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DYNLL1 and PKIA
Number of citations of the paper that reports this interaction (PubMedID
11978406
)
0
Data Source:
HPRD
(in vivo, two hybrid)
DYNLL1
PKIA
Description
dynein light chain LC8-type 1
cAMP-dependent protein kinase inhibitor alpha
Image
GO Annotations
Cellular Component
Kinetochore
Nucleus
Chromosome
Cytoplasm
Mitochondrion
Centrosome
Cytosol
Cytoskeleton
Cytoplasmic Dynein Complex
Microtubule
Microtubule Associated Complex
Plasma Membrane
Cilium
COP9 Signalosome
Microtubule Cytoskeleton
Membrane
Secretory Granule
Dynein Complex
Site Of Double-strand Break
Tertiary Granule Membrane
Mitotic Spindle
Ciliary Tip
Ficolin-1-rich Granule Membrane
Axon Cytoplasm
Nucleus
Cytoplasm
Molecular Function
Enzyme Inhibitor Activity
Protein Binding
Enzyme Binding
Nitric-oxide Synthase Regulator Activity
Nitric-oxide Synthase Inhibitor Activity
Identical Protein Binding
Protein-containing Complex Binding
Dynein Intermediate Chain Binding
Deoxyribonuclease Inhibitor Activity
Scaffold Protein Binding
Protein Kinase Inhibitor Activity
CAMP-dependent Protein Kinase Inhibitor Activity
Protein Binding
Protein Kinase A Catalytic Subunit Binding
Biological Process
Apoptotic Process
DNA Damage Response
Microtubule-based Process
Spermatid Development
Substantia Nigra Development
Positive Regulation Of Intracellular Transport
Intraciliary Retrograde Transport
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Negative Regulation Of Phosphorylation
Motile Cilium Assembly
Negative Regulation Of Nitric Oxide Biosynthetic Process
DNA Strand Resection Involved In Replication Fork Processing
Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of CAMP/PKA Signal Transduction
Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways
Activation of BIM and translocation to mitochondria
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Macroautophagy
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
Intraflagellar transport
RHO GTPases Activate Formins
Neutrophil degranulation
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
AURKA Activation by TPX2
HCMV Early Events
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Drugs
3,5-Diiodotyrosine
Hydroxyfasudil
(2S)-1-(3H-Indol-3-yl)-3-{[5-(6-isoquinolinyl)-3-pyridinyl]oxy}-2-propanamine
(1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE
(1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE
(4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE
N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
(S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE
(2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine
(2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
(2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE
(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
H-89
5-(2-methylpiperazine-1-sulfonyl)isoquinoline
N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE
2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
3-pyridin-4-yl-1H-indazole
5-benzyl-1,3-thiazol-2-amine
1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium
Fasudil
Myristic acid
A-674563
3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE
Y-27632
Diseases
GWAS
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
27863252
32888494
)
Immature fraction of reticulocytes (
27863252
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Reading disability or specific language impairment (pleiotropy) (
25065397
)
Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) (
25065397
)
Reticulocyte count (
27863252
32888494
)
Reticulocyte fraction of red cells (
27863252
32888494
)
Femoral neck bone mineral density (
22504420
)
Intraocular pressure (
29617998
31959993
)
Multiple sclerosis (
21833088
)
Optic disc size (
31809533
)
Systemic lupus erythematosus (
28714469
)
Systolic blood pressure response to hydrochlorothiazide in hypertension (
27802415
)
Interacting Genes
108 interacting genes:
ACTB
ACTC1
ACTG1
ALDOA
AMOTL2
B3GALT4
BACH1
BCAS1
BCL2L11
BMF
C14orf119
C19orf44
CA2
CACNB1
CCDC28A
CIMAP1A
CLIP2
COXFA4L2
CS
DAZ1
DCTN5
DLG4
DLGAP1
DNAJB9
DNM2
DNM3
DNMT1
DPPA3
DYNC1H1
DYNC1I1
DYRK1A
EEF1A1
ERG28
FAM153A
FAM53B
GABARAPL1
GABARAPL2
GAPDH
GLUD1
GLUL
GNL3L
GPHN
GPRIN2
GRIN3A
HIP1R
HMBOX1
HOMER3
HSPA8
IHO1
INPP1
IQUB
KANK2
LDHA
MAP1B
MARK3
MAST2
ME2
MORC3
MORN3
MRE11
MTA1
MTR
MYO10
MYO5A
NDEL1
NFKBIA
NOS1
NRF1
NTRK1
NTRK2
NTRK3
OR7C2
OTUD6A
PAK1
PAN2
PARD3
PAX6
PCM1
PFKM
PFKP
PKIA
PKIB
PKIG
POLH
PPP3R2
RAB4A
RACK1
RASGRP4
REDIC1
RGS2
SHROOM3
SLC13A1
SMCP
TERT
THAP10
THAP8
TNFRSF14
TP53BP1
TRIM54
TSNARE1
TUBA3C
TUBB
TXNDC17
VIM
ZHX1
ZMYND11
ZNF354A
ZNF710
12 interacting genes:
AGFG1
CASP6
DYNLL1
DYNLL2
EGFR
JUNB
MRNIP
PRC1
PRKACA
PRKACB
PRKX
XPO1
Entrez ID
8655
5569
HPRD ID
03334
05828
Ensembl ID
ENSG00000088986
ENSG00000171033
Uniprot IDs
P63167
Q6FGH9
P61925
PDB IDs
1CMI
3ZKE
3ZKF
6GZJ
6GZL
6RLB
6SC2
7D35
8PR0
8PR1
8PTK
8RGG
1CMK
1JLU
1Q8T
1VEB
1XH4
1XH5
1XH6
1XH7
1XH8
1XH9
1XHA
1YDR
2C1A
2C1B
2F7E
2GNI
2JDS
2JDT
2JDV
2L1L
2UVX
2UVY
2UVZ
2UW0
2UW3
2UW4
2UW5
2UW6
2UW7
2UW8
2VNW
2VNY
2VO0
2VO3
2VO6
2VO7
3AMA
3AMB
3L9L
3L9M
3L9N
3MVJ
3NX8
3OOG
3OVV
3OWP
3OXT
3P0M
3POO
3VQH
3WYG
3X2U
3X2V
3X2W
4AXA
4IAC
4IAD
4IAF
4IAI
4IAK
4IAY
4IAZ
4IB0
4IB1
4IB3
4IE9
4IJ9
4O21
4O22
4UJ1
4UJ2
4UJ9
4UJA
4UJB
4WB5
4WB6
4WB7
4WB8
4Z83
4Z84
5BX6
5BX7
5DH9
5LCP
5LCQ
5LCR
5LCT
5LCU
5M0B
5M0C
5M0L
5M0U
5M6V
5M6Y
5M71
5M75
5N23
5XOJ
6E21
6E99
6E9L
6FRX
6QJ7
6X2U
6X2V
6X2W
7UJX
7V0G
8FE2
8FE5
8FEC
Enriched GO Terms of Interacting Partners
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Cytoskeleton
Microtubule
Cytoplasm
Postsynaptic Density
Microtubule Binding
Neurotrophin Receptor Activity
Neurotrophin Binding
Cytosol
Pyruvate Metabolic Process
Neuron Projection Morphogenesis
Nucleotide Binding
Cell Projection Morphogenesis
Glycolytic Process
Fructose 1,6-bisphosphate Metabolic Process
Cytoskeleton Organization
Actin Filament
Identical Protein Binding
ADP Catabolic Process
Purine Ribonucleoside Diphosphate Catabolic Process
Microtubule-based Process
Apical Junction Complex
ADP Metabolic Process
Nucleoside Diphosphate Catabolic Process
Ribonucleoside Diphosphate Catabolic Process
Positive Regulation Of Cellular Component Biogenesis
Replication Fork
CAMP-dependent Protein Kinase Inhibitor Activity
Cytoskeleton-dependent Intracellular Transport
Dendritic Spine
Organelle Organization
Axon
Establishment Of Organelle Localization
Axonogenesis
Microtubule Associated Complex
Carbohydrate Catabolic Process
Peptidyl-cysteine S-nitrosylase Activity
6-phosphofructokinase Activity
6-phosphofructokinase Complex
Beta-tubulin Binding
Ribonucleoside Diphosphate Metabolic Process
Purine Ribonucleotide Catabolic Process
Microtubule Cytoskeleton Organization
Substantia Nigra Development
Negative Regulation Of Protein Import Into Nucleus
Myelination In Peripheral Nervous System
Regulation Of Transport
Nucleoside Diphosphate Metabolic Process
Regulation Of Transepithelial Transport
Calyx Of Held
Fructose-6-phosphate Binding
CAMP-dependent Protein Kinase Activity
CAMP-dependent Protein Kinase Complex
Nucleus
High-density Lipoprotein Particle Assembly
Vascular Endothelial Cell Response To Laminar Fluid Shear Stress
Regulation Of Cell Cycle
Vascular Endothelial Cell Response To Fluid Shear Stress
Cellular Response To Laminar Fluid Shear Stress
Renal Water Homeostasis
Nuclear Export
Response To Laminar Fluid Shear Stress
Plasma Lipoprotein Particle Assembly
Cytoplasmic Dynein Complex
Protein-lipid Complex Assembly
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Multicellular Organismal-level Water Homeostasis
Cytosol
Protein Kinase Activity
Cellular Response To Fluid Shear Stress
Regulation Of Protein Export From Nucleus
Protein Export From Nucleus
Negative Regulation Of Smoothened Signaling Pathway
Dynein Intermediate Chain Binding
Dynein Complex
Microtubule Associated Complex
Regulation Of Cellular Localization
Ciliary Base
Peptidyl-serine Phosphorylation
Response To Fluid Shear Stress
Regulation Of Phosphorus Metabolic Process
Cilium
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Ciliary Tip
Intracellular Signal Transduction
Kinase Activity
Multivesicular Body, Internal Vesicle Lumen
Nuclear Transport
Nucleocytoplasmic Transport
Microtubule Cytoskeleton
Myosin V Complex
Regulation Of Protein Processing
Regulation Of Intracellular Transport
Centrosome
Regulation Of Protein Maturation
TORC1 Signaling
Negative Regulation Of TORC1 Signaling
MRNA Export From Nucleus
Ubiquitin Protein Ligase Binding
Multicellular Organismal-level Chemical Homeostasis
Scaffold Protein Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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