MYO5A and TRIM2

Number of citations of the paper that reports this interaction (PubMedID 11432975)
0

Data Source:
HPRD (in vitro)

		MYO5A	TRIM2
Description		myosin VA	tripartite motif containing 2
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GO Annotations	Cellular Component	Ruffle Cytoplasm Lysosome Early Endosome Late Endosome Peroxisome Endoplasmic Reticulum Cytosol Actin Filament Actin Cytoskeleton Membrane Myosin Complex Growth Cone Cytoplasmic Vesicle Vesicle Filopodium Tip Insulin-responsive Compartment Melanosome Neuron Projection Recycling Endosome Extracellular Exosome	Cytoplasm
	Molecular Function	Microfilament Motor Activity Nucleotide Binding RNA Binding Cytoskeletal Motor Activity Actin Binding Catalytic Activity Protein Binding Calmodulin Binding ATP Binding ATP Hydrolysis Activity Small GTPase Binding Actin Filament Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Post-Golgi Vesicle-mediated Transport Endocytosis Actin Filament Organization Protein Transport Vesicle-mediated Transport Actin Filament-based Movement Vesicle Transport Along Actin Filament Melanosome Transport Cellular Response To Insulin Stimulus Protein Localization To Plasma Membrane Regulation Of Golgi Organization	Protein Polyubiquitination Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Apoptotic Process Cellular Response To Leukemia Inhibitory Factor
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation Insulin processing FCGR3A-mediated phagocytosis Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation	Interferon gamma signaling
Drugs
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Mean platelet volume ( 32888494) Metabolite levels (Pyroglutamine) ( 23934736)	Apolipoprotein A1 levels ( 32203549) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol ( 30275531) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Multiple sclerosis ( 21654844) Thyrotoxic periodic paralysis ( 33105104)
Interacting Genes		20 interacting genes: AKAP9 BMF CALM1 DLGAP1 DYNLL1 DYNLL2 ERG KIF5B MLPH NDEL1 NEFL PDE4B PRPH RAB11A RAB27A RAB3A RPH3A TRIM2 TRIM3 USP7	31 interacting genes: BCL2L11 CDK20 CIB3 COG3 CSNK1E DTNBP1 GJB5 KCTD7 LRRC8E MNAT1 MYO5A OTUB2 SIRPA TNFAIP3 TNIK TRIM8 UBAC1 UBE2C UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2F UBE2G1 UBE2H UBE2K UBE2N UBE2U UBE2W
Entrez ID		4644	23321
HPRD ID		01179	10279
Ensembl ID		ENSG00000197535	ENSG00000109654
Uniprot IDs		A0A8I5KTF1 A0A8J8YWI7 A8CDT9 Q9UES4 Q9Y4I1	A0A0J9YW02 A0A6Q8PF74 A0A6Q8PG16 A0A6Q8PGG4 A0A6Q8PHP4 Q9C040
PDB IDs		4D07 4J5L 4LLI 4LX1 4LX2 5JCY 5JCZ	7B2R 7B96 7QRV 7ZJ3 8A38 8AMS
Enriched GO Terms of Interacting Partners?		Establishment Of Vesicle Localization Vesicle Localization Establishment Of Organelle Localization Organelle Localization Axon Cytoplasm Myosin V Binding Establishment Of Localization In Cell Retrograde Axonal Transport Protein-containing Complex Binding Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Pigment Granule Localization Regulation Of Transport Centrosome Centrosome Localization Exosomal Secretion Synaptic Vesicle Transport Microtubule Associated Complex Synaptic Vesicle Membrane Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Microtubule-based Process Positive Regulation Of Regulated Secretory Pathway Lysosome Localization Transport Along Microtubule Vesicle Axonal Transport Neurofilament Cytoskeleton Organization Microtubule-based Movement Cytoskeleton-dependent Intracellular Transport Cytosol Microtubule-based Transport Axo-dendritic Transport Positive Regulation Of Exocytosis Cytoskeleton Organelle Transport Along Microtubule Protein Transport Vesicle-mediated Transport In Synapse Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Organelle Organization Secretory Granule Regulation Of Intracellular Transport Intracellular Transport Regulation Of Cellular Localization Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification Process Protein K11-linked Ubiquitination ATP Binding Transferase Activity Nucleotide Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Protein Monoubiquitination Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Proteolysis Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteasomal Protein Catabolic Process Ubiquitin-like Protein Transferase Activity Protein Catabolic Process ISG15 Transferase Activity Ubiquitin Ligase Complex ISG15-protein Conjugation Cellular Response To Stress DNA Damage Response Free Ubiquitin Chain Polymerization Catabolic Process Cytosol Protein K11-linked Deubiquitination Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway DNA Repair Filopodium Tip Protein Binding Ubiquitin Binding Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Protein K6-linked Ubiquitination Regulation Of Lipopolysaccharide-mediated Signaling Pathway B Cell Homeostasis DNA Metabolic Process Nucleus Tolerance Induction To Lipopolysaccharide Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Defense Response To Virus
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