DYNLL1 and BCL2L11

Number of citations of the paper that reports this interaction (PMID 12591950)
194

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		DYNLL1	BCL2L11
Gene Name		dynein, light chain, LC8-type 1	BCL2-like 11 (apoptosis facilitator)
Image
Gene Ontology Annotations	Cellular Component	Kinetochore Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane COP9 Signalosome Membrane Extracellular Vesicular Exosome Primary Cilium Mitotic Spindle Ciliary Tip	Mitochondrial Outer Membrane Cytosol Microtubule Endomembrane System Extrinsic Component Of Membrane BIM-BCL-xl Complex BIM-BCL-2 Complex
	Molecular Function	Motor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Nitric-oxide Synthase Regulator Activity Protein Homodimerization Activity	Protein Binding Microtubule Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transport Apoptotic Process Organelle Organization Microtubule-based Process Female Gamete Generation Anatomical Structure Morphogenesis Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Substantia Nigra Development Actin Cytoskeleton Organization Negative Regulation Of Phosphorylation Regulation Of Catalytic Activity Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	In Utero Embryonic Development B Cell Homeostasis B Cell Apoptotic Process Kidney Development Myeloid Cell Homeostasis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell-matrix Adhesion Spermatogenesis Brain Development Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mammary Gland Development Positive Regulation Of Protein Homooligomerization Response To Endoplasmic Reticulum Stress Tube Formation Odontogenesis Of Dentin-containing Tooth T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ear Development Positive Regulation Of Cell Cycle Regulation Of Organ Growth Neurotrophin TRK Receptor Signaling Pathway Developmental Pigmentation Regulation Of Developmental Pigmentation Spleen Development Thymus Development Post-embryonic Organ Morphogenesis Positive Regulation Of Apoptotic Process By Virus Cellular Process Regulating Host Cell Cycle In Response To Virus Thymocyte Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Organelle biogenesis and maintenance Activation of BH3-only proteins Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Intraflagellar transport Loss of proteins required for interphase microtubule organizationÂ from the centrosome Activation of BIM and translocation to mitochondria Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Programmed Cell Death Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System Intrinsic Pathway for Apoptosis	Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Activation of BIM and translocation to mitochondria NRAGE signals death through JNK Programmed Cell Death Activation of BH3-only proteins p75 NTR receptor-mediated signalling BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS			Chronic lymphocytic leukemia ( 18758461) Dehydroepiandrosterone sulphate levels ( 21533175) Primary sclerosing cholangitis ( 21151127)
Protein-Protein Interactions		77 interactors: ACTB ACTC1 ACTG1 ALDOA AMBRA1 AMOTL2 B3GALT4 BCAS1 BCL2L11 BMF C14orf1 CA2 CACNB1 CCDC36 CLIP2 CS DAZ1 DLG4 DLGAP1 DNAJB9 DNM2 DNM3 DNMT1 DYNC1H1 DYNC1I1 EEF1A1 GAPDH GLUD1 GLUL GNB2L1 GPHN GRIN3A HIP1R HSPA8 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MTA1 MTR MYO10 MYO5A NDUFA4L2 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 PAK1 PAN2 PARD3 PAX6 PFKM PFKP PKIA PKIB PKIG POLH RAB4A RGS2 SHROOM3 TERT THAP8 TNFRSF14 TP53BP1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A	26 interactors: AKT1 APP ATP6V1G1 AURKB BCL2 BCL2A1 BCL2L1 BCL2L2 BTK DYNLL1 DYNLL2 FEM1C FGL1 GNB2L1 GTF2I MAGEA11 MAPK10 MAPK8 MAPK9 MCL1 MEX3D RIOK3 SMARCB1 TRIM2 VDAC1 YWHAB
Entrez ID		8655	10018
HPRD ID		03334	04828
Ensembl ID		ENSG00000088986	ENSG00000153094
Uniprot IDs		P63167 Q6FGH9	O43521
PDB IDs		1CMI 3ZKE 3ZKF	1F95 2K7W 2NL9 2V6Q 2VM6 2WH6 2YQ6 3D7V 3FDL 3IO8 3IO9 3KJ0 3KJ1 3KJ2 4B4S
Enriched GO Terms of Interacting Partners?		Nervous System Development Movement Of Cell Or Subcellular Component Cell Differentiation Developmental Process Regulation Of Cellular Component Organization Response To Organic Substance Regulation Of Cellular Localization Neuron Projection Morphogenesis Axonogenesis Cellular Response To Stimulus Synapse Organization Neuron Projection Development Neuron Development Regulation Of Cellular Protein Metabolic Process Response To Stimulus Neuron Differentiation Regulation Of Protein Metabolic Process Axon Development Cell Projection Morphogenesis Response To External Stimulus Anatomical Structure Morphogenesis Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Cell Part Morphogenesis Cellular Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Protein Homooligomerization Cell Morphogenesis Axon Guidance Negative Regulation Of Phosphorylation Regulation Of Cellular Process Glycolytic Process Locomotion Cell Development Negative Regulation Of Protein Phosphorylation Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Membrane Organization Regulation Of CAMP-dependent Protein Kinase Activity Cell Morphogenesis Involved In Differentiation Anatomical Structure Development Generation Of Neurons System Development Response To Stress Regulation Of Protein Phosphorylation Multicellular Organismal Development Neuromuscular Junction Development Pyruvate Metabolic Process Actin Filament-based Process	Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Programmed Cell Death Cell Death Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand JUN Phosphorylation Intracellular Signal Transduction Apoptotic Mitochondrial Changes Regulation Of Signal Transduction Response To Radiation Positive Regulation Of Signal Transduction Response To Light Stimulus Regulation Of Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Stress Positive Regulation Of Intracellular Transport Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Response To UV Regulation Of Establishment Of Protein Localization Fc Receptor Signaling Pathway Negative Regulation Of Cell Death Immune Response-regulating Signaling Pathway Regulation Of Neuron Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Defense Response Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Anoikis
Tagcloud ?		1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating	akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Difference) ?		1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating	akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Intersection) ?