocarcinoma aggressive benign cancerous carcinomas deadly ductal exosome gtpases hypothesized immunohistochemistry implicated invasion invasive malignancies member microarray microenvironment modulating pancreatic pdac regulating represent secretion tissues tp53 trafficking vesicle
Tagcloud (Intersection) ?