MYO5A and NEFL

Number of citations: 50 (PubMedID 12403814)
Data Source: HPRD (in vivo, in vitro)

		MYO5A	NEFL
Name		myosin VA	neurofilament light chain
Structure			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Lysosome Early Endosome Late Endosome Peroxisome Endoplasmic Reticulum Cytosol Actin Filament Actin Cytoskeleton Membrane Myosin Complex Growth Cone Cytoplasmic Vesicle Vesicle Filopodium Tip Insulin-responsive Compartment Melanosome Neuron Projection Recycling Endosome Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Intermediate Filament Neurofilament Axon Growth Cone Neuromuscular Junction Cell Projection Neuron Projection Intermediate Filament Cytoskeleton Schaffer Collateral - CA1 Synapse Cholinergic Synapse Postsynaptic Intermediate Filament Cytoskeleton Presynaptic Intermediate Filament Cytoskeleton Axon Cytoplasm
	Molecular Function	Microfilament Motor Activity Nucleotide Binding RNA Binding Cytoskeletal Motor Activity Actin Binding Catalytic Activity Protein Binding Calmodulin Binding ATP Binding ATP Hydrolysis Activity Small GTPase Binding Actin Filament Binding	Structural Constituent Of Cytoskeleton Protein Binding Tubulin Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Phospholipase Binding Protein-containing Complex Binding Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
	Biological Process	Post-Golgi Vesicle-mediated Transport Endocytosis Actin Filament Organization Protein Transport Vesicle-mediated Transport Actin Filament-based Movement Vesicle Transport Along Actin Filament Melanosome Transport Cellular Response To Insulin Stimulus Protein Localization To Plasma Membrane Regulation Of Golgi Organization	Microtubule Cytoskeleton Organization Axonogenesis Anterograde Axonal Transport Retrograde Axonal Transport Response To Toxic Substance Peripheral Nervous System Axon Regeneration Axonal Transport Of Mitochondrion Spinal Cord Development Hippocampus Development Cerebral Cortex Development Regulation Of Axon Diameter Neurofilament Bundle Assembly Locomotion Response To Peptide Hormone Intermediate Filament Polymerization Or Depolymerization Intermediate Filament Organization Intermediate Filament Bundle Assembly Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Neuromuscular Process Controlling Balance Protein Polymerization Response To Corticosterone Neurofilament Cytoskeleton Organization Regulation Of Synapse Maturation Motor Neuron Apoptotic Process Postsynaptic Modulation Of Chemical Synaptic Transmission Postsynaptic Intermediate Filament Cytoskeleton Organization Response To Sodium Arsenite Response To Acrylamide Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation Insulin processing FCGR3A-mediated phagocytosis Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Mean platelet volume ( 32888494 ) Metabolite levels (Pyroglutamine) ( 23934736 )	Fear of minor pain ( 28701861 ) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482 ) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482 )
Interacting Genes		20 interacting genes: AKAP9 BMF CALM1 DLGAP1 DYNLL1 DYNLL2 ERG KIF5B MLPH NDEL1 NEFL PDE4B PRPH RAB11A RAB27A RAB3A RPH3A TRIM2 TRIM3 USP7	55 interacting genes: BRD7 CCDC13 CCDC172 CCDC33 CCNC CDK5RAP2 CEP57L1 CHD3 DES DSCAM ENKD1 FXR1 GFAP GOLGA2 GORASP1 GRIN1 HGS ITSN1 KDM1A KIFC3 KLC3 KRT13 KRT15 KRT18 MAP2 MTMR2 MTUS2 MYO15B MYO5A NDN NEFH NEIL3 NEK6 NME7 PDE4DIP PIAS4 PKN1 PPP1R16B PPP1R18 PRMT6 RBM11 SHANK3 SKIL SMYD1 SPTAN1 TERF1 TEX11 TRIM55 TRIM63 TSC1 TXLNB USHBP1 USP2 VIM YWHAG
Entrez ID		4644	4747
HPRD ID		01179	01206
Ensembl ID		ENSG00000197535	ENSG00000277586
Uniprot IDs		A0A8I5KTF1 A0A8J8YWI7 A8CDT9 Q9UES4 Q9Y4I1	P07196
PDB IDs		4D07 4J5L 4LLI 4LX1 4LX2 5JCY 5JCZ	Not available
GO Terms Enriched among Interactors		Establishment Of Vesicle Localization Vesicle Localization Establishment Of Organelle Localization Organelle Localization Axon Cytoplasm Myosin V Binding Establishment Of Localization In Cell Retrograde Axonal Transport Protein-containing Complex Binding Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Pigment Granule Localization Regulation Of Transport Centrosome Centrosome Localization Exosomal Secretion Synaptic Vesicle Transport Microtubule Associated Complex Synaptic Vesicle Membrane Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Microtubule-based Process Positive Regulation Of Regulated Secretory Pathway Lysosome Localization Transport Along Microtubule Vesicle Axonal Transport Neurofilament Cytoskeleton Organization Microtubule-based Movement Cytoskeleton-dependent Intracellular Transport Cytosol Microtubule-based Transport Axo-dendritic Transport Positive Regulation Of Exocytosis Cytoskeleton Organelle Transport Along Microtubule Protein Transport Vesicle-mediated Transport In Synapse Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Organelle Organization Secretory Granule Regulation Of Intracellular Transport Intracellular Transport Regulation Of Cellular Localization Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane	Cytoskeleton Microtubule Microtubule Binding Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Cytoplasm Intermediate Filament Organization Organelle Organization Centrosome Structural Constituent Of Cytoskeleton Intermediate Filament Cell Projection Microtubule-based Process Regulation Of Nervous System Development Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Neuron Projection Centrosome Cycle Intermediate Filament Cytoskeleton Regulation Of Neurogenesis Supramolecular Fiber Organization Regulation Of Developmental Process Regulation Of Microtubule Polymerization Regulation Of Neuron Projection Development Negative Regulation Of Cellular Component Organization Positive Regulation Of Neurogenesis Plasma Membrane Bounded Cell Projection Organization Scaffold Protein Binding Dendritic Spine Cell Projection Organization Microtubule Organizing Center Organization Gamma-tubulin Binding Protein Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Nervous System Development Regulation Of Cell Development Regulation Of Cell Projection Organization Microtubule Organizing Center Regulation Of Cell Differentiation Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Organelle Organization Regulation Of Organelle Transport Along Microtubule Kinesin Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Protein-containing Complex Assembly Organelle Assembly Calmodulin Binding